ID   RBMS1_RAT               Reviewed;         403 AA.
AC   Q5PQP1;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=RNA-binding motif, single-stranded-interacting protein 1;
GN   Name=Rbms1 {ECO:0000312|EMBL:AAH87094.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAH87094.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart {ECO:0000312|EMBL:AAH87094.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Single-stranded DNA binding protein that interacts with the
CC       region upstream of the MYC gene. Binds specifically to the DNA sequence
CC       motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P29558}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC087094; AAH87094.1; -; mRNA.
DR   RefSeq; NP_001012184.1; NM_001012184.1.
DR   AlphaFoldDB; Q5PQP1; -.
DR   SMR; Q5PQP1; -.
DR   STRING; 10116.ENSRNOP00000011682; -.
DR   jPOST; Q5PQP1; -.
DR   PaxDb; Q5PQP1; -.
DR   PRIDE; Q5PQP1; -.
DR   GeneID; 362138; -.
DR   KEGG; rno:362138; -.
DR   UCSC; RGD:1307777; rat.
DR   CTD; 5937; -.
DR   RGD; 1307777; Rbms1.
DR   VEuPathDB; HostDB:ENSRNOG00000008482; -.
DR   eggNOG; KOG4733; Eukaryota.
DR   InParanoid; Q5PQP1; -.
DR   OrthoDB; 810893at2759; -.
DR   PRO; PR:Q5PQP1; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000008482; Expressed in lung and 19 other tissues.
DR   ExpressionAtlas; Q5PQP1; baseline and differential.
DR   Genevisible; Q5PQP1; RN.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR   GO; GO:0008143; F:poly(A) binding; IBA:GO_Central.
DR   GO; GO:0008266; F:poly(U) RNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd12470; RRM1_MSSP1; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR034404; MSSP1_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   DNA replication; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   Repeat; RNA-binding.
FT   CHAIN           1..403
FT                   /note="RNA-binding motif, single-stranded-interacting
FT                   protein 1"
FT                   /id="PRO_0000293625"
FT   DOMAIN          62..135
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          141..226
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          30..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         208
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P29558"
SQ   SEQUENCE   403 AA;  44068 MW;  4DAE522D5B53545A CRC64;
     MGKVWKQQMY PQYATYYYPQ YLQAKQSLVP AHPMAPPSPS TTSSNNNSSS SSNSGWDQLS
     KTNLYIRGLP PNTTDQDLVK LCQPYGKIVS TKAILDKATN KCKGYGFVDF DSPAAAQKAV
     SALKASGVQA QMAKQQEQDP TNLYISNLPL SMDEQELENM LKPFGQVIST RVLRDSSGTS
     RGVGFARMES TEKCEAVIGH FNGKFIKTPP GVSAPTEPLL CKFADGGQKK RQNPNKYIPN
     GRPWPREGEA GMTLTYDPTT AALHNGFYPS PYSIATNRMI TQTSLTPYIA SPVSAYQVQS
     PSWMQPQPYI LQHPGAVLTP SMEHTMSLQP ASMISPLAQQ MSHLSLGSTG TYMPATSAMQ
     GAYLPQYTHM QTATVPVEEA SGQQQVTVET SNDHSPYTFP PNK