ID   RBM38_XENLA             Reviewed;         214 AA.
AC   Q7T3I7; Q6GQF2;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=RNA-binding protein 38;
DE   AltName: Full=RNA-binding motif protein 38;
DE   AltName: Full=RNA-binding protein XSeb4R;
GN   Name=rbm38; Synonyms=xseb4r;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=14736748; DOI=10.1242/dev.00983;
RA   Boy S., Souopgui J., Amato M.A., Wegnez M., Pieler T., Perron M.;
RT   "XSEB4R, a novel RNA-binding protein involved in retinal cell
RT   differentiation downstream of bHLH proneural genes.";
RL   Development 131:851-862(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, RNA-BINDING, AND SUBCELLULAR LOCATION.
RX   PubMed=18765788; DOI=10.1101/gad.479808;
RA   Souopgui J., Rust B., Vanhomwegen J., Heasman J., Henningfeld K.A.,
RA   Bellefroid E., Pieler T.;
RT   "The RNA-binding protein XSeb4R: a positive regulator of VegT mRNA
RT   stability and translation that is required for germ layer formation in
RT   Xenopus.";
RL   Genes Dev. 22:2347-2352(2008).
CC   -!- FUNCTION: RNA-binding protein that specifically bind the 3'-UTR of VegT
CC       transcripts, leading to maintain their stability and stimulate their
CC       translation, thereby playing a role in germ layer formation. VegT is a
CC       localized maternal determinant essentially required for endoderm
CC       formation. Also has some proneural function in the open neural plate
CC       and in the context of retinogenesis. May also act as a mRNA splicing
CC       factor. May play a role in myogenic differentiation.
CC       {ECO:0000269|PubMed:14736748, ECO:0000269|PubMed:18765788}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in the nervous system. Expressed
CC       at early neurula stages of development. {ECO:0000269|PubMed:14736748}.
CC   -!- SIMILARITY: Belongs to the RBM38 family. {ECO:0000305}.
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DR   EMBL; AY289193; AAP42281.1; -; mRNA.
DR   EMBL; BC072792; AAH72792.1; -; mRNA.
DR   RefSeq; NP_001082613.1; NM_001089144.1.
DR   AlphaFoldDB; Q7T3I7; -.
DR   SMR; Q7T3I7; -.
DR   DNASU; 398603; -.
DR   GeneID; 398603; -.
DR   KEGG; xla:398603; -.
DR   CTD; 398603; -.
DR   Xenbase; XB-GENE-6077629; rbm38.L.
DR   OrthoDB; 1579773at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 398603; Expressed in ovary and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Differentiation; mRNA processing;
KW   mRNA splicing; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..214
FT                   /note="RNA-binding protein 38"
FT                   /id="PRO_0000355184"
FT   DOMAIN          11..88
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   CONFLICT        126
FT                   /note="T -> A (in Ref. 1; AAP42281)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   214 AA;  23747 MW;  C0A9011770D43AF2 CRC64;
     MHTVQKDTTF TKIFVGGLPY HTTDASLRKY FEVFGDIDEA VVITDRQTAK SRGYGFVTMS
     DRAAAERACK DPNPIIDGRK ANVNLAYLGA KPRNLQSAFT IGVQQLHPAF IQRPFGLTPQ
     YIYPPTIVQP SMVIPTPIPS LQSPYIDYNA ATQAYTHYTT AAYEQYPYAA SPATGYMGYG
     YTSPVQQPLS TTTGAPPTAY IQYQPQQLQP DRMQ