ID   RBM42_BOVIN             Reviewed;         448 AA.
AC   Q0P5L0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=RNA-binding protein 42;
DE   AltName: Full=RNA-binding motif protein 42;
GN   Name=RBM42;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds (via the RRM domain) to the 3'-untranslated region
CC       (UTR) of CDKN1A mRNA. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with HNRNPK. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Upon stress response, localizes with HNRNPK in cytoplasmic
CC       aggregates of stalled translational preinitiation complexes called
CC       stress granules. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM RBM42 family. {ECO:0000305}.
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DR   EMBL; BC119904; AAI19905.1; -; mRNA.
DR   RefSeq; NP_001069673.1; NM_001076205.1.
DR   AlphaFoldDB; Q0P5L0; -.
DR   SMR; Q0P5L0; -.
DR   STRING; 9913.ENSBTAP00000017884; -.
DR   PaxDb; Q0P5L0; -.
DR   PRIDE; Q0P5L0; -.
DR   GeneID; 540172; -.
DR   KEGG; bta:540172; -.
DR   CTD; 79171; -.
DR   eggNOG; KOG0226; Eukaryota.
DR   InParanoid; Q0P5L0; -.
DR   OrthoDB; 1249623at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   CDD; cd12383; RRM_RBM42; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034215; RBM42_RRM.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Methylation; Nucleus; Phosphoprotein;
KW   Reference proteome; RNA-binding.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTD8"
FT   CHAIN           2..448
FT                   /note="RNA-binding protein 42"
FT                   /id="PRO_0000307749"
FT   DOMAIN          349..427
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..448
FT                   /note="Necessary for interaction with HNRNPK"
FT                   /evidence="ECO:0000250"
FT   REGION          286..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..306
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..324
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTD8"
FT   MOD_RES         132
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTD8"
FT   MOD_RES         149
FT                   /note="Asymmetric dimethylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTD8"
SQ   SEQUENCE   448 AA;  47187 MW;  F74332BD3A707A61 CRC64;
     MAGAGPAPGL PGAGGPVVPG PGAGIPGKSG EERLKEMEAE MALFEQEVLG APVTGIPTAV
     PAVPTVPTVE AMQVPAAPVI RPIIATNTYQ QVQQTLEARA AAAATVVPPM VGGPPFVGPV
     GFGPGDRSHL DSPEAREAMF LRRAAAGPRP MALRPPHQAL VGPPLPGPPG PPMMLPPMAR
     APGPPLGSMA ALRPPLEEPA TPRELGLGLG LGLKEKEEAV VAAAAGLEEA SAVVAVGAGG
     APAGPAVIGP SLPLALAMPL PEPEPLPLPL EVVRGLLPPL RIPELLSLRP RPRPPRPEPP
     PGLMALEVPE PLSEDKKKGK PEKLKRCIRT AAGSSWEDPS LLEWDADDFR IFCGDLGNEV
     NDDILARAFS RFPSFLKAKV IRDKRTGKTK GYGFVSFKDP SDYVRAMREM NGKYVGSRPI
     KLRKSMWKDR NLDVVRKKQK EKKKLGLR