ID   RBM12_MACMU             Reviewed;         932 AA.
AC   Q8SQ27;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=RNA-binding protein 12;
DE   AltName: Full=RNA-binding motif protein 12;
DE   AltName: Full=SH3/WW domain anchor protein in the nucleus;
DE            Short=SWAN;
GN   Name=RBM12;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang C.-H.;
RT   "SWAN, a multidomain nuclear protein in mammalian species.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; AF345333; AAL83753.1; -; mRNA.
DR   RefSeq; NP_001028012.1; NM_001032840.1.
DR   AlphaFoldDB; Q8SQ27; -.
DR   SMR; Q8SQ27; -.
DR   Ensembl; ENSMMUT00000078457; ENSMMUP00000053163; ENSMMUG00000020960.
DR   GeneID; 574161; -.
DR   KEGG; mcc:574161; -.
DR   CTD; 10137; -.
DR   VEuPathDB; HostDB:ENSMMUG00000020960; -.
DR   eggNOG; KOG4307; Eukaryota.
DR   GeneTree; ENSGT00940000160611; -.
DR   InParanoid; Q8SQ27; -.
DR   OrthoDB; 249376at2759; -.
DR   Proteomes; UP000006718; Chromosome 10.
DR   Bgee; ENSMMUG00000020960; Expressed in ileum and 21 other tissues.
DR   ExpressionAtlas; Q8SQ27; baseline.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0043484; P:regulation of RNA splicing; IBA:GO_Central.
DR   CDD; cd12745; RRM1_RBM12; 1.
DR   CDD; cd12747; RRM2_RBM12; 1.
DR   CDD; cd12512; RRM3_RBM12; 1.
DR   CDD; cd12749; RRM4_RBM12; 1.
DR   CDD; cd12751; RRM5_RBM12; 1.
DR   Gene3D; 3.30.70.330; -; 5.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034591; RBM12_RRM1.
DR   InterPro; IPR034594; RBM12_RRM2.
DR   InterPro; IPR034855; RBM12_RRM3.
DR   InterPro; IPR034856; RBM12_RRM4.
DR   InterPro; IPR034854; RBM12_RRM5.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 3.
DR   SMART; SM00360; RRM; 4.
DR   SUPFAM; SSF54928; SSF54928; 4.
DR   PROSITE; PS50102; RRM; 3.
PE   2: Evidence at transcript level;
KW   Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..932
FT                   /note="RNA-binding protein 12"
FT                   /id="PRO_0000081771"
FT   DOMAIN          304..379
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          430..507
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          856..932
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          97..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          393..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          717..853
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        822..840
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         352
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NTZ6"
FT   MOD_RES         375
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NTZ6"
FT   MOD_RES         420
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NTZ6"
FT   MOD_RES         422
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NTZ6"
FT   MOD_RES         424
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NTZ6"
FT   MOD_RES         525
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NTZ6"
SQ   SEQUENCE   932 AA;  97383 MW;  946D6D5FBB67A1DF CRC64;
     MAVVIRLQGL PIVAGTMDIR HFFSGLTIPD GGVHIVGGEL GEAFIVFATD EDARLGMMRT
     GGTIKGSKVT LLLSSKTEMQ NMIELSRRRF ETANLDIPPA NASRSGPPPS SGMSGRVNLP
     TTVSNFNNPS PSVVTATTSV HESNKNIQTF STASIGTAPP NMGASFGSPT FSSTVPSTAS
     PMNTVPPPPI PPIPAMPSLP PMPSIPPIPV PPPVPTLPPV PPVPPIPPVP SVPPMTPLPP
     MSGMPPLNPP PVAPLPAGMN GSGAPMNLNN NLNPMFLGPL NPVNPIQMNS QSSVKPLPIN
     PDDLYVSVHG MPFSAMENDV RDFFHGLRVD AVHLLKDHVG RNNGNGLVKF LSPQDTFEAL
     KRNRMLMIQR YVEVSPATER QWVAAGGHIT FKQNMGPSGQ SHPPPQTLPR SKSPSGQKRS
     RSRSPHEAGF CVYLKGLPFE AENKHVIDFF KKLDIVEDSI YIAYGPNGKA TGEGFVEFRN
     EADYKAALCR HKQYMGNRFI QVHPITKKGM LEKIDMIRKR LQNFSYDQRE MMLNPEGDVN
     SAKVCAHITN IPFSITKMDV LQFLEGIPVD ENAVHVLVDN NGQGLGQALV QFKNEDDARK
     SERLHRKKLN GREAFVHVVT LEDMREIEKN PPAQGKKGLK MPVPGNPAVP GMPNAGLPGV
     GLPSAGLPGA GLPSTGLPGS AITSAGLPGA GMPSAGIPSA GGEEHAFLTV GSKEANNGPP
     FNFPGNFGGS NAFGPPIPPP GLGGGAFGDA RPGMPSVGNS GLPGLGLDVP GFGGGPNNLS
     GPSGFGGGPQ NFGNGPGSLG GPPGFGSGPP GLGSAPGHLG GPPAFGPGPG PGPGPGPIHI
     GGPPGFASSS GKPGPTVIKV QNMPFTVSID EILDFFYGYQ VIPGSVCLKY NEKGMPTGEA
     MVAFESRDEA TAAVIDLNDR PIGSRKVKLV LG