RBM44_HUMAN
ID RBM44_HUMAN Reviewed; 1051 AA.
AC Q6ZP01; A0A0A0MR46; A0AUW3;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-MAY-2022, sequence version 4.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=RNA-binding protein 44;
DE AltName: Full=RNA-binding motif protein 44;
GN Name=RBM44;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-1051.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 810-1051.
RC TISSUE=Prostate;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: Component of intercellular bridges during meiosis.
CC Intercellular bridges are evolutionarily conserved structures that
CC connect differentiating germ cells. Not required for fertility (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Interacts with TEX14 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Detected in the
CC intercellular bridges. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI26112.1; Type=Miscellaneous discrepancy; Note=Unlikely splicing event.; Evidence={ECO:0000305};
CC Sequence=BAC85324.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC012076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126111; AAI26112.1; ALT_SEQ; mRNA.
DR EMBL; AK130316; BAC85324.1; ALT_INIT; mRNA.
DR RefSeq; NP_001073973.2; NM_001080504.2.
DR RefSeq; XP_011509457.1; XM_011511155.1.
DR AlphaFoldDB; Q6ZP01; -.
DR SMR; Q6ZP01; -.
DR BioGRID; 131970; 2.
DR IntAct; Q6ZP01; 2.
DR STRING; 9606.ENSP00000321179; -.
DR GlyConnect; 2071; 1 N-Linked glycan (1 site).
DR GlyGen; Q6ZP01; 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site).
DR iPTMnet; Q6ZP01; -.
DR PhosphoSitePlus; Q6ZP01; -.
DR BioMuta; RBM44; -.
DR DMDM; 152060496; -.
DR EPD; Q6ZP01; -.
DR jPOST; Q6ZP01; -.
DR MassIVE; Q6ZP01; -.
DR MaxQB; Q6ZP01; -.
DR PaxDb; Q6ZP01; -.
DR PeptideAtlas; Q6ZP01; -.
DR PRIDE; Q6ZP01; -.
DR ProteomicsDB; 68051; -.
DR Antibodypedia; 1145; 8 antibodies from 7 providers.
DR DNASU; 375316; -.
DR Ensembl; ENST00000316997.9; ENSP00000321179.5; ENSG00000177483.12.
DR Ensembl; ENST00000409864.6; ENSP00000386727.2; ENSG00000177483.12.
DR GeneID; 375316; -.
DR KEGG; hsa:375316; -.
DR MANE-Select; ENST00000316997.9; ENSP00000321179.5; NM_001080504.3; NP_001073973.3.
DR UCSC; uc002vxi.5; human.
DR UCSC; uc061ubp.1; human.
DR CTD; 375316; -.
DR GeneCards; RBM44; -.
DR HGNC; HGNC:24756; RBM44.
DR HPA; ENSG00000177483; Tissue enriched (testis).
DR neXtProt; NX_Q6ZP01; -.
DR OpenTargets; ENSG00000177483; -.
DR PharmGKB; PA162400774; -.
DR VEuPathDB; HostDB:ENSG00000177483; -.
DR eggNOG; ENOG502S2NU; Eukaryota.
DR GeneTree; ENSGT00390000016508; -.
DR HOGENOM; CLU_657140_0_0_1; -.
DR InParanoid; Q6ZP01; -.
DR OMA; EVRINHK; -.
DR OrthoDB; 99726at2759; -.
DR PhylomeDB; Q6ZP01; -.
DR TreeFam; TF337508; -.
DR PathwayCommons; Q6ZP01; -.
DR SignaLink; Q6ZP01; -.
DR BioGRID-ORCS; 375316; 28 hits in 1072 CRISPR screens.
DR ChiTaRS; RBM44; human.
DR GenomeRNAi; 375316; -.
DR Pharos; Q6ZP01; Tdark.
DR PRO; PR:Q6ZP01; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q6ZP01; protein.
DR Bgee; ENSG00000177483; Expressed in right testis and 93 other tissues.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0045171; C:intercellular bridge; ISS:UniProtKB.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd12248; RRM_RBM44; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034153; RBM44_RRM.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Phosphoprotein; Reference proteome; RNA-binding.
FT CHAIN 1..1051
FT /note="RNA-binding protein 44"
FT /id="PRO_0000294174"
FT DOMAIN 830..903
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 388
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3V089"
FT MOD_RES 391
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3V089"
FT MOD_RES 546
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3V089"
FT MOD_RES 726
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3V089"
FT VARIANT 51
FT /note="D -> H (in dbSNP:rs13393001)"
FT /id="VAR_057247"
FT VARIANT 52
FT /note="D -> H (in dbSNP:rs13393001)"
FT /id="VAR_033147"
FT VARIANT 892
FT /note="N -> H (in dbSNP:rs10186505)"
FT /id="VAR_033148"
SQ SEQUENCE 1051 AA; 117985 MW; 45400796EEAF1415 CRC64;
MQATAVVETA SGKGYHSNGG NLQKDKPSNP KKENLLLSSN GCDEVKLTFP DDDWNSSTLE
QRANNKEISN IDKMDLLEPF FSVSQDTNTE STQFQSSELE DSTDYAFLNK TYSIPYSESK
LKKESLTPLS SELDPEVQKK EEVFFNILEH QDKTVGLERI YNISDANYRE SAEDTQKHDT
DEDSQQEYHS AEEQEYISNH LSFDQTKALD ISNPEVVELG NSGYEVKCAS NVEDNRVNSG
SGSIISFDSL DVYGQEESLH VSKFQNSVML REYHDLKHEK YKEQETNSMY HTVFDGSVLR
SNSPGNQESQ SKSGSLSPQK VLKMKIYTEN MKSQINEGKD FCGNKIVENK ILLHLENPST
LPQDKALETL LQPCKDCQTS WTSVFDDSII SACGYYESLQ NTADSALDFS AMLPKIAVRD
NQAIEDNTSL KVAHSSTTKK TCFHNIGEMC TKSLTDAASC TVTINQTVDV STDFRACFTT
SRATSARPSV VSTSSNTEIT MMNKKRPDEW QNEKQKSVAC STDWSYSEDC IDTQMAITKG
SGKSLSVDSL KPNGNFLNKD FLELRKACGI TDLKKHPERE FQLFKDTEKD LPSMCCQKIM
QRAIKAELHL LNVHYQMCRR HCCDIYKLVM ENREGLNMNL SSNSAKKELG SALLSLLGDL
KVRYVTLKEK IHKGIPLEEL PPLSLESKLL STFSTFASRL MKKETHVFSE ADAEQDNQRA
HDVDVSSNLK KTLSQMSLSS DNSHATQNIS PKKDDFKNGD INADFSQLKL GDKDCRHYQE
TSEDWSDAKE SLTGVDVSGT QGNQVEQDTW NLDLTGEMKN VEPSQRDKGY LIHVGGLCPS
VSEADLRSHF QKYQVSEISI YDSTNYRYAS LAFTKNSDAK IAVKEMNGIE INGKSVNVWP
VKILGEYTSP LSSKNGNRIS SNNLEKSTNK QIHSEFSISR LPRTRPRQLG SEQDSEVFPS
DQGVKKNCKQ IESAKLLPDT PVQFIPPNTL NLRSFTKIIK RLAELHPEVS RDHIINALQE
VRIRHKGFLN GLSITTIVEM TSSLLKNSAS S
