ID   RBM47_PONAB             Reviewed;         593 AA.
AC   Q5R5P4; Q5RBZ7; Q5RD47;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=RNA-binding protein 47;
DE   AltName: Full=RNA-binding motif protein 47;
GN   Name=RBM47;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5R5P4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5R5P4-2; Sequence=VSP_028842;
CC   -!- SIMILARITY: Belongs to the RRM RBM47 family. {ECO:0000305}.
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DR   EMBL; CR858071; CAH90310.1; -; mRNA.
DR   EMBL; CR858485; CAH90713.1; -; mRNA.
DR   EMBL; CR860813; CAH92922.1; -; mRNA.
DR   RefSeq; NP_001127604.1; NM_001134132.1.
DR   RefSeq; NP_001128783.1; NM_001135311.1.
DR   AlphaFoldDB; Q5R5P4; -.
DR   SMR; Q5R5P4; -.
DR   GeneID; 100174683; -.
DR   GeneID; 100189684; -.
DR   KEGG; pon:100174683; -.
DR   CTD; 54502; -.
DR   InParanoid; Q5R5P4; -.
DR   OrthoDB; 1384330at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016554; P:cytidine to uridine editing; IEA:InterPro.
DR   CDD; cd12491; RRM2_RBM47; 1.
DR   CDD; cd12497; RRM3_RBM47; 1.
DR   Gene3D; 3.30.70.330; -; 3.
DR   InterPro; IPR006535; HnRNP_R/Q_splicing_fac.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034442; RBM47.
DR   InterPro; IPR034440; RBM47_RRM2.
DR   InterPro; IPR034445; RBM47_RRM3.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR21245:SF6; PTHR21245:SF6; 1.
DR   Pfam; PF00076; RRM_1; 3.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; SSF54928; 3.
DR   TIGRFAMs; TIGR01648; hnRNP-R-Q; 1.
DR   PROSITE; PS50102; RRM; 3.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Methylation; Nucleus; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..593
FT                   /note="RNA-binding protein 47"
FT                   /id="PRO_0000307857"
FT   DOMAIN          71..149
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          151..233
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          246..318
FT                   /note="RRM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         332
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:A0AV96"
FT   MOD_RES         394
FT                   /note="Asymmetric dimethylarginine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:A0AV96"
FT   MOD_RES         394
FT                   /note="Omega-N-methylarginine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:A0AV96"
FT   MOD_RES         405
FT                   /note="Asymmetric dimethylarginine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:A0AV96"
FT   MOD_RES         405
FT                   /note="Omega-N-methylarginine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:A0AV96"
FT   VAR_SEQ         53..95
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_028842"
FT   CONFLICT        11
FT                   /note="S -> G (in Ref. 1; CAH90310)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13
FT                   /note="S -> G (in Ref. 1; CAH90310)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        144
FT                   /note="V -> A (in Ref. 1; CAH90713)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        186
FT                   /note="S -> G (in Ref. 1; CAH90310)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        439
FT                   /note="I -> T (in Ref. 1; CAH90713)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        478
FT                   /note="S -> G (in Ref. 1; CAH90713)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        590
FT                   /note="Y -> C (in Ref. 1; CAH90310)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   593 AA;  64051 MW;  C21A4A40048DF316 CRC64;
     MTAEDSIAAM SSSSAAGSSA KVPEGVAGAP NEAALLALME RTGYSMVQEN GQRKYGGPPP
     GWEGPHPQRG CEVFVGKIPR DVYEDELVPV FEAVGRIYEL RLMMDFDGKN RGYAFVMYCH
     KHEAKRAVRE LNNYEIRPGR LLGVCCSVDN CRLFIGGIPK MKKREEILEE IAKVTEGVLD
     VIVYASAADK MKNRGFAFVE YESHRAAAMA RRKLMPGRIQ LWGHQIAVDW AEPEIDVDED
     VMETVKILYV RNLMIETTED TIKKSFGQFN PGCVERVKKI RDYAFVHFTS REDAVHAMNN
     LNGTELEGSC LEVTLAKPVD KEQYSRYQKA ARGGGAAEAA QQPSYVYSCD PYTLAYYGYP
     YNALIGPNRD YFVKAGSIRG RGRGAAGNRA PGPRGSYLGG YSAGRGIYSR YHEGKGKQQE
     KGYELVPNLE IPTVNPVAIK PGTVAIPAIG AQYSMFPAAP APKMIEDGKI HTVEHMISPI
     AVQPDPASAA AAAAAAAAAA AAVIPTVSTP PPFQGRPITP VYTVAPNVQR IPTAGIYGAS
     YVPFAAPATA TIATLQKNAA AAAAVYGGYA GYIPQAFPAA AIQVPIPDVY QTY