RBM41_HUMAN
ID RBM41_HUMAN Reviewed; 413 AA.
AC Q96IZ5; Q5JSN7; Q5JSN8; Q9H8F7; Q9NV04;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=RNA-binding protein 41;
DE AltName: Full=RNA-binding motif protein 41;
GN Name=RBM41;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT TYR-376.
RC TISSUE=Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP STRUCTURE BY NMR OF 291-392.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of RNA binding domain in hypothetical protein
RT FLJ11016.";
RL Submitted (NOV-2005) to the PDB data bank.
CC -!- FUNCTION: May bind RNA. {ECO:0000305}.
CC -!- INTERACTION:
CC Q96IZ5; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-740773, EBI-11975051;
CC Q96IZ5; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-740773, EBI-10175300;
CC Q96IZ5; P24863: CCNC; NbExp=3; IntAct=EBI-740773, EBI-395261;
CC Q96IZ5; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-740773, EBI-742887;
CC Q96IZ5; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-740773, EBI-11988027;
CC Q96IZ5; Q08379: GOLGA2; NbExp=6; IntAct=EBI-740773, EBI-618309;
CC Q96IZ5; P07910: HNRNPC; NbExp=5; IntAct=EBI-740773, EBI-357966;
CC Q96IZ5; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-740773, EBI-10961706;
CC Q96IZ5; O75031: HSF2BP; NbExp=3; IntAct=EBI-740773, EBI-7116203;
CC Q96IZ5; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-740773, EBI-14069005;
CC Q96IZ5; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-740773, EBI-3044087;
CC Q96IZ5; Q6A162: KRT40; NbExp=3; IntAct=EBI-740773, EBI-10171697;
CC Q96IZ5; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-740773, EBI-741037;
CC Q96IZ5; P50221: MEOX1; NbExp=3; IntAct=EBI-740773, EBI-2864512;
CC Q96IZ5; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-740773, EBI-2548751;
CC Q96IZ5; Q13064: MKRN3; NbExp=3; IntAct=EBI-740773, EBI-2340269;
CC Q96IZ5; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-740773, EBI-11522433;
CC Q96IZ5; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-740773, EBI-10271199;
CC Q96IZ5; Q9Y2I6: NINL; NbExp=3; IntAct=EBI-740773, EBI-719716;
CC Q96IZ5; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-740773, EBI-302345;
CC Q96IZ5; Q86SE5: RALYL; NbExp=4; IntAct=EBI-740773, EBI-741520;
CC Q96IZ5; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-740773, EBI-11987469;
CC Q96IZ5; Q6NUQ1: RINT1; NbExp=6; IntAct=EBI-740773, EBI-726876;
CC Q96IZ5; Q96R06: SPAG5; NbExp=3; IntAct=EBI-740773, EBI-413317;
CC Q96IZ5; O43548: TGM5; NbExp=3; IntAct=EBI-740773, EBI-12027348;
CC Q96IZ5; Q13077: TRAF1; NbExp=3; IntAct=EBI-740773, EBI-359224;
CC Q96IZ5; Q12933: TRAF2; NbExp=6; IntAct=EBI-740773, EBI-355744;
CC Q96IZ5; P14373: TRIM27; NbExp=3; IntAct=EBI-740773, EBI-719493;
CC Q96IZ5; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-740773, EBI-2130429;
CC Q96IZ5; Q96DT7-3: ZBTB10; NbExp=3; IntAct=EBI-740773, EBI-12017160;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96IZ5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96IZ5-2; Sequence=VSP_021349;
CC Name=3;
CC IsoId=Q96IZ5-3; Sequence=VSP_021346, VSP_021347, VSP_021348;
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DR EMBL; AK001878; BAA91957.1; -; mRNA.
DR EMBL; AK023732; BAB14660.1; -; mRNA.
DR EMBL; AL390039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC006986; AAH06986.1; -; mRNA.
DR CCDS; CCDS14526.1; -. [Q96IZ5-1]
DR CCDS; CCDS55472.1; -. [Q96IZ5-2]
DR RefSeq; NP_001164551.1; NM_001171080.1. [Q96IZ5-2]
DR RefSeq; NP_060771.3; NM_018301.4. [Q96IZ5-1]
DR PDB; 2CPX; NMR; -; A=291-392.
DR PDBsum; 2CPX; -.
DR AlphaFoldDB; Q96IZ5; -.
DR SMR; Q96IZ5; -.
DR BioGRID; 120573; 42.
DR IntAct; Q96IZ5; 35.
DR MINT; Q96IZ5; -.
DR STRING; 9606.ENSP00000361557; -.
DR iPTMnet; Q96IZ5; -.
DR PhosphoSitePlus; Q96IZ5; -.
DR BioMuta; RBM41; -.
DR DMDM; 117949772; -.
DR EPD; Q96IZ5; -.
DR jPOST; Q96IZ5; -.
DR MassIVE; Q96IZ5; -.
DR MaxQB; Q96IZ5; -.
DR PaxDb; Q96IZ5; -.
DR PeptideAtlas; Q96IZ5; -.
DR PRIDE; Q96IZ5; -.
DR ProteomicsDB; 76874; -. [Q96IZ5-1]
DR ProteomicsDB; 76875; -. [Q96IZ5-2]
DR ProteomicsDB; 76876; -. [Q96IZ5-3]
DR Antibodypedia; 29287; 138 antibodies from 19 providers.
