ID   RBGPR_CAEEL             Reviewed;        1307 AA.
AC   Q22670; Q7JLF2;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Rab3 GTPase-activating protein regulatory subunit;
DE   AltName: Full=Rab3 GTPase-activating protein 2;
GN   Name=rbg-2; ORFNames=T22C1.10;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Probable regulatory subunit of a GTPase activating protein
CC       that has specificity for Rab3 subfamily. Rab3 proteins are involved in
CC       regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-
CC       activating complex specifically converts active Rab3-GTP to the
CC       inactive form Rab3-GDP (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The Rab3 GTPase-activating complex is a heterodimer composed
CC       of rbg-1 and rbg-2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=Q22670-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=Q22670-2; Sequence=VSP_013314;
CC   -!- SIMILARITY: Belongs to the Rab3-GAP regulatory subunit family.
CC       {ECO:0000305}.
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DR   EMBL; Z75550; CAA99926.1; -; Genomic_DNA.
DR   EMBL; Z75550; CAE54924.1; -; Genomic_DNA.
DR   PIR; T25106; T25106.
DR   RefSeq; NP_001021631.1; NM_001026460.2. [Q22670-1]
DR   RefSeq; NP_001021632.1; NM_001026461.2. [Q22670-2]
DR   AlphaFoldDB; Q22670; -.
DR   BioGRID; 38010; 1.
DR   STRING; 6239.T22C1.10a; -.
DR   EPD; Q22670; -.
DR   PaxDb; Q22670; -.
DR   PeptideAtlas; Q22670; -.
DR   EnsemblMetazoa; T22C1.10a.1; T22C1.10a.1; WBGene00004318. [Q22670-1]
DR   EnsemblMetazoa; T22C1.10b.1; T22C1.10b.1; WBGene00004318. [Q22670-2]
DR   GeneID; 172574; -.
DR   KEGG; cel:CELE_T22C1.10; -.
DR   UCSC; T22C1.10b; c. elegans. [Q22670-1]
DR   CTD; 172574; -.
DR   WormBase; T22C1.10a; CE06498; WBGene00004318; rbg-2. [Q22670-1]
DR   WormBase; T22C1.10b; CE36203; WBGene00004318; rbg-2. [Q22670-2]
DR   eggNOG; KOG2727; Eukaryota.
DR   GeneTree; ENSGT00390000005794; -.
DR   HOGENOM; CLU_005666_0_0_1; -.
DR   InParanoid; Q22670; -.
DR   OMA; ERIYMAP; -.
DR   OrthoDB; 790713at2759; -.
DR   PhylomeDB; Q22670; -.
DR   Reactome; R-CEL-6811436; COPI-independent Golgi-to-ER retrograde traffic.
DR   Reactome; R-CEL-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   PRO; PR:Q22670; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00004318; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030234; F:enzyme regulator activity; ISS:UniProtKB.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.
DR   InterPro; IPR026059; Rab3GAP2.
DR   InterPro; IPR029257; RAB3GAP2_C.
DR   InterPro; IPR032839; RAB3GAP_N.
DR   PANTHER; PTHR12472; PTHR12472; 1.
DR   Pfam; PF14656; RAB3GAP2_C; 1.
DR   Pfam; PF14655; RAB3GAP2_N; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..1307
FT                   /note="Rab3 GTPase-activating protein regulatory subunit"
FT                   /id="PRO_0000191665"
FT   VAR_SEQ         1..34
FT                   /note="MSVTPVILEAYCAVSDEVAKQVKKYLLGDFAEES -> MRLPSRLKSICSEI
FT                   SQKT (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_013314"
SQ   SEQUENCE   1307 AA;  149909 MW;  7DD30FE5066347BE CRC64;
     MSVTPVILEA YCAVSDEVAK QVKKYLLGDF AEESKFERKN SESSDGSETQ FCRATEKKEN
     VEVWDDWGDK EEGAAENSLE SDESIRNWLF RCDLKTYSDA EYLLVTWESR FVVLRKPPDE
     PVYKIVCKQY IEGDPISNEI TASSIFGLSN VRHIELLDSI IIALGTLDGH VYFFTEQGTM
     LYFDRFSIFE PVNSLQFEVV KTGQTFIVVF TKGFFMINPI SLKSVLYQAK VLIAKCEKTV
     KQISESIELQ SELLAPDIKG NIIHVIFTGL HKPSTLEQYI SASYDSFYAK VEKPSLPLYS
     TFMVTTEKEF AVFVWHDREE QDKLIDDVIK YGKSLVPSFG IRKFFGISTE PARIASHMRS
     AVHAPTRSII METRVAQNVS RSPDCQYVAV TDRMARVLVI DIASRQVVLI FKGYRDASIS
     WVSVTEDDRV AQFLTIFAPR RSLLEVWTVL GNVRVCAQHV PSSECNVVTG GENKMLCGRC
     HVHTDSNSFF IDEKGEFHRI ALPFHLALTS RSRQDQHDHL LLKQLENTKT GGEDWFQTFS
     DLKMATSRKT TFQNALHNLS TAEEAHQFIA RIRSIPTSAS LGDLPNSAEK SIGFYARTVA
     ETKPPVGEYD DKDTSNYKLD SIVERILECH MQKFGERTDM LNDSEVMKVG EWLKYVDLSQ
     EDIDVFSEHW SEKQRHCLAN LIFGPLFGSF EIDEYYDTVL EKIPVKRKNI VKLFYMRFEK
     TTTHIDWRIF NRIVEMFLNL EKSETGILEQ VDQMAMDSKD VPLGMILLSI CWCARIQIRI
     LKGNDEDEVE NDHDLEEEDE KNKTIDEWDA ISPEAEHLDC IIMCLHCVSL AQSLLKDDSN
     ILRISDVVPR IDSYIRENVA KWIVSTPIDT DTIEKLFPRD PSENLAEKGN EEDRRKQMII
     DFPDDKEVVI QRMYQIIPRV FEHDLVVADV CWEMMSQWFR EKDDNFSYIK DCTTLLPQSI
     VDPRLRHGIA RLIWDKFIFM VFQSIVNMVE KTGRRPKDKE TRKEIGFGEV KLEEFLMECE
     KFLEVLMDSV RDMPPPIDFK QDLLVEMASS SFAAHLHQSK TAYRQDQFAI LASRQPLVNF
     HLVLHHQHLA LALRLQLTTG LRFHPLRNLF CVTGNRAFFA SLDSHPLIPL DRVDDATMEK
     RHAFLVKVAE QGSMEERRLA RHLEMEWKLT VNEISFMQAL SSFRLGNDHQ GSLELASCVR
     DDRSAVALAR VLAARLIQLA NEANKRYSTA HSQYLCALAG EEAARVELYE NSPDDPLVDS
     NPKTWKDAVT SLGRAGNSVP QSAQAAIPFV RMNDIAKLYF GAQWVNN