RBM24_XENTR
ID RBM24_XENTR Reviewed; 226 AA.
AC Q6P8A7;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=RNA-binding protein 24 {ECO:0000305};
DE AltName: Full=RNA-binding motif protein 24 {ECO:0000250|UniProtKB:Q9BX46};
GN Name=rbm24;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Multifunctional RNA-binding protein involved in the
CC regulation of pre-mRNA splicing, mRNA stability and mRNA translation
CC important for cell fate decision and differentiation. Plays a major
CC role in pre-mRNA alternative splicing regulation. Mediates
CC preferentially muscle-specific exon inclusion in numerous mRNAs
CC important for striated cardiac and skeletal muscle cell
CC differentiation. Binds to intronic splicing enhancer (ISE) composed of
CC stretches of GU-rich motifs localized in flanking intron of exon that
CC will be included by alternative splicing. Involved in embryonic stem
CC cell (ESC) transition to cardiac cell differentiation by promoting pre-
CC mRNA alternative splicing events of several pluripotency and/or
CC differentiation genes. Plays a role in the regulation of mRNA stability
CC and mRNA translation to which it is bound. Involved in myogenic
CC differentiation by regulating myog levels. Binds to a huge amount of
CC mRNAs. Required for embryonic heart development, sarcomer and M-band
CC formation in striated muscles. {ECO:0000250|UniProtKB:D3Z4I3,
CC ECO:0000250|UniProtKB:Q9BX46}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6GQD3}. Cytoplasm
CC {ECO:0000250|UniProtKB:D3Z4I3}.
CC -!- DOMAIN: The RRM domain is necessary for mRNA stability and mRNA
CC translation regulation. {ECO:0000250|UniProtKB:Q9BX46}.
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DR EMBL; BC061322; AAH61322.1; -; mRNA.
DR RefSeq; NP_989016.1; NM_203685.1.
DR AlphaFoldDB; Q6P8A7; -.
DR SMR; Q6P8A7; -.
DR STRING; 8364.ENSXETP00000053069; -.
DR PaxDb; Q6P8A7; -.
DR DNASU; 394612; -.
DR Ensembl; ENSXETT00000053069; ENSXETP00000053069; ENSXETG00000024618.
DR GeneID; 394612; -.
DR KEGG; xtr:394612; -.
DR CTD; 221662; -.
DR Xenbase; XB-GENE-493647; rbm24.
DR eggNOG; KOG0149; Eukaryota.
DR HOGENOM; CLU_065652_0_1_1; -.
DR InParanoid; Q6P8A7; -.
DR OrthoDB; 1579773at2759; -.
DR PhylomeDB; Q6P8A7; -.
DR Proteomes; UP000008143; Chromosome 6.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000024618; Expressed in skeletal muscle tissue and 16 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; ISS:UniProtKB.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; ISS:UniProtKB.
DR GO; GO:1990715; F:mRNA CDS binding; ISS:UniProtKB.
DR GO; GO:0097157; F:pre-mRNA intronic binding; ISS:UniProtKB.
DR GO; GO:1990825; F:sequence-specific mRNA binding; ISS:UniProtKB.
DR GO; GO:0061158; P:3'-UTR-mediated mRNA destabilization; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR GO; GO:0061157; P:mRNA destabilization; ISS:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0048255; P:mRNA stabilization; ISS:UniProtKB.
DR GO; GO:2000766; P:negative regulation of cytoplasmic translation; ISS:UniProtKB.
DR GO; GO:1905870; P:positive regulation of 3'-UTR-mediated mRNA stabilization; ISS:UniProtKB.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; ISS:UniProtKB.
DR GO; GO:0010831; P:positive regulation of myotube differentiation; ISS:UniProtKB.
DR GO; GO:1902811; P:positive regulation of skeletal muscle fiber differentiation; ISS:UniProtKB.
DR GO; GO:2000738; P:positive regulation of stem cell differentiation; ISS:UniProtKB.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0043488; P:regulation of mRNA stability; ISS:UniProtKB.
DR GO; GO:0010830; P:regulation of myotube differentiation; ISS:UniProtKB.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Differentiation; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; RNA-binding; Translation regulation.
FT CHAIN 1..226
FT /note="RNA-binding protein 24"
FT /id="PRO_0000273375"
FT DOMAIN 11..88
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ SEQUENCE 226 AA; 24136 MW; 2542F10C6FE1FD72 CRC64;
MHTTQKDTTY TKIFVGGLPY HTTDSSLRKY FEVFGDIEEA VVITDRQTGK SRGYGFVTMA
DRAAAERACK DPNPIIDGRK ANVNLAYLGA KPRIMQPGFA FGVQQIHPAL IQRPFGIPAH
YVYPHAFVQP GVVIPHVQQA AAASTSPYID YTSAAYAQYS AAAAAAAAYD QYPYAASPAT
TGYVTTAGYG YAVPQPLTAA APGTAAAAAA AFGQYQPQQL QADRMQ
