位置:首页 > 蛋白库 > RBGP1_PONAB
RBGP1_PONAB
ID   RBGP1_PONAB             Reviewed;        1069 AA.
AC   Q5RAN1;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Rab GTPase-activating protein 1;
DE   AltName: Full=GAP and centrosome-associated protein;
DE   AltName: Full=Rab6 GTPase-activating protein GAPCenA;
GN   Name=RABGAP1 {ECO:0000250|UniProtKB:Q9Y3P9};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1] {ECO:0000312|EMBL:CAH91179.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex {ECO:0000312|EMBL:CAH91179.1};
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a GTPase-activating protein of RAB6A. May play a
CC       role in microtubule nucleation by centrosome. May participate in a
CC       RAB6A-mediated pathway involved in the metaphase-anaphase transition
CC       (By similarity). {ECO:0000250|UniProtKB:Q9Y3P9}.
CC   -!- SUBUNIT: Interacts with RAB6A and tubulin gamma.
CC       {ECO:0000250|UniProtKB:Q9Y3P9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9Y3P9}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y3P9}.
CC       Note=Predominantly cytosolic but also associated with the centrosome.
CC       {ECO:0000250|UniProtKB:Q9Y3P9}.
CC   -!- DOMAIN: The arginine and glutamine fingers are critical for the GTPase-
CC       activating mechanism, they pull out Rab's 'switch 2' glutamine and
CC       insert in Rab's active site. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR858984; CAH91179.1; -; mRNA.
DR   RefSeq; NP_001125691.1; NM_001132219.1.
DR   AlphaFoldDB; Q5RAN1; -.
DR   SMR; Q5RAN1; -.
DR   STRING; 9601.ENSPPYP00000021947; -.
DR   Ensembl; ENSPPYT00000022851; ENSPPYP00000021947; ENSPPYG00000019586.
DR   GeneID; 100172613; -.
DR   KEGG; pon:100172613; -.
DR   CTD; 23637; -.
DR   eggNOG; KOG1102; Eukaryota.
DR   GeneTree; ENSGT00940000157216; -.
DR   InParanoid; Q5RAN1; -.
DR   OrthoDB; 191811at2759; -.
DR   Proteomes; UP000001595; Chromosome 9.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:InterPro.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR022164; Kinesin-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   InterPro; IPR033185; RabGAP1.
DR   PANTHER; PTHR22957:SF439; PTHR22957:SF439; 1.
DR   Pfam; PF12473; DUF3694; 1.
DR   Pfam; PF00640; PID; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00462; PTB; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS01179; PID; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Coiled coil; Cytoplasm; Cytoskeleton; GTPase activation;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..1069
FT                   /note="Rab GTPase-activating protein 1"
FT                   /id="PRO_0000298781"
FT   DOMAIN          142..298
FT                   /note="PID"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00148"
FT   DOMAIN          566..752
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          482..527
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          798..1047
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        9..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        491..508
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            608
FT                   /note="Arginine finger"
FT                   /evidence="ECO:0000250"
FT   SITE            649
FT                   /note="Glutamine finger"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         42
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y3P9"
FT   MOD_RES         360
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A2AWA9"
FT   MOD_RES         996
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y3P9"
SQ   SEQUENCE   1069 AA;  121709 MW;  AB6B268B1A12D230 CRC64;
     MDDKASVGKI SVSSDSVSTL NSEDFVLVSR QGDETPSTNN GSDDEKTGLK IVGNGSEQQL
     QKELADVLMD PPMDDQPGEK ELVKRSQLDG EGDGPLSNQL SASSTINPVP LVGLQKPEMS
     LPVKPGQGDS EASSPFTPVA DEDSVVFSKL TYLGCASVNA PRSEVEALRM MSILRSQCQI
     SLDVTLSVPN VSEGIVRLLD PQTNTEIANY PIYKILFCVR GHDGTPESDC FAFTESHYNA
     ELFRIHVFRC EIQEAVSRIL YSFATAFRRS AKQTPLSATA APQTPDSDIF TFSVSLEIKE
     DDGKGYFSAV PKDKDRQCFK LRQGIDKKIV IYVQQTTNKE LAIERCFGLL LSPGKDVRNS
     DMHLLDLESM GKSSDGKSYV ITGSWNPKSP HFQVVNEETP KDKVLFMTTA VDLVITEVQE
     PVRFLLETKV RVCSPNERLF WPFSKRSTTE NFFLKLKQIK QKERKNNTDT LYEVVCLESE
     SERERRKTTA SPSVRLPQSG SQSSVIPSPP EDDEEEDNDE PLLSGSGDVS KECAEKILET
     WGELLSKWHL NLNVRPKQLS SLVRNGVPEA LRGEVWQLLA GCHNNDHLVE KYRILITKES
     PQDSAITRDI NRTFPAHDYF KDTGGDGQDS LYKICKAYSV YDEEIGYCQG QSFLAAVLLL
     HMPEEQAFSV LVKIMFDYGL RELFKQNFED LHCKFYQLER LMQEYIPDLY NHFLDISLEA
     HMYASQWFLT LFTAKFPLYM VFHIIDLLLC EGISVIFNVA LGLLKTSKDD LLLTDFEGAL
     KFFRVQLPKR YRSEENAKKL MELACNMKIS QKKLKKYEKE YHTMREQQAQ QEDPIERFER
     ENRRLQEANM RLEQENDDLA HELVTSKIAL RKDLDNAEEK ADALNKELLM TKQKLIDAEE
     EKRRLEEESA QLKEMCRREL DKAESEIKKN SSIIGDYKQI CSQLSERLEK QQTANKVEIE
     KIRQKVDDCE RCREFFNKEG RVKGISSTKE VLDEDTDEEK ETLKNQLREM ELELAQTKLQ
     LVEAECKIQD LEHHLGLALN EVQAAKKTWF NRTLSSIKTA TGVQGKETC
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024