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RBP10_DANRE
ID   RBP10_DANRE             Reviewed;         604 AA.
AC   Q1LUS8; A5WVR4;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Ran-binding protein 10;
DE            Short=RanBP10;
GN   Name=ranbp10; ORFNames=si:dkey-16n13.2;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: May act as an adapter protein to couple membrane receptors to
CC       intracellular signaling pathways. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RANBP9/10 family. {ECO:0000305}.
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DR   EMBL; BX927240; CAK05294.1; -; Genomic_DNA.
DR   EMBL; CT025923; CAN87952.1; -; Genomic_DNA.
DR   EMBL; CT573140; CAN87952.1; JOINED; Genomic_DNA.
DR   EMBL; CT573140; CAN88227.1; -; Genomic_DNA.
DR   EMBL; CT025923; CAN88227.1; JOINED; Genomic_DNA.
DR   RefSeq; NP_001038515.1; NM_001045050.2.
DR   AlphaFoldDB; Q1LUS8; -.
DR   SMR; Q1LUS8; -.
DR   STRING; 7955.ENSDARP00000123657; -.
DR   PaxDb; Q1LUS8; -.
DR   GeneID; 793293; -.
DR   KEGG; dre:793293; -.
DR   CTD; 57610; -.
DR   ZFIN; ZDB-GENE-070705-86; ranbp10.
DR   eggNOG; KOG1477; Eukaryota.
DR   HOGENOM; CLU_009129_4_0_1; -.
DR   InParanoid; Q1LUS8; -.
DR   OrthoDB; 1106989at2759; -.
DR   PhylomeDB; Q1LUS8; -.
DR   TreeFam; TF331658; -.
DR   Reactome; R-DRE-8851805; MET activates RAS signaling.
DR   PRO; PR:Q1LUS8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR   CDD; cd12909; SPRY_RanBP9_10; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR013144; CRA_dom.
DR   InterPro; IPR024964; CTLH/CRA.
DR   InterPro; IPR006595; CTLH_C.
DR   InterPro; IPR006594; LisH.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035782; SPRY_RanBP9/10.
DR   Pfam; PF10607; CLTH; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00757; CRA; 1.
DR   SMART; SM00668; CTLH; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50897; CTLH; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..604
FT                   /note="Ran-binding protein 10"
FT                   /id="PRO_0000305239"
FT   DOMAIN          23..210
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   DOMAIN          241..273
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   DOMAIN          279..336
FT                   /note="CTLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00058"
FT   REGION          342..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..436
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        475
FT                   /note="V -> VGNGVA (in Ref. 1; CAN87952/CAN88227)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   604 AA;  66486 MW;  9E2516A0CC6656E8 CRC64;
     MAELGAGSLL TGDPAFNYQE HELNERLKRL YPAVNEEETP LPRSWSPKDK YSYIGLSQNN
     LRVHYKGHGK NHKDAASVRA THPIPAACGI YYFEVKIVSK GRDGYMGIGL SAQGVNMNRL
     PGWDKHSYGY HGDDGHSFCS SGTGQPYGPT FTTGDVIGCC VNLINNTCFY TKNGHSLGVA
     FTDLPPNLYP TVGLQTPGEI VDANFGQQPF VFDIEDYMSE WRAKIHSMIA RFPIGERLGD
     WQAVLQNMVS SYLVHHGYCA TAMAFARATE TMIQEDQTSI KNRQRIQKLV LAGRVGEAID
     ATQQLYPGLL EHNPNLLFML KCRQFVEMVN GTDSEVRCFS VRSPKSQDSY PGSPNMSPRH
     GATNPHLHST GADSPTCSNG VTPPNKNKSH NKYTGISSAS SSPSSSPSSV NYSESNSTDS
     TKSQPHSATS NQETSDSEME IEAEHYSNGV TESSTRIMNG TYKHQEILQA DDNSVDDTCS
     SRQLCGGNQA ATERMIQFGR ELQTLSEQLC RQYGKNATHK KMLQDAFSLL AYSDPWNCPV
     GQQLDPMQRE AICSALNSAI LESQNLPKQP PLMLALGQAT ECVQLMARVR SGSCSFARVD
     NFLH
 
 
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