RBM43_HUMAN
ID RBM43_HUMAN Reviewed; 357 AA.
AC Q6ZSC3; B2RMT5;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=RNA-binding protein 43;
DE AltName: Full=RNA-binding motif protein 43;
GN Name=RBM43; Synonyms=C2orf38;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6ZSC3; Q15038: DAZAP2; NbExp=3; IntAct=EBI-2880658, EBI-724310;
CC Q6ZSC3; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-2880658, EBI-11522367;
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DR EMBL; AK127552; BAC87031.1; -; mRNA.
DR EMBL; CH471058; EAX11514.1; -; Genomic_DNA.
DR EMBL; BC136410; AAI36411.1; -; mRNA.
DR EMBL; BC136411; AAI36412.1; -; mRNA.
DR CCDS; CCDS2191.1; -.
DR RefSeq; NP_940959.1; NM_198557.2.
DR AlphaFoldDB; Q6ZSC3; -.
DR SMR; Q6ZSC3; -.
DR BioGRID; 131966; 9.
DR IntAct; Q6ZSC3; 3.
DR STRING; 9606.ENSP00000331211; -.
DR iPTMnet; Q6ZSC3; -.
DR PhosphoSitePlus; Q6ZSC3; -.
DR BioMuta; RBM43; -.
DR DMDM; 74711383; -.
DR EPD; Q6ZSC3; -.
DR jPOST; Q6ZSC3; -.
DR MassIVE; Q6ZSC3; -.
DR PaxDb; Q6ZSC3; -.
DR PeptideAtlas; Q6ZSC3; -.
DR PRIDE; Q6ZSC3; -.
DR ProteomicsDB; 68214; -.
DR Antibodypedia; 51960; 79 antibodies from 16 providers.
DR DNASU; 375287; -.
DR Ensembl; ENST00000331426.6; ENSP00000331211.5; ENSG00000184898.7.
DR GeneID; 375287; -.
DR KEGG; hsa:375287; -.
DR MANE-Select; ENST00000331426.6; ENSP00000331211.5; NM_198557.3; NP_940959.1.
DR UCSC; uc002txh.4; human.
DR CTD; 375287; -.
DR DisGeNET; 375287; -.
DR GeneCards; RBM43; -.
DR HGNC; HGNC:24790; RBM43.
DR HPA; ENSG00000184898; Low tissue specificity.
DR neXtProt; NX_Q6ZSC3; -.
DR OpenTargets; ENSG00000184898; -.
DR PharmGKB; PA162400761; -.
DR VEuPathDB; HostDB:ENSG00000184898; -.
DR eggNOG; KOG4012; Eukaryota.
DR GeneTree; ENSGT00530000063686; -.
DR HOGENOM; CLU_067477_0_0_1; -.
DR InParanoid; Q6ZSC3; -.
DR OMA; TTICLKN; -.
DR OrthoDB; 1476205at2759; -.
DR PhylomeDB; Q6ZSC3; -.
DR TreeFam; TF335737; -.
DR PathwayCommons; Q6ZSC3; -.
DR SignaLink; Q6ZSC3; -.
DR BioGRID-ORCS; 375287; 15 hits in 1073 CRISPR screens.
DR GenomeRNAi; 375287; -.
DR Pharos; Q6ZSC3; Tdark.
DR PRO; PR:Q6ZSC3; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q6ZSC3; protein.
DR Bgee; ENSG00000184898; Expressed in oviduct epithelium and 152 other tissues.
DR ExpressionAtlas; Q6ZSC3; baseline and differential.
DR Genevisible; Q6ZSC3; HS.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034463; RBM43.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR15225:SF8; PTHR15225:SF8; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW Reference proteome; RNA-binding.
FT CHAIN 1..357
FT /note="RNA-binding protein 43"
FT /id="PRO_0000264247"
FT DOMAIN 15..104
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT VARIANT 259
FT /note="I -> V (in dbSNP:rs35749426)"
FT /id="VAR_033722"
SQ SEQUENCE 357 AA; 40666 MW; D0EEA2B465888036 CRC64;
MASVLNVKES KAPERTVVVA GLPVDLFSDQ LLAVLVKSHF QDIKNEGGDV EDVIYPTRTK
GVAYVIFKEK KVAENVIRQK KHWLARKTRH AELTVSLRVS HFGDKIFSSV NAILDLSVFG
KEVTLETLVK DLKKKIPSLS FSPLKPNGRI SVEGSFLAVK RLRESLLARA CSLLEKDRNF
TSEERKWNRQ NPQRNLQRSN NSLASVRTLV PETARSGEML VLDTDVFLYL KHKCGSYEST
LKKFHILSQE KVDGEITTIC LKSIQVGSQP NNAKHVKELI EEWSHALYLK LRKETFILEG
KENREKRMIK RACEQLSSRY LEVLINLYRT HIDIIGSSSD TYLFKKGVMK LIGQKVS
