AAER_ECOLI
ID AAER_ECOLI Reviewed; 309 AA.
AC P67662; P45691; Q2M8X0;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=HTH-type transcriptional activator AaeR;
GN Name=aaeR; Synonyms=yhcS; OrderedLocusNames=b3243, JW3212;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP FUNCTION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15489430; DOI=10.1128/jb.186.21.7196-7204.2004;
RA Van Dyk T.K., Templeton L.J., Cantera K.A., Sharpe P.L., Sariaslani F.S.;
RT "Characterization of the Escherichia coli AaeAB efflux pump: a metabolic
RT relief valve?";
RL J. Bacteriol. 186:7196-7204(2004).
CC -!- FUNCTION: Activates transcription of the aaeXAB operon.
CC {ECO:0000269|PubMed:15489430}.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; U18997; AAA58045.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76275.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77286.1; -; Genomic_DNA.
DR PIR; E65116; E65116.
DR RefSeq; NP_417710.1; NC_000913.3.
DR RefSeq; WP_000440317.1; NZ_STEB01000012.1.
DR AlphaFoldDB; P67662; -.
DR SMR; P67662; -.
DR BioGRID; 4260796; 7.
DR DIP; DIP-12291N; -.
DR IntAct; P67662; 3.
DR STRING; 511145.b3243; -.
DR PaxDb; P67662; -.
DR PRIDE; P67662; -.
DR EnsemblBacteria; AAC76275; AAC76275; b3243.
DR EnsemblBacteria; BAE77286; BAE77286; BAE77286.
DR GeneID; 67415925; -.
DR GeneID; 947760; -.
DR KEGG; ecj:JW3212; -.
DR KEGG; eco:b3243; -.
DR PATRIC; fig|1411691.4.peg.3485; -.
DR EchoBASE; EB2676; -.
DR eggNOG; COG0583; Bacteria.
DR HOGENOM; CLU_039613_16_2_6; -.
DR InParanoid; P67662; -.
DR OMA; KHRYITH; -.
DR PhylomeDB; P67662; -.
DR BioCyc; EcoCyc:G7688-MON; -.
DR PRO; PR:P67662; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006352; P:DNA-templated transcription, initiation; IMP:EcoliWiki.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:EcoCyc.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:EcoliWiki.
DR GO; GO:0006351; P:transcription, DNA-templated; IMP:EcoCyc.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..309
FT /note="HTH-type transcriptional activator AaeR"
FT /id="PRO_0000105580"
FT DOMAIN 1..59
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 19..38
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ SEQUENCE 309 AA; 34516 MW; 22DF64653AF4BE2F CRC64;
MERLKRMSVF AKVVEFGSFT AAARQLQMSV SSISQTVSKL EDELQVKLLN RSTRSIGLTE
AGRIYYQGCR RMLHEVQDVH EQLYAFNNTP IGTLRIGCSS TMAQNVLAGL TAKMLKEYPG
LSVNLVTGIP APDLIADGLD VVIRVGALQD SSLFSRRLGA MPMVVCAAKS YLTQYGIPEK
PADLSSHSWL EYSVRPDNEF ELIAPEGIST RLIPQGRFVT NDPMTLVRWL TAGAGIAYVP
LMWVINEINR GELEILLPRY QSDPRPVYAL YTEKDKLPLK VQVVINSLTD YFVEVGKLFQ
EMHGRGKEK
