RBMS3_MOUSE
ID RBMS3_MOUSE Reviewed; 431 AA.
AC Q8BWL5; Q2VPR0; Q8BL73; Q8BLW6; Q8BMA7; Q8BMB5; Q8BML0; Q8BMN1;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=RNA-binding motif, single-stranded-interacting protein 3;
GN Name=Rbms3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6).
RC STRAIN=C57BL/6J;
RC TISSUE=Aorta, Corpora quadrigemina, Heart, Pituitary, Vein, and
RC Wolffian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Binds poly(A) and poly(U) oligoribonucleotides.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q8BWL5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BWL5-2; Sequence=VSP_022934;
CC Name=3;
CC IsoId=Q8BWL5-3; Sequence=VSP_022933;
CC Name=4;
CC IsoId=Q8BWL5-4; Sequence=VSP_022934, VSP_022935;
CC Name=5;
CC IsoId=Q8BWL5-5; Sequence=VSP_022932, VSP_022933;
CC Name=6;
CC IsoId=Q8BWL5-6; Sequence=VSP_022935;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC34878.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK030478; BAC26980.1; -; mRNA.
DR EMBL; AK030609; BAC27045.1; -; mRNA.
DR EMBL; AK032938; BAC28091.1; -; mRNA.
DR EMBL; AK033005; BAC28122.1; -; mRNA.
DR EMBL; AK041098; BAC30820.1; -; mRNA.
DR EMBL; AK046197; BAC32633.1; -; mRNA.
DR EMBL; AK052196; BAC34878.1; ALT_INIT; mRNA.
DR EMBL; BC108402; AAI08403.1; -; mRNA.
DR EMBL; BC117841; AAI17842.1; -; mRNA.
DR CCDS; CCDS40798.1; -. [Q8BWL5-3]
DR CCDS; CCDS52955.1; -. [Q8BWL5-2]
DR CCDS; CCDS52956.1; -. [Q8BWL5-6]
DR CCDS; CCDS52957.1; -. [Q8BWL5-1]
DR CCDS; CCDS57711.1; -. [Q8BWL5-4]
DR CCDS; CCDS57712.1; -. [Q8BWL5-5]
DR RefSeq; NP_001165592.1; NM_001172121.1. [Q8BWL5-5]
DR RefSeq; NP_001165593.1; NM_001172122.1. [Q8BWL5-2]
DR RefSeq; NP_001165594.1; NM_001172123.1. [Q8BWL5-1]
DR RefSeq; NP_001165595.1; NM_001172124.1. [Q8BWL5-6]
DR RefSeq; NP_001165597.1; NM_001172126.1. [Q8BWL5-4]
DR RefSeq; NP_848775.2; NM_178660.4. [Q8BWL5-3]
DR AlphaFoldDB; Q8BWL5; -.
DR SMR; Q8BWL5; -.
DR STRING; 10090.ENSMUSP00000107403; -.
DR iPTMnet; Q8BWL5; -.
DR PhosphoSitePlus; Q8BWL5; -.
DR MaxQB; Q8BWL5; -.
DR PaxDb; Q8BWL5; -.
DR PRIDE; Q8BWL5; -.
DR ProteomicsDB; 255043; -. [Q8BWL5-1]
DR ProteomicsDB; 255044; -. [Q8BWL5-2]
DR ProteomicsDB; 255045; -. [Q8BWL5-3]
DR ProteomicsDB; 255046; -. [Q8BWL5-4]
DR ProteomicsDB; 255047; -. [Q8BWL5-5]
DR ProteomicsDB; 255048; -. [Q8BWL5-6]
DR Antibodypedia; 11544; 190 antibodies from 25 providers.
DR DNASU; 207181; -.
DR Ensembl; ENSMUST00000044901; ENSMUSP00000039706; ENSMUSG00000039607. [Q8BWL5-4]
DR Ensembl; ENSMUST00000068962; ENSMUSP00000066735; ENSMUSG00000039607. [Q8BWL5-3]
DR Ensembl; ENSMUST00000111772; ENSMUSP00000107402; ENSMUSG00000039607. [Q8BWL5-2]
DR Ensembl; ENSMUST00000111773; ENSMUSP00000107403; ENSMUSG00000039607. [Q8BWL5-1]
DR Ensembl; ENSMUST00000164018; ENSMUSP00000131371; ENSMUSG00000039607. [Q8BWL5-5]
DR Ensembl; ENSMUST00000174868; ENSMUSP00000133621; ENSMUSG00000039607. [Q8BWL5-6]
DR GeneID; 207181; -.
