RBMS3_HUMAN
ID RBMS3_HUMAN Reviewed; 437 AA.
AC Q6XE24; A8K9S4; B7ZL17; G5E9J9; O75876; Q17RI0; Q6XE23;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=RNA-binding motif, single-stranded-interacting protein 3;
GN Name=RBMS3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), FUNCTION, RNA-BINDING, TISSUE
RP SPECIFICITY, AND SUBCELLULAR LOCATION.
RC TISSUE=Fibroblast;
RX PubMed=10675610; DOI=10.1016/s0378-1119(99)00515-6;
RA Penkov D., Ni R., Else C., Pinol-Roma S., Ramirez F., Tanaka S.;
RT "Cloning of a human gene closely related to the genes coding for the c-myc
RT single-strand binding proteins.";
RL Gene 243:27-36(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
RA Lee Y.-H., Tokraks S., Bogardus C., Permana P.A.;
RT "Cloning and characterization of novel alternatively spliced transcripts of
RT RBMS3: skeletal muscle mRNA level correlates with whole body insulin
RT resistance.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Binds poly(A) and poly(U) oligoribonucleotides.
CC {ECO:0000269|PubMed:10675610}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10675610}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1; Synonyms=DD23-L;
CC IsoId=Q6XE24-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6XE24-2; Sequence=VSP_022928, VSP_022930, VSP_022931;
CC Name=3; Synonyms=DD23-S;
CC IsoId=Q6XE24-3; Sequence=VSP_022927, VSP_022929;
CC Name=4;
CC IsoId=Q6XE24-4; Sequence=VSP_022930, VSP_022931;
CC Name=5;
CC IsoId=Q6XE24-5; Sequence=VSP_022930;
CC -!- TISSUE SPECIFICITY: Expressed in fetal brain, fetal lung, fetal liver,
CC heart, brain, placenta, lung, liver, muscle, kidney and pancreas.
CC {ECO:0000269|PubMed:10675610}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC63910.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF023259; AAC63910.1; ALT_FRAME; mRNA.
DR EMBL; AY236871; AAP75555.1; -; mRNA.
DR EMBL; AY236872; AAP75556.1; -; mRNA.
DR EMBL; AK292789; BAF85478.1; -; mRNA.
DR EMBL; AC012262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC021068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC097633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC098650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC099048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471055; EAW64405.1; -; Genomic_DNA.
DR EMBL; BC117315; AAI17316.1; -; mRNA.
DR EMBL; BC143521; AAI43522.1; -; mRNA.
DR CCDS; CCDS33724.1; -. [Q6XE24-1]
DR CCDS; CCDS33725.1; -. [Q6XE24-3]
DR CCDS; CCDS33726.1; -. [Q6XE24-4]
DR CCDS; CCDS54557.1; -. [Q6XE24-2]
DR CCDS; CCDS54558.1; -. [Q6XE24-5]
DR RefSeq; NP_001003792.1; NM_001003792.2. [Q6XE24-3]
DR RefSeq; NP_001003793.1; NM_001003793.2. [Q6XE24-1]
DR RefSeq; NP_001171182.1; NM_001177711.1. [Q6XE24-5]
DR RefSeq; NP_001171183.1; NM_001177712.1. [Q6XE24-2]
DR RefSeq; NP_055298.2; NM_014483.3. [Q6XE24-4]
DR AlphaFoldDB; Q6XE24; -.
DR SMR; Q6XE24; -.
DR BioGRID; 118126; 47.
DR IntAct; Q6XE24; 5.
DR STRING; 9606.ENSP00000373277; -.
DR iPTMnet; Q6XE24; -.
DR PhosphoSitePlus; Q6XE24; -.
DR BioMuta; RBMS3; -.
DR DMDM; 74762382; -.
DR EPD; Q6XE24; -.
DR jPOST; Q6XE24; -.
DR MassIVE; Q6XE24; -.
DR MaxQB; Q6XE24; -.
DR PaxDb; Q6XE24; -.
DR PeptideAtlas; Q6XE24; -.
DR PRIDE; Q6XE24; -.
DR ProteomicsDB; 33960; -.
DR ProteomicsDB; 67796; -. [Q6XE24-1]
DR ProteomicsDB; 67797; -. [Q6XE24-2]
DR ProteomicsDB; 67798; -. [Q6XE24-3]
DR ProteomicsDB; 67799; -. [Q6XE24-4]
DR Antibodypedia; 11544; 190 antibodies from 25 providers.
DR DNASU; 27303; -.
