ID   RBM42_DANRE             Reviewed;         402 AA.
AC   Q6DRG1; Q504F4;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=RNA-binding protein 42;
DE   AltName: Full=RNA-binding motif protein 42;
GN   Name=rbm42;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA   Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA   Hopkins N.;
RT   "Identification of 315 genes essential for early zebrafish development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May bind RNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM RBM42 family. {ECO:0000305}.
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DR   EMBL; AY648798; AAT68116.1; -; mRNA.
DR   EMBL; BC095046; AAH95046.1; -; mRNA.
DR   RefSeq; NP_001003850.1; NM_001003850.1.
DR   AlphaFoldDB; Q6DRG1; -.
DR   SMR; Q6DRG1; -.
DR   STRING; 7955.ENSDARP00000058379; -.
DR   PaxDb; Q6DRG1; -.
DR   PRIDE; Q6DRG1; -.
DR   GeneID; 445360; -.
DR   KEGG; dre:445360; -.
DR   CTD; 79171; -.
DR   ZFIN; ZDB-GENE-040809-2; rbm42.
DR   eggNOG; KOG0226; Eukaryota.
DR   InParanoid; Q6DRG1; -.
DR   OrthoDB; 1249623at2759; -.
DR   PhylomeDB; Q6DRG1; -.
DR   TreeFam; TF313946; -.
DR   PRO; PR:Q6DRG1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0002088; P:lens development in camera-type eye; IMP:ZFIN.
DR   CDD; cd12383; RRM_RBM42; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034215; RBM42_RRM.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..402
FT                   /note="RNA-binding protein 42"
FT                   /id="PRO_0000307753"
FT   DOMAIN          303..381
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          240..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        261..275
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        91
FT                   /note="Q -> P (in Ref. 1; AAT68116)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        236
FT                   /note="D -> E (in Ref. 1; AAT68116)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        380
FT                   /note="A -> T (in Ref. 1; AAT68116)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        392
FT                   /note="N -> K (in Ref. 1; AAT68116)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   402 AA;  43690 MW;  2E97DE2976418D5B CRC64;
     MALKSGEERL KEMEAEMALF EQEVLGGPVA PTVVEAVPVA LAMPTLPMVR PIIGTNTYRE
     VQQSLEARAA TLVGPPPTFV CPAIPAVPPP QVLRPAFVPH VLQRPAGGHR MPMMRGPPPH
     GMIAPPLPRP PPPPPSMMAP PVVGPPQPPM APVGPPMGPM PPVGGMNPMA LGPPRSMTQA
     PAKITPSVIQ AAPTVYTAPP VSKRIDLKSQ KQARMEQLSA LVAEQQAAVL AAGLLDSKKE
     TASDDSVIGP SMPEPEPVHV EPVDTSTEDK KKGKQEKVKK CIRVAAGVSW EDTSLLEWET
     DDFRIFCGDL GNEVNDDILA RAFSRYPSFL KAKVVRDKRT GKTKGYGFVS FKDPNDYVRA
     MREMNGRYVG SRPIKLRKSA WKDRNLEVVR KNQKEKKKLG LR