DR KEGG; mmu:207181; -.
DR UCSC; uc009ryv.3; mouse. [Q8BWL5-3]
DR UCSC; uc009ryw.3; mouse. [Q8BWL5-1]
DR UCSC; uc009ryx.3; mouse. [Q8BWL5-2]
DR UCSC; uc009ryy.3; mouse. [Q8BWL5-6]
DR UCSC; uc009ryz.3; mouse. [Q8BWL5-4]
DR UCSC; uc009rza.3; mouse. [Q8BWL5-5]
DR CTD; 27303; -.
DR MGI; MGI:2444477; Rbms3.
DR VEuPathDB; HostDB:ENSMUSG00000039607; -.
DR eggNOG; KOG4733; Eukaryota.
DR GeneTree; ENSGT00940000157131; -.
DR HOGENOM; CLU_016278_2_0_1; -.
DR InParanoid; Q8BWL5; -.
DR OMA; HTPAYSY; -.
DR OrthoDB; 810893at2759; -.
DR PhylomeDB; Q8BWL5; -.
DR TreeFam; TF314644; -.
DR BioGRID-ORCS; 207181; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Rbms3; mouse.
DR PRO; PR:Q8BWL5; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8BWL5; protein.
DR Bgee; ENSMUSG00000039607; Expressed in vas deferens and 215 other tissues.
DR ExpressionAtlas; Q8BWL5; baseline and differential.
DR Genevisible; Q8BWL5; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; ISO:MGI.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IDA:MGI.
DR GO; GO:0008143; F:poly(A) binding; ISO:MGI.
DR GO; GO:0008266; F:poly(U) RNA binding; ISO:MGI.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0002357; P:defense response to tumor cell; ISO:MGI.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISO:MGI.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:0045727; P:positive regulation of translation; IDA:MGI.
DR CDD; cd12475; RRM2_RBMS3; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR002343; Hud_Sxl_RNA.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034406; RBMS3_RRM2.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR PRINTS; PR00961; HUDSXLRNA.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..431
FT /note="RNA-binding motif, single-stranded-interacting
FT protein 3"
FT /id="PRO_0000274907"
FT DOMAIN 56..129
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 135..220
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 28..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..26
FT /note="MGKRLDQPQMYPQYTYYCPQYLQTKQ -> MEGGRLLIRSNANGVTQSNSTV
FT RAYQSSKSRVTMSPGFSSQWSNSQPAWNTYSFPRASLHYQSHASYTYCTGHPV (in
FT isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022932"
FT VAR_SEQ 292..308
FT /note="Missing (in isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_022933"
FT VAR_SEQ 346..361
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022934"
FT VAR_SEQ 388..431
FT /note="GVVADTSPQTVAPSSQDSSGQQQQLAVDTPSEHAPAYSFQQSKP -> TIDR
FT SEDVCLNLYLQ (in isoform 4 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022935"
FT CONFLICT 10
FT /note="M -> I (in Ref. 1; BAC26980)"
FT /evidence="ECO:0000305"
FT CONFLICT 20
FT /note="Q -> H (in Ref. 1; BAC26980)"
FT /evidence="ECO:0000305"
FT CONFLICT 309
FT /note="G -> S (in Ref. 2; AAI08403)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 431 AA; 46927 MW; 65D096613FDF783A CRC64;
MGKRLDQPQM YPQYTYYCPQ YLQTKQSYAP APHPMAPPSP STNSSSNSSG EQLSKTNLYI
RGLPPGTTDQ DLIKLCQPYG KIVSTKAILD KNTNQCKGYG FVDFDSPAAA QKAVASLKAN
GVQAQMAKQQ EQDPTNLYIS NLPISMDEQE LENMLKPFGH VISTRILRDA NGVSRGVGFA
RMESTEKCEV VIQHFNGKYL KTPPGIPAPS EPLLCKFADG GQKKRQGQSK HTQNGRPWPR
EGEAGMALTY DPTAALQNGF YSSPYSLATN RMIPQTSITP FIAASPVSTY QVQSTSWTPH
LPYIMQPTGA VITPAVDHPM SMQPTNIVGP LTQQMNHLSL GTAGTIQSQD RIMVLHQLLC
QYMTAAPMQG TYIPQYTPVP PTAVSIEGVV ADTSPQTVAP SSQDSSGQQQ QLAVDTPSEH
APAYSFQQSK P
