ID   RBM41_DANRE             Reviewed;         419 AA.
AC   Q6IQ97; Q7ZV02;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=RNA-binding protein 4.1;
DE   AltName: Full=RNA-binding motif protein 4.1;
GN   Name=rbm4.1; Synonyms=rbm4;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18307296; DOI=10.1021/pr700667w;
RA   Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA   Slijper M., Heck A.J.R.;
RT   "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT   analysis down to a single embryo.";
RL   J. Proteome Res. 7:1555-1564(2008).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC046057; AAH46057.1; -; mRNA.
DR   EMBL; BC071513; AAH71513.1; -; mRNA.
DR   RefSeq; NP_955999.1; NM_199705.1.
DR   AlphaFoldDB; Q6IQ97; -.
DR   SMR; Q6IQ97; -.
DR   STRING; 7955.ENSDARP00000052861; -.
DR   iPTMnet; Q6IQ97; -.
DR   PaxDb; Q6IQ97; -.
DR   PRIDE; Q6IQ97; -.
DR   Ensembl; ENSDART00000052862; ENSDARP00000052861; ENSDARG00000036386.
DR   GeneID; 573001; -.
DR   KEGG; dre:573001; -.
DR   CTD; 573001; -.
DR   ZFIN; ZDB-GENE-030131-3902; rbm4.1.
DR   eggNOG; KOG0109; Eukaryota.
DR   GeneTree; ENSGT00940000164485; -.
DR   HOGENOM; CLU_045263_0_1_1; -.
DR   InParanoid; Q6IQ97; -.
DR   OMA; RYEREPY; -.
DR   OrthoDB; 1563362at2759; -.
DR   PhylomeDB; Q6IQ97; -.
DR   TreeFam; TF320661; -.
DR   Reactome; R-DRE-8941326; RUNX2 regulates bone development.
DR   PRO; PR:Q6IQ97; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000036386; Expressed in early embryo and 28 other tissues.
DR   ExpressionAtlas; Q6IQ97; baseline.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd12606; RRM1_RBM4; 1.
DR   CDD; cd12607; RRM2_RBM4; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034897; RBM4_RRM1.
DR   InterPro; IPR034898; RBM4_RRM2.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR001878; Znf_CCHC.
DR   Pfam; PF00076; RRM_1; 2.
DR   Pfam; PF00098; zf-CCHC; 1.
DR   SMART; SM00360; RRM; 2.
DR   SMART; SM00343; ZnF_C2HC; 1.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   1: Evidence at protein level;
KW   Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   RNA-binding; Zinc; Zinc-finger.
FT   CHAIN           1..419
FT                   /note="RNA-binding protein 4.1"
FT                   /id="PRO_0000081757"
FT   DOMAIN          2..72
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          78..148
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   ZN_FING         160..177
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   REGION          322..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          349..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         393
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18307296"
FT   CONFLICT        80
FT                   /note="L -> P (in Ref. 1; AAH46057)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   419 AA;  46135 MW;  4A20564BAD4242B1 CRC64;
     MVKIFVGNLS PNTTAEEIRS LFSQYGKISE CDIVKNFGFV HMDSKSEADE AIQNLHHYML
     NGMAMNVEMS KGKPKTSTKL HVGNISSSCT NQELRAKFEE YGPVVECDIV KDYAFVHMER
     VEDAMEAISG LDNTAFQGKL MSVKLSTSRL RTAPGMGERT GCYRCGQEGH WSKECPLDQN
     GSYREGPSSE GFGPVRFDSG GDRGRGFHRG FSGEPAYAGS FAPSHGFTRG AGYAVPGYGR
     GAGFESAMGY GMPAGYGVGA DNSMAPVYGS EAAYGTSGMA YPGALPAYPI RRPPYEERDP
     YGVVDFYEKY RARPYGGSYF EDRRAVQPPV PPPPTSTPVV RERLPSNLVD PYERHPLPPP
     PAPTSSYYVR ERSPVRRAPH EAEGYAYERS RLSPISVLPR TAAYDVPRDP YAERARYAY