RBMX_XENLA
ID RBMX_XENLA Reviewed; 370 AA.
AC Q6IRQ4;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=RNA-binding motif protein, X chromosome;
DE AltName: Full=Heterogeneous nuclear ribonucleoprotein G;
DE Short=hnRNP G;
GN Name=rbmx;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=18521943; DOI=10.1002/dvdy.21590;
RA Dichmann D.S., Fletcher R.B., Harland R.M.;
RT "Expression cloning in Xenopus identifies RNA-binding proteins as
RT regulators of embryogenesis and Rbmx as necessary for neural and muscle
RT development.";
RL Dev. Dyn. 237:1755-1766(2008).
CC -!- FUNCTION: RNA-binding protein that plays several role in the regulation
CC of pre- and post-transcriptional processes. Implicated in tissue-
CC specific regulation of gene transcription and alternative splicing of
CC pre-mRNAs. Associates with chromatin. Associates with nascent mRNAs
CC transcribed by RNA polymerase II. Component of the supraspliceosome
CC complex that regulates pre-mRNA alternative splice site selection.
CC Binds non-specifically to pre-mRNAs (By similarity). Required for
CC embryonic development, in particular of the brain. {ECO:0000250,
CC ECO:0000269|PubMed:18521943}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the anterior to posterior extent of
CC the neural tube including strong expression in the forebrain in the
CC embryo. {ECO:0000269|PubMed:18521943}.
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DR EMBL; BC070649; AAH70649.1; -; mRNA.
DR RefSeq; NP_001084981.1; NM_001091512.1.
DR AlphaFoldDB; Q6IRQ4; -.
DR SMR; Q6IRQ4; -.
DR PRIDE; Q6IRQ4; -.
DR DNASU; 432041; -.
DR GeneID; 432041; -.
DR CTD; 432041; -.
DR Xenbase; XB-GENE-6078824; rbmx.S.
DR OMA; DAQQWNG; -.
DR OrthoDB; 1248417at2759; -.
DR Proteomes; UP000186698; Genome assembly.
DR Bgee; 432041; Expressed in gastrula and 19 other tissues.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; ISS:UniProtKB.
DR GO; GO:0000791; C:euchromatin; ISS:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0044530; C:supraspliceosomal complex; ISS:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR GO; GO:0003729; F:mRNA binding; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0071347; P:cellular response to interleukin-1; ISS:UniProtKB.
DR GO; GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:UniProtKB.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR012604; RBM1CTR.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR Pfam; PF08081; RBM1CTR; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Ribonucleoprotein; RNA-binding; Spliceosome;
KW Transcription.
FT CHAIN 1..370
FT /note="RNA-binding motif protein, X chromosome"
FT /id="PRO_0000413021"
FT DOMAIN 8..86
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 69..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..143
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 370 AA; 40299 MW; 1BEC68054CFD57A1 CRC64;
MVEADRPGKL FIGGLNTETN EKALEAVFCK YGRVVEVLLM KDRETNKSRG FAFVTFESPA
DAKDAARELN GKALDGKPIK VEQATKPSFS TPSRRGPPTS PRSRGPPRGL RGSRGGGSSR
GQMPLKRGPP PRSGGPPPKR SAPSGPLRSS EMGGRAPLSR ERDGYGAPPR RDPMPSRRDV
YMSPRDDGYS GKDRYDGYSG RDYGSSRDSR DYGPPPRDYS YRDYGHSSSR DDYGSRGYSD
RDGYGGRDSR DYSDHQSGGS YRDSYEGYGN SRSAPPARGP PPSYGGSSRY DDYSSTRDGY
GGRDSYSSSR NDIYSSGRDR VGRQERGLPP SMDRGYPPPR DSYSSSSRGG PRGGGRGGSR
SDRGGGRSRY
