RBM22_PLAF7
ID RBM22_PLAF7 Reviewed; 357 AA.
AC Q8I4V2; A0A144A0M5;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Pre-mRNA-splicing factor RBM22 homolog;
GN Name=RBM22 {ECO:0000305}; ORFNames=PF3D7_1248200, PFL2310w;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000305}
RP SYNTHESIS OF 117-146, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- FUNCTION: Involved in pre-mRNA splicing (By similarity). Binds RNA (By
CC similarity). {ECO:0000250|UniProtKB:P38241}.
CC -!- SUBUNIT: Probable component of the spliceosome C complex.
CC {ECO:0000250|UniProtKB:P38241}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P38241}.
CC -!- DOMAIN: The C-terminal RRM domain and the zinc finger motif are
CC necessary for RNA-binding. {ECO:0000250}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
CC -!- SIMILARITY: Belongs to the SLT11 family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN999947; CZT99637.1; -; Genomic_DNA.
DR RefSeq; XP_001350866.1; XM_001350830.2.
DR AlphaFoldDB; Q8I4V2; -.
DR SMR; Q8I4V2; -.
DR STRING; 5833.PFL2310w; -.
DR EnsemblProtists; CZT99637; CZT99637; PF3D7_1248200.
DR GeneID; 811514; -.
DR KEGG; pfa:PF3D7_1248200; -.
DR VEuPathDB; PlasmoDB:PF3D7_1248200; -.
DR HOGENOM; CLU_027112_0_0_1; -.
DR InParanoid; Q8I4V2; -.
DR OMA; PYFRKGR; -.
DR PhylomeDB; Q8I4V2; -.
DR Proteomes; UP000001450; Chromosome 12.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IBA:GO_Central.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0036002; F:pre-mRNA binding; IBA:GO_Central.
DR GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR039171; Cwc2/Slt11.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR14089; PTHR14089; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR SUPFAM; SSF90229; SSF90229; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 1: Evidence at protein level;
KW Merozoite; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; RNA-binding; Spliceosome; Zinc; Zinc-finger.
FT CHAIN 1..357
FT /note="Pre-mRNA-splicing factor RBM22 homolog"
FT /id="PRO_0000388756"
FT DOMAIN 222..295
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT ZN_FING 153..180
FT /note="C3H1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
SQ SEQUENCE 357 AA; 41968 MW; A5A4A21F9307049A CRC64;
MDRYGHNVRS DIKKQGYEDS NLPILCETCL GENPYVRIIR EENGKECKIC KNVFTHFRWK
PGENSRYKQT VICMKCAKVK NVCQTCLFDL QYNLPVQVRD KFLENSIVLP ENETNRNFFL
EQMENDMSST YDKMNRINMD LSKLKRRDPY FKRNMARVCS FWRKNSCNRG DECPYLHKEI
HLDKSLSNQN IKNRYTGEND ILAEKILLKH NEKNNDDKNM SNKICIQGIS ESVSQANIKE
CFKKFGDIKS IKVIPKDSKM FISYSNSQAA KKASDKYKDG LLLNGCNLTV HLQDNPTYNN
KNQQPVINYM NNNMYQNNMS PQMMYNPMYY PYYNMNNMHP SSAPYSSMLP SEAEQRK
