RBGA_THEMA
ID RBGA_THEMA Reviewed; 262 AA.
AC Q9WZM6;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Ribosome biogenesis GTPase A {ECO:0000250|UniProtKB:O31743};
GN Name=rbgA {ECO:0000250|UniProtKB:O31743};
GN Synonyms=ylqF {ECO:0000303|PubMed:18536017}; OrderedLocusNames=TM_0768;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1] {ECO:0000312|EMBL:AAD35850.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
RN [2] {ECO:0000305, ECO:0000312|PDB:3CNN}
RP X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEXES WITH GTP; GDP AND GTP
RP ANALOG.
RX PubMed=18536017; DOI=10.1002/prot.22112;
RA Kim D.J., Jang J.Y., Yoon H.J., Suh S.W.;
RT "Crystal structure of YlqF, a circularly permuted GTPase: implications for
RT its GTPase activation in 50 S ribosomal subunit assembly.";
RL Proteins 72:1363-1370(2008).
CC -!- FUNCTION: Required for a late step of 50S ribosomal subunit assembly.
CC Has GTPase activity. Binds to the 23S rRNA (By similarity).
CC {ECO:0000250|UniProtKB:O31743}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O31743,
CC ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR EMBL; AE000512; AAD35850.1; -; Genomic_DNA.
DR PIR; F72336; F72336.
DR RefSeq; NP_228577.1; NC_000853.1.
DR RefSeq; WP_004080928.1; NZ_CP011107.1.
DR PDB; 3CNL; X-ray; 2.00 A; A=1-262.
DR PDB; 3CNN; X-ray; 2.30 A; A=1-262.
DR PDB; 3CNO; X-ray; 2.30 A; A=1-262.
DR PDBsum; 3CNL; -.
DR PDBsum; 3CNN; -.
DR PDBsum; 3CNO; -.
DR AlphaFoldDB; Q9WZM6; -.
DR SMR; Q9WZM6; -.
DR STRING; 243274.THEMA_00810; -.
DR DNASU; 898436; -.
DR EnsemblBacteria; AAD35850; AAD35850; TM_0768.
DR KEGG; tma:TM0768; -.
DR eggNOG; COG1161; Bacteria.
DR InParanoid; Q9WZM6; -.
DR OMA; GVLWPKF; -.
DR OrthoDB; 1083771at2; -.
DR EvolutionaryTrace; Q9WZM6; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR Gene3D; 1.10.1580.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR InterPro; IPR019991; GTP-bd_ribosome_bgen.
DR InterPro; IPR016478; GTPase_MTG1.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PIRSF; PIRSF006230; MG442; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03596; GTPase_YlqF; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; GTP-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..262
FT /note="Ribosome biogenesis GTPase A"
FT /id="PRO_0000409886"
FT DOMAIN 12..157
FT /note="CP-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT BINDING 54..57
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000269|PubMed:18536017"
FT BINDING 109..114
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000269|PubMed:18536017"
FT BINDING 153
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000269|PubMed:18536017"
FT HELIX 13..19
FT /evidence="ECO:0007829|PDB:3CNL"
FT STRAND 23..30
FT /evidence="ECO:0007829|PDB:3CNL"
FT TURN 34..37
FT /evidence="ECO:0007829|PDB:3CNL"
FT STRAND 47..54
FT /evidence="ECO:0007829|PDB:3CNL"
FT HELIX 56..58
FT /evidence="ECO:0007829|PDB:3CNL"
FT HELIX 61..73
FT /evidence="ECO:0007829|PDB:3CNL"
FT STRAND 78..80
FT /evidence="ECO:0007829|PDB:3CNL"
FT HELIX 87..94
FT /evidence="ECO:0007829|PDB:3CNL"
FT STRAND 101..107
FT /evidence="ECO:0007829|PDB:3CNL"
FT HELIX 112..120
FT /evidence="ECO:0007829|PDB:3CNL"
FT STRAND 139..141
FT /evidence="ECO:0007829|PDB:3CNL"
FT STRAND 147..151
FT /evidence="ECO:0007829|PDB:3CNL"
FT HELIX 162..170
FT /evidence="ECO:0007829|PDB:3CNL"
FT HELIX 176..178
FT /evidence="ECO:0007829|PDB:3CNL"
FT HELIX 182..196
FT /evidence="ECO:0007829|PDB:3CNL"
FT HELIX 202..212
FT /evidence="ECO:0007829|PDB:3CNL"
FT HELIX 218..220
FT /evidence="ECO:0007829|PDB:3CNL"
FT HELIX 224..236
FT /evidence="ECO:0007829|PDB:3CNL"
FT TURN 237..240
FT /evidence="ECO:0007829|PDB:3CNL"
SQ SEQUENCE 262 AA; 29593 MW; 9179E24C57C30CD4 CRC64;
MSWYPGHIEK AKRQIKDLLR LVNTVVEVRD ARAPFATSAY GVDFSRKETI ILLNKVDIAD
EKTTKKWVEF FKKQGKRVIT THKGEPRKVL LKKLSFDRLA RVLIVGVPNT GKSTIINKLK
GKRASSVGAQ PGITKGIQWF SLENGVKILD TPGILYKNIF SEDLAAKLLL VGSLPVERIE
DQRIFERAFE IFARSIGIES SFSEFFEDFA RKRGLLKKGG VPDIERALML FFTEVAQGKA
GRVSFERPED ITPVQQEQTR GV
