ID   RBL2A_PONAB             Reviewed;         229 AA.
AC   Q5R573;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Rab-like protein 2A;
GN   Name=RABL2A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an essential role in male fertility, sperm intra-
CC       flagellar transport, and tail assembly. Binds, in a GTP-regulated
CC       manner, to a specific set of effector proteins including key proteins
CC       involved in cilia development and function and delivers them into the
CC       growing sperm tail. {ECO:0000250|UniProtKB:E9Q9D5}.
CC   -!- SUBUNIT: Interacts with IFT27, IFT81, IFT172, ATP6V1E1, HK1, LDHC,
CC       MAPRE1 and HSPA2. {ECO:0000250|UniProtKB:E9Q9D5}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; CR860991; CAH93093.1; -; mRNA.
DR   RefSeq; NP_001127629.1; NM_001134157.1.
DR   AlphaFoldDB; Q5R573; -.
DR   SMR; Q5R573; -.
DR   STRING; 9601.ENSPPYP00000013385; -.
DR   GeneID; 100174708; -.
DR   KEGG; pon:100174708; -.
DR   CTD; 11158; -.
DR   eggNOG; KOG0087; Eukaryota.
DR   InParanoid; Q5R573; -.
DR   OrthoDB; 1340129at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd04124; RabL2; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041835; RabL2.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..229
FT                   /note="Rab-like protein 2A"
FT                   /id="PRO_0000280758"
FT   REGION          200..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..229
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         28..35
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         76..80
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         133..136
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   229 AA;  26067 MW;  E45CC0B8F637B87E CRC64;
     MAEHRTKPSE LDQGKCDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ LSTYALTLYK
     HTATVDGKTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV FDVQRKVTYK NLSAWYTELR
     EFRPEIPCLV VANKIDADIN VTQKSFNFAK KFSLPLYFVS AADGTNVVKL FNDAIRLAVS
     YKQNSQDFMD EILQELENFN LEQEEEDVPD QEQSGSIETP SEEVASPHS