ID   RBM46_MOUSE             Reviewed;         533 AA.
AC   P86049;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Probable RNA-binding protein 46;
DE   AltName: Full=RNA-binding motif protein 46 {ECO:0000312|MGI:MGI:3645057};
GN   Name=Rbm46 {ECO:0000312|MGI:MGI:3645057};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
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DR   EMBL; AC158935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS50938.1; -.
DR   RefSeq; NP_001139800.1; NM_001146328.2.
DR   RefSeq; XP_006501913.1; XM_006501850.3.
DR   RefSeq; XP_006501914.1; XM_006501851.1.
DR   RefSeq; XP_011238490.1; XM_011240188.1.
DR   AlphaFoldDB; P86049; -.
DR   SMR; P86049; -.
DR   STRING; 10090.ENSMUSP00000045511; -.
DR   iPTMnet; P86049; -.
DR   PhosphoSitePlus; P86049; -.
DR   EPD; P86049; -.
DR   jPOST; P86049; -.
DR   PaxDb; P86049; -.
DR   PeptideAtlas; P86049; -.
DR   PRIDE; P86049; -.
DR   ProteomicsDB; 255003; -.
DR   Antibodypedia; 16839; 106 antibodies from 20 providers.
DR   Ensembl; ENSMUST00000048647; ENSMUSP00000045511; ENSMUSG00000033882.
DR   GeneID; 633285; -.
DR   KEGG; mmu:633285; -.
DR   CTD; 166863; -.
DR   MGI; MGI:3645057; Rbm46.
DR   VEuPathDB; HostDB:ENSMUSG00000033882; -.
DR   eggNOG; KOG0117; Eukaryota.
DR   GeneTree; ENSGT00940000155927; -.
DR   InParanoid; P86049; -.
DR   OMA; QSYFMPE; -.
DR   OrthoDB; 1384330at2759; -.
DR   PhylomeDB; P86049; -.
DR   TreeFam; TF314932; -.
DR   BioGRID-ORCS; 633285; 4 hits in 57 CRISPR screens.
DR   PRO; PR:P86049; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; P86049; protein.
DR   Bgee; ENSMUSG00000033882; Expressed in spermatocyte and 109 other tissues.
DR   ExpressionAtlas; P86049; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IDA:MGI.
DR   GO; GO:0048255; P:mRNA stabilization; IDA:MGI.
DR   GO; GO:0001829; P:trophectodermal cell differentiation; IMP:MGI.
DR   CDD; cd19901; DSRM_RBM46; 1.
DR   CDD; cd12484; RRM1_RBM46; 1.
DR   CDD; cd12492; RRM2_RBM46; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR006535; HnRNP_R/Q_splicing_fac.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR044462; RBM46_DSR.
DR   InterPro; IPR034434; RBM46_RRM1.
DR   InterPro; IPR034435; RBM46_RRM2.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 3.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   TIGRFAMs; TIGR01648; hnRNP-R-Q; 1.
DR   PROSITE; PS50102; RRM; 3.
PE   1: Evidence at protein level;
KW   Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..533
FT                   /note="Probable RNA-binding protein 46"
FT                   /id="PRO_0000355073"
FT   DOMAIN          61..139
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          141..223
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          236..308
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          338..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   533 AA;  60077 MW;  9C206D1DE2D027D7 CRC64;
     MNEENTDGTN GCSKVRTGTQ NEAALLALME KTGYNMVQEN GQRKFGGPPP GWEGPPPPRG
     CEVFVGKIPR DMYEDELVPV FERAGKIYEF RLMMEFSGEN RGYAFVMYTT KEEAQLAIRI
     LNNYEIRPGK FIGVCVSLDN CRLFIGAIPK EKKKEEILDE MKKVTEGVVD VIVYPSATDK
     TKNRGFAFVE YESHRAAAMA RRKLIPGTFQ LWGHTIQVDW ADPEKEVDEE TMQRVKVLYV
     RNLMISTTEE TIKAEFSKFK PGAVERVKKL RDYAFVHFFH REDAVAAMSV MNGKCIDGAS
     IEVTLAKPVN KENTWRQHLN GQISPNSENL LVYANKEESH SKSLGKPPTL PTRLNGQHSP
     SPPEIERCTY PFFPGTKLTP ISMYSLKSNH FNSAVMHLDY YCNKNNWAPP EYYLYSTTSQ
     DGKVLLVYKI VIPAIANGSQ SYFMPDKLCT TLEDAKELAA QFTLLHLDFN FRRSSINSLS
     PVSTTLSSGT PSMLPYTSRP SSYPSYPLSP TISLANGSHV GQRLYISNQA SFF