RBL17_ARATH
ID RBL17_ARATH Reviewed; 320 AA.
AC B3H707; B6EUB0; B6EUB8; F4HTU9; F4HTV0; Q1PFD5; Q1PFD6; Q5XVF7; Q5XVF8;
AC Q9C6A3;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Rhomboid-like protein 17, chloroplastic {ECO:0000303|PubMed:16895613};
DE Short=AtRBL17 {ECO:0000303|PubMed:16895613};
DE Flags: Precursor;
GN Name=RBL17 {ECO:0000303|PubMed:16895613};
GN OrderedLocusNames=At1g74140 {ECO:0000312|Araport:AT1G74140};
GN ORFNames=F9E11.9 {ECO:0000312|EMBL:AAG51876.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000312|Proteomes:UP000006548};
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000312|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 2).
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5).
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16895613; DOI=10.1186/1471-2164-7-200;
RA Tripathi L.P., Sowdhamini R.;
RT "Cross genome comparisons of serine proteases in Arabidopsis and rice.";
RL BMC Genomics 7:200-200(2006).
RN [6]
RP GENE FAMILY.
RX PubMed=17938163; DOI=10.1101/gr.6425307;
RA Lemberg M.K., Freeman M.;
RT "Functional and evolutionary implications of enhanced genomic analysis of
RT rhomboid intramembrane proteases.";
RL Genome Res. 17:1634-1646(2007).
CC -!- FUNCTION: Probable rhomboid-type serine protease that catalyzes
CC intramembrane proteolysis. {ECO:0000303|PubMed:16895613}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane {ECO:0000255};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=B3H707-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B3H707-2; Sequence=VSP_057736;
CC Name=3;
CC IsoId=B3H707-3; Sequence=VSP_057735, VSP_057736;
CC Name=4;
CC IsoId=B3H707-4; Sequence=VSP_057735;
CC Name=5;
CC IsoId=B3H707-5; Sequence=VSP_057737;
CC -!- SIMILARITY: Belongs to the peptidase S54 family. {ECO:0000305}.
CC -!- CAUTION: Might be an inactive rhomboid-type serine protease due to
CC mismatches with the consensus active sites.
CC {ECO:0000303|PubMed:17938163}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51876.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC079678; AAG51876.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE35555.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35556.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35557.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35558.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35559.1; -; Genomic_DNA.
DR EMBL; AY735564; AAU44434.1; -; mRNA.
DR EMBL; AY735565; AAU44435.1; -; mRNA.
DR EMBL; DQ446427; ABE65770.1; -; mRNA.
DR EMBL; DQ446428; ABE65771.1; -; mRNA.
DR PIR; E96769; E96769.
DR RefSeq; NP_001031280.1; NM_001036203.1. [B3H707-3]
DR RefSeq; NP_001077819.1; NM_001084350.2. [B3H707-4]
DR RefSeq; NP_001077820.1; NM_001084351.2. [B3H707-5]
DR RefSeq; NP_001117599.1; NM_001124127.1. [B3H707-1]
DR RefSeq; NP_177554.2; NM_106074.2. [B3H707-2]
DR AlphaFoldDB; B3H707; -.
DR STRING; 3702.AT1G74140.5; -.
DR MEROPS; S54.A07; -.
DR PaxDb; B3H707; -.
DR PRIDE; B3H707; -.
DR ProteomicsDB; 236492; -. [B3H707-1]
DR EnsemblPlants; AT1G74140.1; AT1G74140.1; AT1G74140. [B3H707-2]
DR EnsemblPlants; AT1G74140.2; AT1G74140.2; AT1G74140. [B3H707-3]
DR EnsemblPlants; AT1G74140.3; AT1G74140.3; AT1G74140. [B3H707-4]
DR EnsemblPlants; AT1G74140.4; AT1G74140.4; AT1G74140. [B3H707-5]
DR EnsemblPlants; AT1G74140.5; AT1G74140.5; AT1G74140. [B3H707-1]
DR GeneID; 843754; -.
DR Gramene; AT1G74140.1; AT1G74140.1; AT1G74140. [B3H707-2]
DR Gramene; AT1G74140.2; AT1G74140.2; AT1G74140. [B3H707-3]
DR Gramene; AT1G74140.3; AT1G74140.3; AT1G74140. [B3H707-4]
DR Gramene; AT1G74140.4; AT1G74140.4; AT1G74140. [B3H707-5]
DR Gramene; AT1G74140.5; AT1G74140.5; AT1G74140. [B3H707-1]
DR KEGG; ath:AT1G74140; -.
DR Araport; AT1G74140; -.
DR TAIR; locus:2037328; AT1G74140.
DR eggNOG; KOG2980; Eukaryota.
DR InParanoid; B3H707; -.
DR OMA; NMFGPAF; -.
DR OrthoDB; 1554324at2759; -.
DR PhylomeDB; B3H707; -.
DR PRO; PR:B3H707; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; B3H707; differential.
DR Genevisible; B3H707; AT.
DR GO; GO:0031969; C:chloroplast membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR Gene3D; 1.20.1540.10; -; 1.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR Pfam; PF01694; Rhomboid; 1.
DR SUPFAM; SSF144091; SSF144091; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chloroplast; Membrane; Plastid; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..87
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 88..320
FT /note="Rhomboid-like protein 17, chloroplastic"
FT /evidence="ECO:0000255"
FT /id="PRO_0000433336"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 128..146
FT /note="Missing (in isoform 3 and isoform 4)"
FT /id="VSP_057735"
FT VAR_SEQ 273..275
FT /note="Missing (in isoform 2 and isoform 3)"
FT /id="VSP_057736"
FT VAR_SEQ 276..289
FT /note="Missing (in isoform 5)"
FT /id="VSP_057737"
FT CONFLICT 4
FT /note="I -> V (in Ref. 4; ABE65771/ABE65770 and 3;
FT AAU44435/AAU44434)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 320 AA; 34678 MW; 0C38A18309C95659 CRC64;
MHAIFSSFSR KVVVNVGASS QSQLTKMVKK KPNQSRHLLP SRLSSPSSVP HFVPSAVSRS
AKVHGFFASK LGNTNLKLKF GNVMESRAGF FSSELPSHGF ESGGFTGFQK RGWKSWINGA
NGVVFGLVIA NAAVFTMWRV SDRSWMLSTY SFTSGYIHTL ITSGFSHIGT SQIILNMIGI
SYFGSRIART LGPLYLLKLY FAGALGGSVC FLSYHALLAT LKGEGVVIKD HQSTAPISQL
LGADGSMFAI ALLDMFIYPK VTTYFALMLR VHVMFRIINL GVEILNIPEG GPNHIASSSG
QLGGVVVAAM AWARIKKGRF
