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RBMS2_MOUSE
ID   RBMS2_MOUSE             Reviewed;         383 AA.
AC   Q8VC70;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=RNA-binding motif, single-stranded-interacting protein 2;
GN   Name=Rbms2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Ovary;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Heart, and Lung;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BC021627; AAH21627.1; -; mRNA.
DR   EMBL; AK054482; BAC35797.1; -; mRNA.
DR   CCDS; CCDS24261.1; -.
DR   RefSeq; NP_001034169.1; NM_001039080.1.
DR   RefSeq; NP_062685.2; NM_019711.2.
DR   RefSeq; XP_006513962.1; XM_006513899.2.
DR   RefSeq; XP_006513963.1; XM_006513900.2.
DR   AlphaFoldDB; Q8VC70; -.
DR   SMR; Q8VC70; -.
DR   BioGRID; 208029; 2.
DR   STRING; 10090.ENSMUSP00000089664; -.
DR   iPTMnet; Q8VC70; -.
DR   PhosphoSitePlus; Q8VC70; -.
DR   MaxQB; Q8VC70; -.
DR   PaxDb; Q8VC70; -.
DR   PeptideAtlas; Q8VC70; -.
DR   PRIDE; Q8VC70; -.
DR   ProteomicsDB; 255134; -.
DR   Antibodypedia; 28267; 212 antibodies from 24 providers.
DR   DNASU; 56516; -.
DR   Ensembl; ENSMUST00000092033; ENSMUSP00000089664; ENSMUSG00000040043.
DR   GeneID; 56516; -.
DR   KEGG; mmu:56516; -.
DR   UCSC; uc007hlm.1; mouse.
DR   CTD; 5939; -.
DR   MGI; MGI:1861776; Rbms2.
DR   VEuPathDB; HostDB:ENSMUSG00000040043; -.
DR   eggNOG; KOG4733; Eukaryota.
DR   GeneTree; ENSGT00940000155250; -.
DR   InParanoid; Q8VC70; -.
DR   OMA; DHGIYSF; -.
DR   OrthoDB; 810893at2759; -.
DR   PhylomeDB; Q8VC70; -.
DR   TreeFam; TF314644; -.
DR   BioGRID-ORCS; 56516; 3 hits in 72 CRISPR screens.
DR   ChiTaRS; Rbms2; mouse.
DR   PRO; PR:Q8VC70; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q8VC70; protein.
DR   Bgee; ENSMUSG00000040043; Expressed in placenta labyrinth and 214 other tissues.
DR   ExpressionAtlas; Q8VC70; baseline and differential.
DR   Genevisible; Q8VC70; MM.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR   GO; GO:0008143; F:poly(A) binding; IBA:GO_Central.
DR   GO; GO:0008266; F:poly(U) RNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR002343; Hud_Sxl_RNA.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   PRINTS; PR00961; HUDSXLRNA.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   1: Evidence at protein level;
KW   Acetylation; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..383
FT                   /note="RNA-binding motif, single-stranded-interacting
FT                   protein 2"
FT                   /id="PRO_0000081801"
FT   DOMAIN          58..131
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          137..222
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          28..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          352..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15434"
FT   MOD_RES         108
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15434"
FT   MOD_RES         287
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15434"
SQ   SEQUENCE   383 AA;  40724 MW;  2CD11874A92CEBEF CRC64;
     MLLSVTSRPG ISTFGYNKNN KKLYVAQQMA PPSPRNSTPN SSGGGGGGSG GNDQLSKTNL
     YIRGLQPGTT DQDLVKLCQP YGKIVSTKAI LDKTTNKCKG YGFVDFDSPS SAQKAVTALK
     ASGVQAQMAK QQEQDPTNLY ISNLPLSMDE QELEGMLKPF GQVISTRILR DTSGASRGVG
     FARMESTEKC EAIITHFNGK YIKTPPGVAA PSDPLLCKFA DGGPKKRQSQ GRYVQNGRAW
     PRNGDMGGMA LTYDPTAALQ NGFYAAPYSI AHSRMLAQSA LAPYLPSPVS SYQGSVLTPG
     MDHPLSLQPA SMMGPLTQQL GHLSLNSLGT FMPAAAAMHG AYISQYPAVP SSSVSAEESN
     GQQNQLAVEP PSDHGVYPFQ FSK
 
 
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