ID   RBM4B_RAT               Reviewed;         357 AA.
AC   Q64LC9; Q5U1X3;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 2.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=RNA-binding protein 4B;
DE   AltName: Full=RNA-binding motif protein 30;
DE   AltName: Full=RNA-binding motif protein 4B;
DE   AltName: Full=RNA-binding protein 30;
DE   AltName: Full=Zinc-responsive protein ZD7;
GN   Name=Rbm4b; Synonyms=Rbm30;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=15361827; DOI=10.1038/sj.onc.1207974;
RA   Ishii H., Vecchione A., Furukawa Y., Croce C.M., Huebner K., Fong L.Y.Y.;
RT   "Differentially expressed genes execute zinc-induced apoptosis in
RT   precancerous esophageal epithelium of zinc-deficient rats.";
RL   Oncogene 23:8040-8048(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for the translational activation of PER1 mRNA in
CC       response to circadian clock. Binds directly to the 3'-UTR of the PER1
CC       mRNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TNPO3, which may mediate nuclear import of the
CC       protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
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DR   EMBL; AY303541; AAQ73500.1; -; mRNA.
DR   EMBL; BC086416; AAH86416.1; -; mRNA.
DR   RefSeq; NP_001007015.2; NM_001007014.2.
DR   AlphaFoldDB; Q64LC9; -.
DR   SMR; Q64LC9; -.
DR   IntAct; Q64LC9; 1.
DR   STRING; 10116.ENSRNOP00000026605; -.
DR   iPTMnet; Q64LC9; -.
DR   PhosphoSitePlus; Q64LC9; -.
DR   PaxDb; Q64LC9; -.
DR   Ensembl; ENSRNOT00000084410; ENSRNOP00000071527; ENSRNOG00000061795.
DR   GeneID; 474154; -.
DR   KEGG; rno:474154; -.
DR   UCSC; RGD:1359343; rat.
DR   CTD; 83759; -.
DR   RGD; 1359343; Rbm4b.
DR   eggNOG; KOG0109; Eukaryota.
DR   GeneTree; ENSGT00940000154421; -.
DR   HOGENOM; CLU_045263_0_0_1; -.
DR   InParanoid; Q64LC9; -.
DR   OMA; YGAFDYY; -.
DR   OrthoDB; 1563362at2759; -.
DR   PhylomeDB; Q64LC9; -.
DR   TreeFam; TF320661; -.
DR   PRO; PR:Q64LC9; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000061795; Expressed in testis and 20 other tissues.
DR   Genevisible; Q64LC9; RN.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
DR   GO; GO:0007623; P:circadian rhythm; ISS:UniProtKB.
DR   GO; GO:0043153; P:entrainment of circadian clock by photoperiod; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR   GO; GO:0006417; P:regulation of translation; ISS:UniProtKB.
DR   CDD; cd12606; RRM1_RBM4; 1.
DR   CDD; cd12607; RRM2_RBM4; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034897; RBM4_RRM1.
DR   InterPro; IPR034898; RBM4_RRM2.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR001878; Znf_CCHC.
DR   Pfam; PF00076; RRM_1; 2.
DR   Pfam; PF00098; zf-CCHC; 1.
DR   SMART; SM00360; RRM; 2.
DR   SMART; SM00343; ZnF_C2HC; 1.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   2: Evidence at transcript level;
KW   Activator; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger.
FT   CHAIN           1..357
FT                   /note="RNA-binding protein 4B"
FT                   /id="PRO_0000081789"
FT   DOMAIN          2..72
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          78..148
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   ZN_FING         160..177
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT   REGION          196..357
FT                   /note="Interaction with TNPO3"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        186
FT                   /note="F -> L (in Ref. 1; AAQ73500)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   357 AA;  39991 MW;  3BD8274D9261BC39 CRC64;
     MVKLFIGNLP REATEQEIRS LFEQYGKVLE CDIIKNYGFV HIEDKTAAED AIRNLHHYKL
     HGVNINVEAS KNKSKASTKL HVGNISPTCT NQELRAKFEE YGPVIECDIV KDYAFVHMER
     AEDAVEAIRG LDNTEFQGKR MHVQLSTSRL RTAPGMGDQS GCYRCGKEGH WSKECPVDRT
     GRVADFTEQY NEQYGAVRTP YTMGYGESMY YNDAYGALDY YKRYRVRSYE AVAAAAAASA
     YNYAEQTMSH LPQVQSSAVP SHLNSTSVDP YDRHLLQNSG SAATSAAMAA AASSSYYGRD
     RSPLRRNAAV LPTVGEGYGY GPESEMSQAS AATRNSLYDM ARYEREQYVD RARYSAF