RBM48_DANRE
ID RBM48_DANRE Reviewed; 364 AA.
AC A4FVJ7; Q1LWY9; Q58EL1; Q6TEL8;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=RNA-binding protein 48;
GN Name=rbm48; ORFNames=si:ch211-173p18.5;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney marrow;
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the RBM48 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ98007.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY423031; AAQ98007.1; ALT_FRAME; mRNA.
DR EMBL; BX510986; CAK04237.1; -; Genomic_DNA.
DR EMBL; BC091857; AAH91857.1; -; mRNA.
DR EMBL; BC134007; AAI34008.1; -; mRNA.
DR AlphaFoldDB; A4FVJ7; -.
DR SMR; A4FVJ7; -.
DR STRING; 7955.ENSDARP00000049146; -.
DR PaxDb; A4FVJ7; -.
DR PRIDE; A4FVJ7; -.
DR ZFIN; ZDB-GENE-060328-1; rbm48.
DR eggNOG; ENOG502QSNB; Eukaryota.
DR InParanoid; A4FVJ7; -.
DR PhylomeDB; A4FVJ7; -.
DR TreeFam; TF328457; -.
DR PRO; PR:A4FVJ7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd12442; RRM_RBM48; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR039599; RBM48.
DR InterPro; IPR034264; RBM48_RRM.
DR PANTHER; PTHR20957; PTHR20957; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; RNA-binding.
FT CHAIN 1..364
FT /note="RNA-binding protein 48"
FT /id="PRO_0000360426"
FT DOMAIN 51..129
FT /note="RRM"
FT REGION 157..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 90
FT /note="Q -> E (in Ref. 2; CAK04237)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="Q -> R (in Ref. 2; CAK04237)"
FT /evidence="ECO:0000305"
FT CONFLICT 156
FT /note="K -> Q (in Ref. 2; CAK04237)"
FT /evidence="ECO:0000305"
FT CONFLICT 181
FT /note="I -> K (in Ref. 1; AAQ98007 and 2; CAK04237)"
FT /evidence="ECO:0000305"
FT CONFLICT 230
FT /note="K -> N (in Ref. 1; AAQ98007 and 2; CAK04237)"
FT /evidence="ECO:0000305"
FT CONFLICT 352
FT /note="Q -> L (in Ref. 2; CAK04237)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 364 AA; 41557 MW; 5F6279EEBB11E5EF CRC64;
MDGSVASSSV WDTQKVYKHH EQQNVAQTRP KYREGRRLKA VKVYTINLES RYLLVQGVPA
IGVMAELVQL FALYGVIEEY RPLDEYPAEQ FTEVYLIQFQ KLTSARAAKR HTDEKSFFGG
QLHVCYAPEY ETVEETKQKL QDRRRYVNWA SQNAAKLHSQ QAEVNTESSS STDTRTAEAP
IMQKNPEEAR RENVNSDYMG FPLLPLPPTA DISYRLQNHF TQPSQLQWTK ETTEDKMGSL
HNFIPPVQKT STQSESSSSS GVKEGDLRQK QKISTPSIRF MPRTTHLESR KRKLDEQTFF
LKEADKTGVL IGPKLPELPK LDMEDSSLNV TANLIRNTMT KAASVPEAKP VQAKHTTPKP
RRRI
