RBM4B_MOUSE
ID RBM4B_MOUSE Reviewed; 357 AA.
AC Q8VE92;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=RNA-binding protein 4B;
DE AltName: Full=RNA-binding motif protein 30;
DE AltName: Full=RNA-binding motif protein 4B;
DE AltName: Full=RNA-binding protein 30;
GN Name=Rbm4b; Synonyms=Rbm30;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP FUNCTION, INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=17264215; DOI=10.1073/pnas.0607567104;
RA Kojima S., Matsumoto K., Hirose M., Shimada M., Nagano M., Shigeyoshi Y.,
RA Hoshino S., Ui-Tei K., Saigo K., Green C.B., Sakaki Y., Tei H.;
RT "LARK activates posttranscriptional expression of an essential mammalian
RT clock protein, PERIOD1.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1859-1864(2007).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for the translational activation of PER1 mRNA in
CC response to circadian clock. Binds directly to the 3'-UTR of the PER1
CC mRNA. {ECO:0000269|PubMed:17264215}.
CC -!- SUBUNIT: Interacts with TNPO3, which may mediate nuclear import of the
CC protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the suprachiasmatic nucleus (SCN) (at
CC protein level). Expressed in the suprachiasmatic nucleus (SCN).
CC {ECO:0000269|PubMed:17264215}.
CC -!- INDUCTION: Accumulates according to a circadian rhythm in the SCN.
CC {ECO:0000269|PubMed:17264215}.
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DR EMBL; BC019488; AAH19488.1; -; mRNA.
DR CCDS; CCDS29435.1; -.
DR RefSeq; NP_079993.2; NM_025717.3.
DR RefSeq; XP_006531886.1; XM_006531823.3.
DR RefSeq; XP_006531887.1; XM_006531824.3.
DR RefSeq; XP_006531888.1; XM_006531825.3.
DR RefSeq; XP_006531889.1; XM_006531826.2.
DR AlphaFoldDB; Q8VE92; -.
DR SMR; Q8VE92; -.
DR BioGRID; 211657; 2.
DR IntAct; Q8VE92; 1.
DR MINT; Q8VE92; -.
DR STRING; 10090.ENSMUSP00000038256; -.
DR iPTMnet; Q8VE92; -.
DR PhosphoSitePlus; Q8VE92; -.
DR EPD; Q8VE92; -.
DR jPOST; Q8VE92; -.
DR MaxQB; Q8VE92; -.
DR PaxDb; Q8VE92; -.
DR PeptideAtlas; Q8VE92; -.
DR PRIDE; Q8VE92; -.
DR ProteomicsDB; 255006; -.
DR DNASU; 66704; -.
DR Ensembl; ENSMUST00000036744; ENSMUSP00000038256; ENSMUSG00000033760.
DR Ensembl; ENSMUST00000182821; ENSMUSP00000157674; ENSMUSG00000033760.
DR Ensembl; ENSMUST00000235278; ENSMUSP00000157500; ENSMUSG00000033760.
DR GeneID; 66704; -.
DR KEGG; mmu:66704; -.
DR UCSC; uc008gar.1; mouse.
DR CTD; 83759; -.
DR MGI; MGI:1913954; Rbm4b.
DR VEuPathDB; HostDB:ENSMUSG00000033760; -.
DR eggNOG; KOG0109; Eukaryota.
DR GeneTree; ENSGT00940000154421; -.
DR HOGENOM; CLU_045263_0_0_1; -.
DR InParanoid; Q8VE92; -.
DR OMA; GERTRCY; -.
DR OrthoDB; 1563362at2759; -.
DR PhylomeDB; Q8VE92; -.
DR TreeFam; TF320661; -.
DR BioGRID-ORCS; 66704; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8VE92; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8VE92; protein.
DR Bgee; ENSMUSG00000033760; Expressed in seminiferous tubule of testis and 164 other tissues.
DR ExpressionAtlas; Q8VE92; baseline and differential.
DR Genevisible; Q8VE92; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IDA:UniProtKB.
DR GO; GO:0007623; P:circadian rhythm; IDA:UniProtKB.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IDA:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI.
DR GO; GO:0006417; P:regulation of translation; IDA:UniProtKB.
DR CDD; cd12606; RRM1_RBM4; 1.
DR CDD; cd12607; RRM2_RBM4; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034897; RBM4_RRM1.
DR InterPro; IPR034898; RBM4_RRM2.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR001878; Znf_CCHC.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00360; RRM; 2.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 1: Evidence at protein level;
KW Activator; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..357
FT /note="RNA-binding protein 4B"
FT /id="PRO_0000081788"
FT DOMAIN 2..72
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 78..148
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT ZN_FING 160..177
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 196..357
FT /note="Interaction with TNPO3"
FT /evidence="ECO:0000250"
SQ SEQUENCE 357 AA; 39991 MW; 3BD8274D837DCC28 CRC64;
MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED AIRNLHHYKL
HGVNINVEAS KNKSKASTKL HVGNISPTCT NQELRAKFEE YGPVIECDIV KDYAFVHMER
AEDAVEAIRG LDNTEFQGKR MHVQLSTSRL RTAPGMGDQS GCYRCGKEGH WSKECPVDRT
GRVADFTEQY NEQYGAVRTP YTMGYGESMY YNDAYGALDY YKRYRVRSYE AVAAAAAASA
YNYAEQTMSH LPQVQSSAVP SHLNSTSVDP YDRHLLQNSG SAATSAAMAA AASSSYYGRD
RSPLRRNAAV LPAVGEGYGY GPESEMSQAS AATRNSLYDM ARYEREQYVD RTRYSAF
