RBL19_ARATH
ID RBL19_ARATH Reviewed; 304 AA.
AC Q8LF05; Q56X94; Q9SFB9;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Rhomboid-like protein 19 {ECO:0000303|PubMed:16895613};
DE Short=AtRBL19 {ECO:0000303|PubMed:16895613};
GN Name=RBL19 {ECO:0000303|PubMed:16895613};
GN OrderedLocusNames=At3g07950 {ECO:0000312|Araport:AT3G07950};
GN ORFNames=F17A17.29 {ECO:0000312|EMBL:AAF21205.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAM61666.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16895613; DOI=10.1186/1471-2164-7-200;
RA Tripathi L.P., Sowdhamini R.;
RT "Cross genome comparisons of serine proteases in Arabidopsis and rice.";
RL BMC Genomics 7:200-200(2006).
RN [7]
RP GENE FAMILY.
RX PubMed=17938163; DOI=10.1101/gr.6425307;
RA Lemberg M.K., Freeman M.;
RT "Functional and evolutionary implications of enhanced genomic analysis of
RT rhomboid intramembrane proteases.";
RL Genome Res. 17:1634-1646(2007).
CC -!- FUNCTION: Probable rhomboid-type serine protease that catalyzes
CC intramembrane proteolysis. {ECO:0000303|PubMed:16895613}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the peptidase S54 family. {ECO:0000305}.
CC -!- CAUTION: Might be an inactive rhomboid-type serine protease due to
CC mismatches with the consensus active sites.
CC {ECO:0000303|PubMed:17938163}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF21205.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAD93903.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC013483; AAF21205.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE74624.1; -; Genomic_DNA.
DR EMBL; BT002055; AAN72066.1; -; mRNA.
DR EMBL; BT008814; AAP68253.1; -; mRNA.
DR EMBL; AK221782; BAD93903.1; ALT_FRAME; mRNA.
DR EMBL; AY085112; AAM61666.1; -; mRNA.
DR RefSeq; NP_566326.1; NM_111674.3.
DR AlphaFoldDB; Q8LF05; -.
DR IntAct; Q8LF05; 7.
DR STRING; 3702.AT3G07950.1; -.
DR iPTMnet; Q8LF05; -.
DR PaxDb; Q8LF05; -.
DR PRIDE; Q8LF05; -.
DR ProteomicsDB; 225912; -.
DR EnsemblPlants; AT3G07950.1; AT3G07950.1; AT3G07950.
DR GeneID; 819986; -.
DR Gramene; AT3G07950.1; AT3G07950.1; AT3G07950.
DR KEGG; ath:AT3G07950; -.
DR Araport; AT3G07950; -.
DR TAIR; locus:2077377; AT3G07950.
DR eggNOG; KOG2890; Eukaryota.
DR HOGENOM; CLU_043563_0_0_1; -.
DR InParanoid; Q8LF05; -.
DR OMA; FACLFPD; -.
DR OrthoDB; 1156492at2759; -.
DR PhylomeDB; Q8LF05; -.
DR PRO; PR:Q8LF05; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8LF05; baseline and differential.
DR Genevisible; Q8LF05; AT.
DR GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR GO; GO:0000138; C:Golgi trans cisterna; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR Gene3D; 1.20.1540.10; -; 1.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR InterPro; IPR013861; TMEM115/Pdh1/Rbl19.
DR PANTHER; PTHR13377; PTHR13377; 1.
DR Pfam; PF08551; DUF1751; 1.
DR SUPFAM; SSF144091; SSF144091; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..304
FT /note="Rhomboid-like protein 19"
FT /id="PRO_0000433338"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 247..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 178
FT /note="A -> V (in Ref. 4; BAD93903)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 304 AA; 34084 MW; 2D259311363717D9 CRC64;
MSSPGTSMFT NFTKLCKGLA LVLVVGHLVV QFIPATVPYL ALIPARTIPF AWNLITSGYF
ELSVYGVVFS TVSLLFMGKF LEPVWGSTEF LKFIFVVNFL TYLCVFVTAI ALYYITRLEV
YLYMPFAGFH GVLAGLLVGI KQIIPDQEIL LLKIKAKWLP SIMLILSIAS SFFTLDSAAY
LPTLIFGTYM GWLYLRYLQR RPETKLRGDP SDDFAFSTFF PELLRPVIDP IALIFHRMLC
GRSNATSEDH DYSTSGAPLP GSDSAEASRR RERGARALEE RLGTERLVPA RNKDELQSDG
LDNV
