RBGA_MYCGE
ID RBGA_MYCGE Reviewed; 270 AA.
AC Q49435;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Probable ribosome biogenesis GTPase A;
GN Name=rbgA; OrderedLocusNames=MG442;
OS Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS (Mycoplasmoides genitalium).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=243273;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
CC -!- FUNCTION: Required for a late step of 50S ribosomal subunit assembly.
CC Has GTPase activity. Binds to the 23S rRNA (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR EMBL; L43967; AAC72462.1; -; Genomic_DNA.
DR PIR; H64248; H64248.
DR AlphaFoldDB; Q49435; -.
DR SMR; Q49435; -.
DR STRING; 243273.MG_442; -.
DR EnsemblBacteria; AAC72462; AAC72462; MG_442.
DR KEGG; mge:MG_442; -.
DR eggNOG; COG1161; Bacteria.
DR HOGENOM; CLU_011106_1_0_14; -.
DR OMA; GVLWPKF; -.
DR Proteomes; UP000000807; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR Gene3D; 1.10.1580.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR InterPro; IPR019991; GTP-bd_ribosome_bgen.
DR InterPro; IPR016478; GTPase_MTG1.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PIRSF; PIRSF006230; MG442; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03596; GTPase_YlqF; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 3: Inferred from homology;
KW Cytoplasm; GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome;
KW Ribosome biogenesis.
FT CHAIN 1..270
FT /note="Probable ribosome biogenesis GTPase A"
FT /id="PRO_0000210614"
FT DOMAIN 20..174
FT /note="CP-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT BINDING 126..131
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 170
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 270 AA; 30897 MW; 16B9072A2E83763E CRC64;
MDTYTSAKIN WFPGHMKKIH DQLKKLSSQI DGIIEIVDAR APTLTHNSEI ISYFLNKPKL
ILALKTDLAQ YKPNKKILFG SLKEPFKLKK KVLKTLTTLF ANKRQQLKAK GLLIKQFRLA
VIGMPNVGKS SLINLLINKN HLKVANRAGI TKSLNWIQIS PELLLSDTPG VFLKRIDEIQ
IGYKLVLTNV IRREVVNIEE VGMFAFNYLK KHYKQLLPFE ADSFINFLEK FAKVRGLIKK
ANELNTNLAC EIFINELING KYGKLSYELN