DR DNASU; 55285; -.
DR Ensembl; ENST00000372479.7; ENSP00000361557.3; ENSG00000089682.17. [Q96IZ5-1]
DR Ensembl; ENST00000372487.5; ENSP00000361565.1; ENSG00000089682.17. [Q96IZ5-2]
DR Ensembl; ENST00000495517.5; ENSP00000433251.1; ENSG00000089682.17. [Q96IZ5-3]
DR GeneID; 55285; -.
DR KEGG; hsa:55285; -.
DR UCSC; uc004emy.3; human. [Q96IZ5-1]
DR CTD; 55285; -.
DR GeneCards; RBM41; -.
DR HGNC; HGNC:25617; RBM41.
DR HPA; ENSG00000089682; Low tissue specificity.
DR neXtProt; NX_Q96IZ5; -.
DR OpenTargets; ENSG00000089682; -.
DR PharmGKB; PA145148155; -.
DR VEuPathDB; HostDB:ENSG00000089682; -.
DR eggNOG; ENOG502RIV3; Eukaryota.
DR GeneTree; ENSGT00530000063786; -.
DR HOGENOM; CLU_054957_0_0_1; -.
DR InParanoid; Q96IZ5; -.
DR OMA; QCFAPAS; -.
DR OrthoDB; 1080666at2759; -.
DR PhylomeDB; Q96IZ5; -.
DR TreeFam; TF324298; -.
DR PathwayCommons; Q96IZ5; -.
DR SignaLink; Q96IZ5; -.
DR BioGRID-ORCS; 55285; 11 hits in 711 CRISPR screens.
DR ChiTaRS; RBM41; human.
DR EvolutionaryTrace; Q96IZ5; -.
DR GenomeRNAi; 55285; -.
DR Pharos; Q96IZ5; Tdark.
DR PRO; PR:Q96IZ5; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q96IZ5; protein.
DR Bgee; ENSG00000089682; Expressed in calcaneal tendon and 192 other tissues.
DR ExpressionAtlas; Q96IZ5; baseline and differential.
DR Genevisible; Q96IZ5; HS.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IBA:GO_Central.
DR GO; GO:0097157; F:pre-mRNA intronic binding; IBA:GO_Central.
DR GO; GO:0030626; F:U12 snRNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045164; RBM41/RNPC3.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR16105; PTHR16105; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Phosphoprotein; Reference proteome;
KW RNA-binding.
FT CHAIN 1..413
FT /note="RNA-binding protein 41"
FT /id="PRO_0000256267"
FT DOMAIN 309..387
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 223..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 232
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VAR_SEQ 174
FT /note="Q -> QAYHKKTSADKYMTSMKRKIKLGTK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021346"
FT VAR_SEQ 211..287
FT /note="EPFASHSLVSATSVGDSGTAESPSLLQDKGKQAAQGKGPSLHVANVIDFSPE
FT QCWTGPKKLTQPIEFVPEDEIQRNR -> LTSFPREDFQNLSYEGTTSVLGAKWQKRTG
FT RTSTFSILLVSLLSETVFTSSAMYGIPHLLTMSLKFSTRIGKLSFTP (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021347"
FT VAR_SEQ 288..413
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021348"
FT VAR_SEQ 406..413
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_021349"
FT VARIANT 376
FT /note="H -> Y (in dbSNP:rs17850127)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_028897"
FT CONFLICT 61
FT /note="K -> E (in Ref. 1; BAB14660)"
FT /evidence="ECO:0000305"
FT STRAND 291..293
FT /evidence="ECO:0007829|PDB:2CPX"
FT STRAND 309..314
FT /evidence="ECO:0007829|PDB:2CPX"
FT HELIX 322..328
FT /evidence="ECO:0007829|PDB:2CPX"
FT HELIX 330..334
FT /evidence="ECO:0007829|PDB:2CPX"
FT STRAND 335..338
FT /evidence="ECO:0007829|PDB:2CPX"
FT STRAND 341..345
FT /evidence="ECO:0007829|PDB:2CPX"
FT STRAND 347..349
FT /evidence="ECO:0007829|PDB:2CPX"
FT STRAND 351..356
FT /evidence="ECO:0007829|PDB:2CPX"
FT HELIX 360..369
FT /evidence="ECO:0007829|PDB:2CPX"
FT STRAND 381..384
FT /evidence="ECO:0007829|PDB:2CPX"
SQ SEQUENCE 413 AA; 47100 MW; 759B1BFF358943A8 CRC64;
MKRVNSCVKS DEHVLEELET EGERQLKSLL QHQLDTSVSI EECMSKKESF APGTMYKPFG
KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS HVSGEKKTKL RATPEAIQNR
LQDIEERISE RQRILCLPQR FAKSKQLTRR EMEIEKSLFQ GADRHSFLKA LYYQDEPQKK
NKGDPMNNLE SFYQEMIMKK RLEEFQLMRG EPFASHSLVS ATSVGDSGTA ESPSLLQDKG
KQAAQGKGPS LHVANVIDFS PEQCWTGPKK LTQPIEFVPE DEIQRNRLSE EEIRKIPMFS
SYNPGEPNKV LYLKNLSPRV TERDLVSLFA RFQEKKGPPI QFRMMTGRMR GQAFITFPNK
EIAWQALHLV NGYKLHGKIL VIEFGKNKKQ RSNLQATSLI SCATGSTTEI SGS
