AAER_ECO57
ID AAER_ECO57 Reviewed; 309 AA.
AC P67664; P45691;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=HTH-type transcriptional activator AaeR;
GN Name=aaeR; OrderedLocusNames=Z4602, ECs4116;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Activates transcription of the aaeXAB operon. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; AE005174; AAG58371.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB37539.1; -; Genomic_DNA.
DR PIR; D91143; D91143.
DR RefSeq; NP_312143.1; NC_002695.1.
DR RefSeq; WP_000440317.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; P67664; -.
DR SMR; P67664; -.
DR STRING; 155864.EDL933_4465; -.
DR EnsemblBacteria; AAG58371; AAG58371; Z4602.
DR EnsemblBacteria; BAB37539; BAB37539; ECs_4116.
DR GeneID; 67415925; -.
DR GeneID; 916027; -.
DR KEGG; ece:Z4602; -.
DR KEGG; ecs:ECs_4116; -.
DR PATRIC; fig|386585.9.peg.4297; -.
DR eggNOG; COG0583; Bacteria.
DR HOGENOM; CLU_039613_16_2_6; -.
DR OMA; KHRYITH; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..309
FT /note="HTH-type transcriptional activator AaeR"
FT /id="PRO_0000105582"
FT DOMAIN 1..59
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 19..38
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ SEQUENCE 309 AA; 34516 MW; 22DF64653AF4BE2F CRC64;
MERLKRMSVF AKVVEFGSFT AAARQLQMSV SSISQTVSKL EDELQVKLLN RSTRSIGLTE
AGRIYYQGCR RMLHEVQDVH EQLYAFNNTP IGTLRIGCSS TMAQNVLAGL TAKMLKEYPG
LSVNLVTGIP APDLIADGLD VVIRVGALQD SSLFSRRLGA MPMVVCAAKS YLTQYGIPEK
PADLSSHSWL EYSVRPDNEF ELIAPEGIST RLIPQGRFVT NDPMTLVRWL TAGAGIAYVP
LMWVINEINR GELEILLPRY QSDPRPVYAL YTEKDKLPLK VQVVINSLTD YFVEVGKLFQ
EMHGRGKEK
