ID   RBGA_BACP2              Reviewed;         282 AA.
AC   A8FD69;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Ribosome biogenesis GTPase A {ECO:0000250|UniProtKB:O31743};
GN   Name=rbgA {ECO:0000250|UniProtKB:O31743};
GN   Synonyms=ylqF {ECO:0000312|EMBL:ABV62186.1}; OrderedLocusNames=BPUM_1503;
OS   Bacillus pumilus (strain SAFR-032).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=315750;
RN   [1] {ECO:0000312|EMBL:ABV62186.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAFR-032 {ECO:0000312|EMBL:ABV62186.1};
RX   PubMed=17895969; DOI=10.1371/journal.pone.0000928;
RA   Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D.,
RA   Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H.,
RA   Lee S., Nazareth L., Blyth P., Holder M., Buhay C., Tirumalai M.R., Liu Y.,
RA   Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P.,
RA   Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D.,
RA   Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F.,
RA   Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K.,
RA   Weinstock G.M.;
RT   "Paradoxical DNA repair and peroxide resistance gene conservation in
RT   Bacillus pumilus SAFR-032.";
RL   PLoS ONE 2:E928-E928(2007).
CC   -!- FUNCTION: Essential protein that is required for a late step of 50S
CC       ribosomal subunit assembly. Has GTPase activity that is stimulated by
CC       interaction with the immature 50S ribosome subunit. Binds to the 23S
CC       rRNA. Required for the association of ribosomal proteins rplP and rpmA
CC       with the large subunit (By similarity). {ECO:0000250|UniProtKB:O31743}.
CC   -!- SUBUNIT: Interacts with ctc. Interacts with the immature 50S ribosome
CC       subunit. 2 molecules of rbgA bind to one 50S subunit (By similarity).
CC       {ECO:0000250|UniProtKB:O31743}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O31743,
CC       ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR   EMBL; CP000813; ABV62186.1; -; Genomic_DNA.
DR   RefSeq; WP_012009941.1; NC_009848.4.
DR   AlphaFoldDB; A8FD69; -.
DR   SMR; A8FD69; -.
DR   STRING; 315750.BPUM_1503; -.
DR   EnsemblBacteria; ABV62186; ABV62186; BPUM_1503.
DR   KEGG; bpu:BPUM_1503; -.
DR   eggNOG; COG1161; Bacteria.
DR   HOGENOM; CLU_011106_1_0_9; -.
DR   OMA; GVLWPKF; -.
DR   OrthoDB; 1083771at2; -.
DR   Proteomes; UP000001355; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1580.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030378; G_CP_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR   InterPro; IPR019991; GTP-bd_ribosome_bgen.
DR   InterPro; IPR016478; GTPase_MTG1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   PIRSF; PIRSF006230; MG442; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03596; GTPase_YlqF; 1.
DR   PROSITE; PS51721; G_CP; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome;
KW   Ribosome biogenesis; RNA-binding.
FT   CHAIN           1..282
FT                   /note="Ribosome biogenesis GTPase A"
FT                   /id="PRO_0000409883"
FT   DOMAIN          14..178
FT                   /note="CP-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT   BINDING         58..61
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:O31743"
FT   BINDING         86..87
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:O31743"
FT   BINDING         130..135
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:O31743"
FT   BINDING         174
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:O31743"
SQ   SEQUENCE   282 AA;  32019 MW;  6926B00F9B673C0B CRC64;
     MTIQWFPGHM AKARREVTEK LKLIDIVFEL TDARIPMSSR NPMIEEILQN KPKIMLLNKA
     DKADPRVTKE WQAHFEQQGV RSLAINSVDG QGLNQIITTS KEILKEKFDR MKAKGVKPRA
     IRALIIGIPN VGKSTLINRL AKKNIAKTGD RPGITTSQQW VKVGKEMELL DTPGILWPKF
     EDEKVGLRLA VTGAIKDSII NLQDVAVYGL RFLEENYPER LKKRYDLTDI PEDTAELFDA
     IGTKRGCLMS GGFINYDKTT EIIIRDIRTE KFGPLTFEKP ES