RBM26_XENLA
ID RBM26_XENLA Reviewed; 1059 AA.
AC Q2T9I5; Q7ZYK7;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=RNA-binding protein 26;
DE AltName: Full=RNA-binding motif protein 26;
GN Name=rbm26;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Embryo, and Oocyte;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2T9I5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2T9I5-2; Sequence=VSP_022536;
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DR EMBL; BC043744; AAH43744.1; -; mRNA.
DR EMBL; BC111508; AAI11509.1; -; mRNA.
DR RefSeq; NP_001079468.1; NM_001085999.1.
DR AlphaFoldDB; Q2T9I5; -.
DR SMR; Q2T9I5; -.
DR DNASU; 379155; -.
DR GeneID; 379155; -.
DR KEGG; xla:379155; -.
DR CTD; 379155; -.
DR Xenbase; XB-GENE-960059; rbm26.S.
DR OrthoDB; 741871at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 379155; Expressed in gastrula and 19 other tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR CDD; cd12516; RRM1_RBM26; 1.
DR CDD; cd12258; RRM2_RBM26_like; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR002483; PWI_dom.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034861; RBM26.
DR InterPro; IPR039511; RBM26-like_RRM2.
DR InterPro; IPR045137; RBM26/27.
DR InterPro; IPR034859; RBM26_RRM1.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR14398; PTHR14398; 1.
DR PANTHER; PTHR14398:SF2; PTHR14398:SF2; 1.
DR Pfam; PF01480; PWI; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 2.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF54928; SSF54928; 2.
DR SUPFAM; SSF90229; SSF90229; 1.
DR PROSITE; PS50102; RRM; 2.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Metal-binding; Reference proteome;
KW Repeat; RNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..1059
FT /note="RNA-binding protein 26"
FT /id="PRO_0000273378"
FT DOMAIN 581..655
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 942..1011
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT ZN_FING 327..355
FT /note="C3H1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 98..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 771..873
FT /evidence="ECO:0000255"
FT COMPBIAS 98..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..432
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1051
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 466..467
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_022536"
FT CONFLICT 712
FT /note="T -> I (in Ref. 1; AAH43744)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1059 AA; 118877 MW; 37F4E6E09C5B3C1B CRC64;
MIIEDFEALK HWLSKTLEPI CDADPSALAK YVLALVKKDK SDRELNALCI DQLDVFLQKE
TQGFVDKLFD AINTKSYLPQ PDSTSTAVVK LDSFEHQEKE IKKDEVNKEE EKEKKAPRRL
NQSPQPSSTR HKDTRENRKR SNSDRESNSI QNSFRSGLPE QKQDVDAAPP RLNSNKVQNA
KNTRSRDDRK RDDRFRKREY DRNVPRRDSY RDRYNRRRGR SRSYSRSRSR SWSKERQRDR
DRSRSRTRSR DKDSGKPKFD LDRPDPVDNS YASGSSVPHI GSAHFPVPTL SSTITVITPS
HHGNSSAENW PEFHEDQVDH SSYGRLQMQK KRCRDYDEKG FCMRGDMCPF DHGSDPVVVE
DVNLPGILPF PAPPPVLEGP PPPGLPPPPS LLTPPPVNLQ PPPVPPPGPL PPSLPPVTGP
PPPLPPLQPA GMDAPPNSAT SSVPTVVTTG ILHPPPVPPS SLFPSAAAAA GPIPLFPETY
EADGYNPEAP SMTTTSRPLY RHRVHAQRPN LIGLTSGDMD LPTPREKNNM RIVVDSESRK
RNLGSGDCVL PSKKPWFDKS NFNNRMNPGF QKKPLFPNEN TKLELRRIPP ELNNISKLNE
HFSKFGTIVN LQVAYKGDPE GALIQFATHG EAKKAISSTE AVLNNRFIRM YWHREGSSQQ
LQTPGLPKVV HLTVPQQPNL SVMKQSIKER LGPVPANNSE PSVAQNINTE TTQNIAKVPV
KERLGYMSKT VSAATEKVFS TSTGLTKTVY NPAALKAMQK SVLYPICNDN GDAQKKKQEA
LKLQQDVRKK KQEILEKRIE TQKILISKLE KNKNMKSEDK AEILKTLETL TNSITKLRDE
LKAVSSTGNV VKNNKSKAQM QKELLDTELD LYNKIQAGDD VTELRKKYTE LQLDAAKRGI
LSSGRGRGVH LRGRGVIRGR GRVLHGRGRG ASVHAVVDHR PRALKISGFT EGDREYLLPH
FAHFGEIEDC QIDDSSLHAI ITFKTRAEAE AAAVHGAQFK GQDLKLAWNK PVPNASSTEV
EDADQEEEEF HEDSIVDDSL LQDDDEEEED DNESRSWRR
