RBM48_MOUSE
ID RBM48_MOUSE Reviewed; 371 AA.
AC Q8K2X2; Q8BQM1; Q8C9L5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=RNA-binding protein 48;
GN Name=Rbm48;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Corpus striatum, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K2X2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K2X2-2; Sequence=VSP_031785;
CC -!- SIMILARITY: Belongs to the RBM48 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK041876; BAC31089.1; -; mRNA.
DR EMBL; AK047811; BAC33161.1; -; mRNA.
DR EMBL; BC029549; AAH29549.1; -; mRNA.
DR RefSeq; NP_766579.3; NM_172991.4.
DR AlphaFoldDB; Q8K2X2; -.
DR SMR; Q8K2X2; -.
DR STRING; 10090.ENSMUSP00000040952; -.
DR iPTMnet; Q8K2X2; -.
DR PhosphoSitePlus; Q8K2X2; -.
DR EPD; Q8K2X2; -.
DR MaxQB; Q8K2X2; -.
DR PaxDb; Q8K2X2; -.
DR PRIDE; Q8K2X2; -.
DR ProteomicsDB; 255004; -. [Q8K2X2-1]
DR DNASU; 269623; -.
DR GeneID; 269623; -.
DR KEGG; mmu:269623; -.
DR CTD; 84060; -.
DR MGI; MGI:2442653; Rbm48.
DR eggNOG; ENOG502QSNB; Eukaryota.
DR InParanoid; Q8K2X2; -.
DR OrthoDB; 1117000at2759; -.
DR PhylomeDB; Q8K2X2; -.
DR BioGRID-ORCS; 269623; 22 hits in 71 CRISPR screens.
DR ChiTaRS; Rbm48; mouse.
DR PRO; PR:Q8K2X2; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8K2X2; protein.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd12442; RRM_RBM48; 1.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR039599; RBM48.
DR InterPro; IPR034264; RBM48_RRM.
DR PANTHER; PTHR20957; PTHR20957; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; RNA-binding.
FT CHAIN 1..371
FT /note="RNA-binding protein 48"
FT /id="PRO_0000321515"
FT DOMAIN 46..124
FT /note="RRM"
FT REGION 157..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 102..371
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031785"
FT CONFLICT 240
FT /note="R -> K (in Ref. 1; BAC31089)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 371 AA; 41633 MW; 3421B35E4770F158 CRC64;
MASSDGKPGG VFDHHVQTAV CDSRAKYREG RRPRAVKVYT INLESQYLLI QGVPAVGAMK
ELVERFALYG AIEQYNALDE YPAEDFTEVY LIKFVKLQSA RVAKKKMDEQ SFFGGLLHVC
YAPEFETVEE TRKKLQERKA YITRVTKNQD CYMAKKKPVP EQKGTKDSRQ GFHPPMPGFG
TAALNTSPES PPENSSSCLP YSCEFPLSCF ASKSTCSRGE HVDRVSDSCN SARNHGELSR
HRDHSAFSPK LQMNTYKNSV PCSSVQEAIA TSQAVGRFMP RTTQLQERKR RRDCDRELGT
LLETHTSSNE VLIGPKLPGI PTVDLQDDSL NTTATLIRRK LKEVISSVPK PPEDNIKDVC
TSHPGKQRRR I
