RBM41_MOUSE
ID RBM41_MOUSE Reviewed; 413 AA.
AC Q8JZV4; A2AG07; Q3TMC8; Q3TPC6; Q8C9Y2;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=RNA-binding protein 41;
DE AltName: Full=RNA-binding motif protein 41;
GN Name=Rbm41;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC STRAIN=C57BL/6J; TISSUE=Embryonic heart, Lung, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May bind RNA. {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8JZV4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8JZV4-2; Sequence=VSP_021350;
CC Name=3;
CC IsoId=Q8JZV4-3; Sequence=VSP_021351;
CC Name=4;
CC IsoId=Q8JZV4-4; Sequence=VSP_021352, VSP_021353, VSP_021354;
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DR EMBL; AK040213; BAC30541.1; -; mRNA.
DR EMBL; AK084514; BAC39206.1; -; mRNA.
DR EMBL; AK084629; BAC39235.1; -; mRNA.
DR EMBL; AK164496; BAE37811.1; -; mRNA.
DR EMBL; AK166005; BAE38514.1; -; mRNA.
DR EMBL; AL672270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC037024; AAH37024.1; -; mRNA.
DR CCDS; CCDS41147.1; -. [Q8JZV4-1]
DR CCDS; CCDS53204.1; -. [Q8JZV4-2]
DR CCDS; CCDS53205.1; -. [Q8JZV4-3]
DR RefSeq; NP_001165618.1; NM_001172147.1. [Q8JZV4-2]
DR RefSeq; NP_001165619.1; NM_001172148.1. [Q8JZV4-3]
DR RefSeq; NP_001277559.1; NM_001290630.1.
DR RefSeq; NP_705814.1; NM_153586.2. [Q8JZV4-1]
DR AlphaFoldDB; Q8JZV4; -.
DR SMR; Q8JZV4; -.
DR BioGRID; 231837; 2.
DR STRING; 10090.ENSMUSP00000108631; -.
DR PhosphoSitePlus; Q8JZV4; -.
DR PaxDb; Q8JZV4; -.
DR PRIDE; Q8JZV4; -.
DR ProteomicsDB; 300318; -. [Q8JZV4-1]
DR ProteomicsDB; 300319; -. [Q8JZV4-2]
DR ProteomicsDB; 300320; -. [Q8JZV4-3]
DR ProteomicsDB; 300321; -. [Q8JZV4-4]
DR Antibodypedia; 29287; 138 antibodies from 19 providers.
DR DNASU; 237073; -.
DR Ensembl; ENSMUST00000033810; ENSMUSP00000033810; ENSMUSG00000031433. [Q8JZV4-1]
DR Ensembl; ENSMUST00000087400; ENSMUSP00000084662; ENSMUSG00000031433. [Q8JZV4-3]
DR Ensembl; ENSMUST00000113007; ENSMUSP00000108631; ENSMUSG00000031433. [Q8JZV4-2]
DR GeneID; 237073; -.
DR KEGG; mmu:237073; -.
DR UCSC; uc009ukp.2; mouse. [Q8JZV4-3]
DR UCSC; uc009ukq.2; mouse. [Q8JZV4-4]
DR UCSC; uc009ukr.2; mouse. [Q8JZV4-1]
DR UCSC; uc012hpl.1; mouse. [Q8JZV4-2]
DR CTD; 55285; -.
DR MGI; MGI:2444923; Rbm41.
DR VEuPathDB; HostDB:ENSMUSG00000031433; -.
DR eggNOG; ENOG502RIV3; Eukaryota.
DR GeneTree; ENSGT00530000063786; -.
DR HOGENOM; CLU_054957_0_0_1; -.
DR InParanoid; Q8JZV4; -.
DR OMA; QCFAPAS; -.
DR OrthoDB; 1080666at2759; -.
DR PhylomeDB; Q8JZV4; -.
DR TreeFam; TF324298; -.
DR BioGRID-ORCS; 237073; 5 hits in 72 CRISPR screens.
DR PRO; PR:Q8JZV4; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8JZV4; protein.
DR Bgee; ENSMUSG00000031433; Expressed in undifferentiated genital tubercle and 203 other tissues.
DR ExpressionAtlas; Q8JZV4; baseline and differential.
DR Genevisible; Q8JZV4; MM.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IBA:GO_Central.
DR GO; GO:0097157; F:pre-mRNA intronic binding; IBA:GO_Central.
DR GO; GO:0030626; F:U12 snRNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045164; RBM41/RNPC3.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR16105; PTHR16105; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; RNA-binding.
FT CHAIN 1..413
FT /note="RNA-binding protein 41"
FT /id="PRO_0000256268"
FT DOMAIN 309..387
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 225..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..2
FT /note="MK -> MASASSVLSLRLSS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021350"
FT VAR_SEQ 310..333
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021352"
FT VAR_SEQ 359..413
FT /note="NKDIAWQALHQINGYKLYGKILVIEFAKSKKQQSAVQRSSLITSAPDGRTEI
FT NGS -> RERISRRPCYFHWEYLTIFNSVALPRMVLKTASSELFKQHELSLGF (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021351"
FT VAR_SEQ 360..362
FT /note="KDI -> RIPA (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021353"
FT VAR_SEQ 363..413
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021354"
FT CONFLICT 268
FT /note="P -> S (in Ref. 1; BAE37811)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 413 AA; 47515 MW; FC4D67969F5E28E9 CRC64;
MKRVNSCVKD EEHVLEELET EGERQLKSLL QHQLDTSVSI EECVSKKKSF APGTMYKPFG
KEAAGTMTLS QFQTLHEKDQ ETASLRELGL NETEILIWKS HVSGEKRTKL RATPEAIQKR
LEDIKERISE RQRILCLPQR FSKSKQLTRR EMEIEKSLFQ GTDRHSFLKA LYYQDEPPKK
NKGDPMNNLE HFYRETIMKK RLEEFQLLRG ESFACHSLVS AASVSGSGTA EKPSLLQDKG
KQAAQGKGPR LHVAKLIDFP TEQYWTGPKT LKQPIEFIPE DEIQRNRLSE EEIRNIPMFS
SYNPGEPNKV LYLKNLSPRV KERDLISLFA RFQEKKGPPI QFRMMTGRMR GQAFLTFPNK
DIAWQALHQI NGYKLYGKIL VIEFAKSKKQ QSAVQRSSLI TSAPDGRTEI NGS
