RBM4B_PIG
ID RBM4B_PIG Reviewed; 359 AA.
AC Q06AT9;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=RNA-binding protein 4B;
DE AltName: Full=RNA-binding motif protein 30;
DE AltName: Full=RNA-binding motif protein 4B;
DE AltName: Full=RNA-binding protein 30;
GN Name=RBM4B; Synonyms=RBM30;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Liu G.Y.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the translational activation of PER1 mRNA in
CC response to circadian clock. Binds directly to the 3'-UTR of the PER1
CC mRNA (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TNPO3, which may mediate nuclear import of the
CC protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ917636; ABI97181.1; -; mRNA.
DR RefSeq; NP_001116660.1; NM_001123188.1.
DR AlphaFoldDB; Q06AT9; -.
DR SMR; Q06AT9; -.
DR STRING; 9823.ENSSSCP00000013750; -.
DR PeptideAtlas; Q06AT9; -.
DR PRIDE; Q06AT9; -.
DR Ensembl; ENSSSCT00000014136; ENSSSCP00000013750; ENSSSCG00000038304.
DR Ensembl; ENSSSCT00015039007; ENSSSCP00015015513; ENSSSCG00015029362.
DR Ensembl; ENSSSCT00025105858; ENSSSCP00025047387; ENSSSCG00025076440.
DR Ensembl; ENSSSCT00030011204; ENSSSCP00030004985; ENSSSCG00030008238.
DR Ensembl; ENSSSCT00050016466; ENSSSCP00050006764; ENSSSCG00050012196.
DR GeneID; 100144418; -.
DR KEGG; ssc:100144418; -.
DR CTD; 83759; -.
DR eggNOG; KOG0109; Eukaryota.
DR GeneTree; ENSGT00940000163468; -.
DR InParanoid; Q06AT9; -.
DR OMA; RYEREPY; -.
DR OrthoDB; 1563362at2759; -.
DR ChiTaRS; RBM4B; pig.
DR Proteomes; UP000008227; Chromosome 2.
DR Proteomes; UP000314985; Unplaced.
DR Bgee; ENSSSCG00000038304; Expressed in testis and 44 other tissues.
DR ExpressionAtlas; Q06AT9; baseline.
DR GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0007623; P:circadian rhythm; ISS:UniProtKB.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; ISS:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0006417; P:regulation of translation; ISS:UniProtKB.
DR CDD; cd12606; RRM1_RBM4; 1.
DR CDD; cd12607; RRM2_RBM4; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034897; RBM4_RRM1.
DR InterPro; IPR034898; RBM4_RRM2.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR001878; Znf_CCHC.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00360; RRM; 2.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 2: Evidence at transcript level;
KW Activator; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..359
FT /note="RNA-binding protein 4B"
FT /id="PRO_0000289661"
FT DOMAIN 2..72
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 78..148
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT ZN_FING 160..177
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 196..359
FT /note="Interaction with TNPO3"
FT /evidence="ECO:0000250"
SQ SEQUENCE 359 AA; 40054 MW; 20DAF2B93DD679A9 CRC64;
MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED AIRNLHHYKL
HGVNINVEAS KNKSKASTKL HVGNISPTCT NQELRAKFEE YGPVIECDIV KDYAFVHMER
AEDAVEAIRG LDNTEFQGKR MHVQLSTSRL RTAPGMGDQS GCYRCGKEGH WSKECPVDRT
GRVADFTEQY NEQYGAVRPP YTMGYGESMY YNDAYGALDY YKRYRVRSYE AVAAAAAASA
YNYAEQTMSH LPQVQSTAVT SHLNSTSVDP YDRHLLPNSG AAATSAAMAA AAATTSSYYG
RDRSPLRRAA AVLPTVGEGY GYGPESELSQ ASAAARNSLY DMARYEREQY VDRARYSAF
