RBIS_MOUSE
ID RBIS_MOUSE Reviewed; 97 AA.
AC Q0VG62; G3UW58;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-MAY-2019, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Ribosomal biogenesis factor {ECO:0000305};
GN Name=Rbis;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Trans-acting factor in ribosome biogenesis required for
CC efficient 40S and 60S subunit production.
CC {ECO:0000250|UniProtKB:Q8N0T1}.
CC -!- SUBUNIT: Associates with the pre-60S ribosomal particles.
CC {ECO:0000250|UniProtKB:Q8N0T1}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q8N0T1}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0VG62-2; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0VG62-1; Sequence=VSP_060139;
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DR EMBL; AC140350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466608; EDL07532.1; -; Genomic_DNA.
DR EMBL; CH466577; EDL05138.1; -; Genomic_DNA.
DR EMBL; BC115807; AAI15808.1; -; mRNA.
DR EMBL; BC100487; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS79886.1; -. [Q0VG62-2]
DR CCDS; CCDS84610.1; -. [Q0VG62-1]
DR RefSeq; NP_001093144.1; NM_001099674.1. [Q0VG62-2]
DR RefSeq; NP_001334135.1; NM_001347206.1. [Q0VG62-1]
DR AlphaFoldDB; Q0VG62; -.
DR SMR; Q0VG62; -.
DR IntAct; Q0VG62; 1.
DR MINT; Q0VG62; -.
DR STRING; 10090.ENSMUSP00000104002; -.
DR iPTMnet; Q0VG62; -.
DR PhosphoSitePlus; Q0VG62; -.
DR EPD; Q0VG62; -.
DR MaxQB; Q0VG62; -.
DR PaxDb; Q0VG62; -.
DR PRIDE; Q0VG62; -.
DR ProteomicsDB; 340892; -.
DR Antibodypedia; 59064; 39 antibodies from 9 providers.
DR Ensembl; ENSMUST00000108365; ENSMUSP00000104002; ENSMUSG00000078784. [Q0VG62-1]
DR Ensembl; ENSMUST00000185384; ENSMUSP00000139512; ENSMUSG00000078784. [Q0VG62-2]
DR GeneID; 69126; -.
DR KEGG; mmu:69126; -.
DR UCSC; uc008oql.1; mouse. [Q0VG62-2]
DR CTD; 401466; -.
DR MGI; MGI:1916376; Rbis.
DR VEuPathDB; HostDB:ENSMUSG00000078784; -.
DR eggNOG; ENOG502S982; Eukaryota.
DR GeneTree; ENSGT00390000015564; -.
DR HOGENOM; CLU_152931_0_0_1; -.
DR InParanoid; Q0VG62; -.
DR OrthoDB; 1613527at2759; -.
DR PhylomeDB; Q0VG62; -.
DR TreeFam; TF330773; -.
DR BioGRID-ORCS; 69126; 8 hits in 33 CRISPR screens.
DR ChiTaRS; Rbis; mouse.
DR PRO; PR:Q0VG62; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q0VG62; protein.
DR Bgee; ENSMUSG00000078784; Expressed in yolk sac and 225 other tissues.
DR ExpressionAtlas; Q0VG62; baseline and differential.
DR Genevisible; Q0VG62; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0042254; P:ribosome biogenesis; ISS:UniProtKB.
DR InterPro; IPR031389; RBIS.
DR PANTHER; PTHR35544; PTHR35544; 1.
DR Pfam; PF15679; DUF4665; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..97
FT /note="Ribosomal biogenesis factor"
FT /id="PRO_0000324605"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N0T1"
FT MOD_RES 21
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q8N0T1"
FT MOD_RES 69
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N0T1"
FT VAR_SEQ 1
FT /note="M -> MLAAAAPRALFCQLLVLYRFLVGDRTPGVPRPETLRPPLSRTM (in
FT isoform 2)"
FT /id="VSP_060139"
SQ SEQUENCE 97 AA; 11163 MW; 9244010D2966D6A3 CRC64;
MAKNKLKGQK SRNVFHIASH KTFKAKNKAK PVTTNLKKIN IMNHEKVNRM NRAFVNIQKE
LANFSKSLSL KSVQKELKHH ENEPANVDEA TRLMAQL
