RBL9_ARATH
ID RBL9_ARATH Reviewed; 434 AA.
AC Q9FFX0;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=RHOMBOID-like protein 9, chloroplastic {ECO:0000303|PubMed:17181860};
DE Short=AtRBL9 {ECO:0000303|PubMed:17181860};
DE EC=3.4.21.- {ECO:0000305};
DE Flags: Precursor;
GN Name=RBL9 {ECO:0000303|PubMed:17181860};
GN OrderedLocusNames=At5g38510 {ECO:0000312|Araport:AT5G38510};
GN ORFNames=MBB18.4 {ECO:0000312|EMBL:BAB10141.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kim C.J., Chen H., Cheuk R., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16895613; DOI=10.1186/1471-2164-7-200;
RA Tripathi L.P., Sowdhamini R.;
RT "Cross genome comparisons of serine proteases in Arabidopsis and rice.";
RL BMC Genomics 7:200-200(2006).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17181860; DOI=10.1186/1471-2229-6-30;
RA Garcia-Lorenzo M., Sjodin A., Jansson S., Funk C.;
RT "Protease gene families in Populus and Arabidopsis.";
RL BMC Plant Biol. 6:30-30(2006).
RN [7]
RP GENE FAMILY.
RX PubMed=17938163; DOI=10.1101/gr.6425307;
RA Lemberg M.K., Freeman M.;
RT "Functional and evolutionary implications of enhanced genomic analysis of
RT rhomboid intramembrane proteases.";
RL Genome Res. 17:1634-1646(2007).
RN [8]
RP REVIEW.
RX PubMed=22007993; DOI=10.1111/j.1399-3054.2011.01532.x;
RA Knopf R.R., Adam Z.;
RT "Rhomboid proteases in plants - still in square one?";
RL Physiol. Plantarum 145:41-51(2012).
CC -!- FUNCTION: Probable rhomboid-type serine protease that catalyzes
CC intramembrane proteolysis. {ECO:0000303|PubMed:22007993}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane {ECO:0000255};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the peptidase S54 family. {ECO:0000305}.
CC -!- CAUTION: Might be an inactive rhomboid-type serine protease due to
CC mismatches with the consensus active sites.
CC {ECO:0000303|PubMed:17938163}.
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DR EMBL; AB005231; BAB10141.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94327.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94328.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68896.1; -; Genomic_DNA.
DR EMBL; BT012562; AAS99706.1; -; mRNA.
DR EMBL; AK226685; BAE98792.1; -; mRNA.
DR RefSeq; NP_001078681.1; NM_001085212.2.
DR RefSeq; NP_001330612.1; NM_001344253.1.
DR RefSeq; NP_198667.1; NM_123212.3.
DR AlphaFoldDB; Q9FFX0; -.
DR STRING; 3702.AT5G38510.1; -.
DR PaxDb; Q9FFX0; -.
DR PRIDE; Q9FFX0; -.
DR ProteomicsDB; 225971; -.
DR EnsemblPlants; AT5G38510.1; AT5G38510.1; AT5G38510.
DR EnsemblPlants; AT5G38510.2; AT5G38510.2; AT5G38510.
DR EnsemblPlants; AT5G38510.3; AT5G38510.3; AT5G38510.
DR GeneID; 833839; -.
DR Gramene; AT5G38510.1; AT5G38510.1; AT5G38510.
DR Gramene; AT5G38510.2; AT5G38510.2; AT5G38510.
DR Gramene; AT5G38510.3; AT5G38510.3; AT5G38510.
DR KEGG; ath:AT5G38510; -.
DR Araport; AT5G38510; -.
DR TAIR; locus:2159808; AT5G38510.
DR eggNOG; KOG2289; Eukaryota.
DR HOGENOM; CLU_043890_0_0_1; -.
DR InParanoid; Q9FFX0; -.
DR OMA; VGHEINR; -.
DR OrthoDB; 1253228at2759; -.
DR PhylomeDB; Q9FFX0; -.
DR PRO; PR:Q9FFX0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FFX0; baseline and differential.
DR Genevisible; Q9FFX0; AT.
DR GO; GO:0031969; C:chloroplast membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0006465; P:signal peptide processing; IBA:GO_Central.
DR Gene3D; 1.20.1540.10; -; 1.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR Pfam; PF01694; Rhomboid; 1.
DR SUPFAM; SSF144091; SSF144091; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Hydrolase; Membrane; Plastid; Protease; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..68
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 69..434
FT /note="RHOMBOID-like protein 9, chloroplastic"
FT /id="PRO_0000433330"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 434 AA; 47727 MW; E8951EDFC3CF60E6 CRC64;
MALFPLHHEV PCKGEVLFDS NGLRRFSSGL KHRTMAEATT LGRDCRMKSY MKSIPYCRSP
RRRLCLVRAS SENKITKQRL KLLDSYFGKL QNDDEKPSIS TGDDIDRKAE LNVNEELDSL
SAYLDKLQKD AKSKGLVSST LDVVKSEGGS VASKLRKTGI ENNNSPFQQF DDEDQAEDTL
NFYAVSILAS INVGVCLFEA AAPVRNNNMG LLSLPLLYGA KINDLILAGE WWRLVTPMFL
HSGIPHVALS SWALLTFGPK VCRDYGLFTF CLIYILGGVS GNFMSFLHTA DPTVGGTGPA
FALIGAWLVD QNQNKEMIKS NEYEDLFQKA IIMTGFGLIL SHFGPIDDWT NLGALIAGIV
YGFFTCPVLQ LGSGGSERQE GIVTVGPEKQ NSADPCKSFL LFTIFVAVIV TSLLLIGDGP
LDFPTYDDVV YSLI