DR Ensembl; ENST00000273139.13; ENSP00000273139.9; ENSG00000144642.22. [Q6XE24-4]
DR Ensembl; ENST00000383766.6; ENSP00000373276.2; ENSG00000144642.22. [Q6XE24-3]
DR Ensembl; ENST00000383767.7; ENSP00000373277.2; ENSG00000144642.22. [Q6XE24-1]
DR Ensembl; ENST00000452462.5; ENSP00000397926.1; ENSG00000144642.22. [Q6XE24-5]
DR Ensembl; ENST00000456853.1; ENSP00000400519.1; ENSG00000144642.22. [Q6XE24-2]
DR GeneID; 27303; -.
DR KEGG; hsa:27303; -.
DR MANE-Select; ENST00000383767.7; ENSP00000373277.2; NM_001003793.3; NP_001003793.1.
DR UCSC; uc003cek.4; human. [Q6XE24-1]
DR CTD; 27303; -.
DR DisGeNET; 27303; -.
DR GeneCards; RBMS3; -.
DR HGNC; HGNC:13427; RBMS3.
DR HPA; ENSG00000144642; Low tissue specificity.
DR MIM; 605786; gene.
DR neXtProt; NX_Q6XE24; -.
DR OpenTargets; ENSG00000144642; -.
DR PharmGKB; PA34276; -.
DR VEuPathDB; HostDB:ENSG00000144642; -.
DR eggNOG; KOG4733; Eukaryota.
DR GeneTree; ENSGT00940000157131; -.
DR InParanoid; Q6XE24; -.
DR OMA; HTPAYSY; -.
DR OrthoDB; 810893at2759; -.
DR PhylomeDB; Q6XE24; -.
DR TreeFam; TF314644; -.
DR PathwayCommons; Q6XE24; -.
DR SignaLink; Q6XE24; -.
DR BioGRID-ORCS; 27303; 9 hits in 1065 CRISPR screens.
DR ChiTaRS; RBMS3; human.
DR GenomeRNAi; 27303; -.
DR Pharos; Q6XE24; Tbio.
DR PRO; PR:Q6XE24; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6XE24; protein.
DR Bgee; ENSG00000144642; Expressed in trigeminal ganglion and 189 other tissues.
DR ExpressionAtlas; Q6XE24; baseline and differential.
DR Genevisible; Q6XE24; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; IDA:UniProtKB.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0008143; F:poly(A) binding; IDA:UniProtKB.
DR GO; GO:0008266; F:poly(U) RNA binding; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0002357; P:defense response to tumor cell; IMP:UniProtKB.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IMP:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR CDD; cd12475; RRM2_RBMS3; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR002343; Hud_Sxl_RNA.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034406; RBMS3_RRM2.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR PRINTS; PR00961; HUDSXLRNA.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..437
FT /note="RNA-binding motif, single-stranded-interacting
FT protein 3"
FT /id="PRO_0000274906"
FT DOMAIN 61..134
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 140..225
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 28..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 26
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_022927"
FT VAR_SEQ 247
FT /note="G -> GEVLRGRTVPRQNR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022928"
FT VAR_SEQ 297..313
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_022929"
FT VAR_SEQ 351..366
FT /note="Missing (in isoform 2, isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:10675610,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334"
FT /id="VSP_022930"
FT VAR_SEQ 437
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:10675610,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_022931"
FT CONFLICT 93
FT /note="I -> L (in Ref. 2; AAP75556)"
FT /evidence="ECO:0000305"
FT CONFLICT 165
FT /note="H -> P (in Ref. 2; AAP75556)"
FT /evidence="ECO:0000305"
FT CONFLICT 418
FT /note="I -> V (in Ref. 3; BAF85478)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 437 AA; 47840 MW; 7EFC2ECFE24E323C CRC64;
MGKRLDQPQM YPQYTYYYPH YLQTKQSYAP APHPMAPPSP STNSSSNNSS NNSSGEQLSK
TNLYIRGLPP GTTDQDLIKL CQPYGKIVST KAILDKNTNQ CKGYGFVDFD SPAAAQKAVA
SLKANGVQAQ MAKQQEQDPT NLYISNLPIS MDEQELENML KPFGHVISTR ILRDANGVSR
GVGFARMEST EKCEVVIQHF NGKYLKTPPG IPAPSEPLLC KFADGGQKKR QNQSKYTQNG
RPWPREGEAG MALTYDPTAA IQNGFYSSPY SIATNRMIPQ TSITPFIAAS PVSTYQVQST
SWMPHPPYVM QPTGAVITPT MDHPMSMQPA NMMGPLTQQM NHLSLGTTGT IQSQDRIMIL
HQLLCQYMTA AAPMQGTYIP QYTPVPPTAV SIEGVVADTS PQTVAPSSQD TSGQQQQIAV
DTSNEHAPAY SYQQSKP
