RBM18_MOUSE
ID RBM18_MOUSE Reviewed; 190 AA.
AC Q9CR83; Q8CBD4;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Probable RNA-binding protein 18;
DE AltName: Full=RNA-binding motif protein 18;
GN Name=Rbm18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Small intestine, and Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK008110; BAB25466.1; -; mRNA.
DR EMBL; AK021243; BAB32344.1; -; mRNA.
DR EMBL; AK035348; BAC29043.1; -; mRNA.
DR EMBL; AK036252; BAC29361.1; -; mRNA.
DR EMBL; BC005540; AAH05540.1; -; mRNA.
DR CCDS; CCDS15969.1; -.
DR RefSeq; NP_001153107.1; NM_001159635.1.
DR RefSeq; NP_080710.1; NM_026434.4.
DR AlphaFoldDB; Q9CR83; -.
DR SMR; Q9CR83; -.
DR STRING; 10090.ENSMUSP00000028251; -.
DR iPTMnet; Q9CR83; -.
DR PhosphoSitePlus; Q9CR83; -.
DR EPD; Q9CR83; -.
DR MaxQB; Q9CR83; -.
DR PaxDb; Q9CR83; -.
DR PeptideAtlas; Q9CR83; -.
DR PRIDE; Q9CR83; -.
DR ProteomicsDB; 255120; -.
DR Antibodypedia; 44495; 26 antibodies from 9 providers.
DR DNASU; 67889; -.
DR Ensembl; ENSMUST00000028251; ENSMUSP00000028251; ENSMUSG00000026889.
DR GeneID; 67889; -.
DR KEGG; mmu:67889; -.
DR UCSC; uc008jlh.2; mouse.
DR CTD; 92400; -.
DR MGI; MGI:1915139; Rbm18.
DR VEuPathDB; HostDB:ENSMUSG00000026889; -.
DR eggNOG; ENOG502RH7I; Eukaryota.
DR GeneTree; ENSGT00390000013765; -.
DR HOGENOM; CLU_066926_2_0_1; -.
DR InParanoid; Q9CR83; -.
DR OMA; APYRFQL; -.
DR OrthoDB; 1566886at2759; -.
DR PhylomeDB; Q9CR83; -.
DR TreeFam; TF323314; -.
DR BioGRID-ORCS; 67889; 9 hits in 72 CRISPR screens.
DR ChiTaRS; Rbm18; mouse.
DR PRO; PR:Q9CR83; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9CR83; protein.
DR Bgee; ENSMUSG00000026889; Expressed in secondary oocyte and 260 other tissues.
DR ExpressionAtlas; Q9CR83; baseline and differential.
DR Genevisible; Q9CR83; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0045171; C:intercellular bridge; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR CDD; cd12355; RRM_RBM18; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR039157; RBM18_RRM.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; RNA-binding.
FT CHAIN 1..190
FT /note="Probable RNA-binding protein 18"
FT /id="PRO_0000254123"
FT DOMAIN 25..106
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 166..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 35
FT /note="K -> R (in Ref. 1; BAC29361)"
FT /evidence="ECO:0000305"
FT CONFLICT 148
FT /note="A -> S (in Ref. 1; BAC29361)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 190 AA; 21649 MW; 12E39C54DFB4803B CRC64;
METETKTLPL ENASILSEGS LQEGHRLWIG NLDPKITEYH LLKLLQKFGK VKQFDFLFHK
SGALEGQPRG YCFVNFETKQ EAEQAIQCLN GKLALSKKLV VRWAHAQVKR YDHNKNDKIL
PISLEPSSST EPAQSNLSVT AKIKAIEAKL KMMAENPDAE YPAAPVYSYF KPPDKKRTTP
YSRTAWKSRR
