RBM44_DANRE
ID RBM44_DANRE Reviewed; 956 AA.
AC B0S6S9;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=RNA-binding protein 44;
DE AltName: Full=RNA-binding motif protein 44;
GN Name=rbm44; ORFNames=si:dkey-189g17.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: Component of intercellular bridges during meiosis.
CC Intercellular bridges are evolutionarily conserved structures that
CC connect differentiating germ cells. Not required for fertility (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Detected in the
CC intercellular bridges. {ECO:0000250}.
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DR EMBL; CR391951; CAQ13988.1; -; Genomic_DNA.
DR EMBL; BX548053; CAQ13988.1; JOINED; Genomic_DNA.
DR EMBL; BX548053; CAQ14813.1; -; Genomic_DNA.
DR EMBL; CR391951; CAQ14813.1; JOINED; Genomic_DNA.
DR RefSeq; NP_001122014.1; NM_001128542.1.
DR AlphaFoldDB; B0S6S9; -.
DR SMR; B0S6S9; -.
DR STRING; 7955.ENSDARP00000092541; -.
DR PaxDb; B0S6S9; -.
DR PeptideAtlas; B0S6S9; -.
DR Ensembl; ENSDART00000101765; ENSDARP00000092541; ENSDARG00000069758.
DR GeneID; 567482; -.
DR KEGG; dre:567482; -.
DR CTD; 375316; -.
DR ZFIN; ZDB-GENE-030131-5562; rbm44.
DR eggNOG; ENOG502S2NU; Eukaryota.
DR GeneTree; ENSGT00940000173784; -.
DR HOGENOM; CLU_308577_0_0_1; -.
DR InParanoid; B0S6S9; -.
DR OMA; CQQHCWR; -.
DR OrthoDB; 146487at2759; -.
DR PhylomeDB; B0S6S9; -.
DR PRO; PR:B0S6S9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000069758; Expressed in testis and 14 other tissues.
DR ExpressionAtlas; B0S6S9; baseline.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0045171; C:intercellular bridge; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; RNA-binding.
FT CHAIN 1..956
FT /note="RNA-binding protein 44"
FT /id="PRO_0000417525"
FT DOMAIN 750..824
FT /note="RRM"
FT REGION 301..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..852
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 956 AA; 106589 MW; 360B7EC2FD28639D CRC64;
MWYPPAAVVP FFESHSVTYE DRSAIAKWHF LPFDQRAVNE MTVLLNFLHI SQGFHNETLY
TDVRRRCMLM RSLFELVFAN NYLELTNPKL LGWFLYLTAE DRTLIQNEGG LLSFLKKHPE
LGVTRQYVYV KAKPKGNYVP PPTTMASNDS RYPTFYGSSG CQNCGTSCPF GTKKCTRCGV
HIVISQDKIS VSENEKQLQL LPNSLKEELN VFQTSQSNVE MQNIHLGCTQ STLNTRSKQR
SPEAHPHFYS KGMCSHAQCL SQLWQEVESR EDAKHFKDTS AQASFCLDME LDVQSQVQRN
DNTQNNQNQS YNPTEENDHN VDQETMPEYY SFSSISLDHT AWSNGSQSAE TGFNDSITAT
KGSTELSDEL SEAANSTAAN STDCFSCVSN SFELAEESGD CLDSRYEQQI NKSNVGSSPK
SKSSASVYVD QMIDACGDFR AFFTSTCATK TDQTFQVKNV ATDTDLPAVS HEKDTQTMRM
TTSDKNTITE VYMSDLDVLT EEFIKLKETE KGLKQMKSMN ARRLCGCDCA QRVRKAELNL
LALQFVMCQQ HCWRRYFTSP LGESAYQGTE ALPDSIAETL KTLQKDYHEM RQQILAGTPL
DDLAPLSVNS EKISTGTNYS PSSVLAAHLD CAGSTIASDH KVDEEHTAMK VPPSEVCQDI
ETAPDEAKNE CSKRDKALFI LPKQTRISTE PKTVGANKDL NGSEAWFDAE EELGFPNQDG
NMEKPNKMRE TMRHKMETKG TDEDVSKQSS LLCITCLPGN ITEHEVLLWF EKYNPTNVCI
SAFSNNTRAA IVYLKSYIDA KAAVEDLNGR SLQGHAVQVV HLSGTVSADL KPSDLSHSAS
ESHKEDTAGD ELRTKNLTYG SSHGGPRCSL ERLTNVCNSP TASGTCVPQH YATMGSFDTI
MARLSERHPN VARQRIVDAL LELRAKHQGF LSGLPLRSIV DMTSELLTQT SSSARV
