RBM38_XENTR
ID RBM38_XENTR Reviewed; 219 AA.
AC Q6DIV4;
DT 25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=RNA-binding protein 38;
DE AltName: Full=RNA-binding motif protein 38;
GN Name=rbm38; ORFNames=TTpA006f23.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tadpole;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding protein that specifically bind the 3'-UTR of VegT
CC transcripts, leading to maintain their stability and stimulate their
CC translation, thereby playing a role in germ layer formation. VegT is a
CC localized maternal determinant essentially required for endoderm
CC formation. Also has some proneural function in the open neural plate
CC and in the context of retinogenesis. May also act as a mRNA splicing
CC factor. May play a role in myogenic differentiation (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RBM38 family. {ECO:0000305}.
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DR EMBL; CR848225; CAJ82907.1; -; mRNA.
DR EMBL; BC075431; AAH75431.1; -; mRNA.
DR RefSeq; NP_001006916.1; NM_001006915.1.
DR AlphaFoldDB; Q6DIV4; -.
DR SMR; Q6DIV4; -.
DR PaxDb; Q6DIV4; -.
DR DNASU; 448763; -.
DR Ensembl; ENSXETT00000024600; ENSXETP00000024600; ENSXETG00000011268.
DR GeneID; 448763; -.
DR KEGG; xtr:448763; -.
DR CTD; 55544; -.
DR Xenbase; XB-GENE-489545; rbm38.
DR eggNOG; KOG0149; Eukaryota.
DR HOGENOM; CLU_065652_0_1_1; -.
DR InParanoid; Q6DIV4; -.
DR OrthoDB; 1579773at2759; -.
DR PhylomeDB; Q6DIV4; -.
DR Proteomes; UP000008143; Chromosome 10.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000011268; Expressed in 4-cell stage embryo and 13 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0048255; P:mRNA stabilization; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Differentiation; mRNA processing;
KW mRNA splicing; Nucleus; Reference proteome; RNA-binding.
FT CHAIN 1..219
FT /note="RNA-binding protein 38"
FT /id="PRO_0000355185"
FT DOMAIN 11..88
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ SEQUENCE 219 AA; 24074 MW; 237D341FD0DAF2C0 CRC64;
MHTVQKDTTF TKIFVGGLPY HTTDASLRKY FEVFGDIDEA VVITDRQTGK SRGYGFVTMS
DRAAAERACK DPNPIIDGRK ANVNLAYLGA KPRNLQSAFT IGVQQLHPAF IQRPFGLTPQ
YIYPPAIVQP SVVIPTPIPS LQSPYIDYNA ATQAFTHYTT AAYEQYPYAA SPATGYMGYG
YTSAVQQPLS ATTTTATTGA PPTAYIQYQP QQLQPDRMQ
