RBL18_ARATH
ID RBL18_ARATH Reviewed; 287 AA.
AC Q8RXQ2; O80671;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Rhomboid-like protein 18 {ECO:0000303|PubMed:16895613};
DE Short=AtRBL18 {ECO:0000303|PubMed:16895613};
GN Name=RBL18 {ECO:0000303|PubMed:16895613};
GN OrderedLocusNames=At2g41160 {ECO:0000312|Araport:AT2G41160};
GN ORFNames=T3K9.7 {ECO:0000312|EMBL:AAD11996.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAL86004.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16895613; DOI=10.1186/1471-2164-7-200;
RA Tripathi L.P., Sowdhamini R.;
RT "Cross genome comparisons of serine proteases in Arabidopsis and rice.";
RL BMC Genomics 7:200-200(2006).
RN [5]
RP GENE FAMILY.
RX PubMed=17938163; DOI=10.1101/gr.6425307;
RA Lemberg M.K., Freeman M.;
RT "Functional and evolutionary implications of enhanced genomic analysis of
RT rhomboid intramembrane proteases.";
RL Genome Res. 17:1634-1646(2007).
CC -!- FUNCTION: Probable rhomboid-type serine protease that catalyzes
CC intramembrane proteolysis. {ECO:0000303|PubMed:16895613}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the peptidase S54 family. {ECO:0000305}.
CC -!- CAUTION: Might be an inactive rhomboid-type serine protease due to
CC mismatches with the consensus active sites.
CC {ECO:0000303|PubMed:17938163}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD11996.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC004261; AAD11996.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC09939.1; -; Genomic_DNA.
DR EMBL; AY080734; AAL86004.1; -; mRNA.
DR EMBL; AY133793; AAM91727.1; -; mRNA.
DR PIR; T02103; T02103.
DR RefSeq; NP_850346.1; NM_180015.4.
DR AlphaFoldDB; Q8RXQ2; -.
DR SMR; Q8RXQ2; -.
DR STRING; 3702.AT2G41160.1; -.
DR iPTMnet; Q8RXQ2; -.
DR PaxDb; Q8RXQ2; -.
DR PRIDE; Q8RXQ2; -.
DR ProteomicsDB; 225911; -.
DR EnsemblPlants; AT2G41160.1; AT2G41160.1; AT2G41160.
DR GeneID; 818715; -.
DR Gramene; AT2G41160.1; AT2G41160.1; AT2G41160.
DR KEGG; ath:AT2G41160; -.
DR Araport; AT2G41160; -.
DR TAIR; locus:2063182; AT2G41160.
DR eggNOG; KOG4463; Eukaryota.
DR HOGENOM; CLU_057710_1_0_1; -.
DR OMA; QYWRLLV; -.
DR OrthoDB; 975575at2759; -.
DR PhylomeDB; Q8RXQ2; -.
DR PRO; PR:Q8RXQ2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8RXQ2; baseline and differential.
DR Genevisible; Q8RXQ2; AT.
DR GO; GO:0005776; C:autophagosome; IDA:TAIR.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0061908; C:phagophore; IDA:TAIR.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0010286; P:heat acclimation; IGI:TAIR.
DR Gene3D; 1.20.1540.10; -; 1.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR Pfam; PF01694; Rhomboid; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF144091; SSF144091; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
DR PROSITE; PS50030; UBA; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..287
FT /note="Rhomboid-like protein 18"
FT /id="PRO_0000433337"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 244..284
FT /note="UBA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00212"
SQ SEQUENCE 287 AA; 31690 MW; F7787782F96F5F1A CRC64;
MNGGPSGFNN APVTKAFVIA TALFTVFFGI RGGSSKLGLS YQDIFEKFRI WKLIISAFAF
SSTTQLLSGL YLLYFFRVFE RQIGSNKYSV FIFFSGFVSL ILETILLSLT KDPTANLLTS
GPYALVFASF VPFFLDIPVT KRFGVLGVHF SDKSFIYLAG VQLLLSSWKR SIFTGICGII
AGSLYRLNIF GIRKAKFPEF MASLFSRFSL PSLSSHSQPP RRTSPNLGRQ AVRAYRAPMP
STTEPSEEAI ATLVSMGFDQ NAARQALVHA RNDVNAATNI LLEAHSH
