RBP10_DANRE
ID RBP10_DANRE Reviewed; 604 AA.
AC Q1LUS8; A5WVR4;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Ran-binding protein 10;
DE Short=RanBP10;
GN Name=ranbp10; ORFNames=si:dkey-16n13.2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: May act as an adapter protein to couple membrane receptors to
CC intracellular signaling pathways. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RANBP9/10 family. {ECO:0000305}.
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DR EMBL; BX927240; CAK05294.1; -; Genomic_DNA.
DR EMBL; CT025923; CAN87952.1; -; Genomic_DNA.
DR EMBL; CT573140; CAN87952.1; JOINED; Genomic_DNA.
DR EMBL; CT573140; CAN88227.1; -; Genomic_DNA.
DR EMBL; CT025923; CAN88227.1; JOINED; Genomic_DNA.
DR RefSeq; NP_001038515.1; NM_001045050.2.
DR AlphaFoldDB; Q1LUS8; -.
DR SMR; Q1LUS8; -.
DR STRING; 7955.ENSDARP00000123657; -.
DR PaxDb; Q1LUS8; -.
DR GeneID; 793293; -.
DR KEGG; dre:793293; -.
DR CTD; 57610; -.
DR ZFIN; ZDB-GENE-070705-86; ranbp10.
DR eggNOG; KOG1477; Eukaryota.
DR HOGENOM; CLU_009129_4_0_1; -.
DR InParanoid; Q1LUS8; -.
DR OrthoDB; 1106989at2759; -.
DR PhylomeDB; Q1LUS8; -.
DR TreeFam; TF331658; -.
DR Reactome; R-DRE-8851805; MET activates RAS signaling.
DR PRO; PR:Q1LUS8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR CDD; cd12909; SPRY_RanBP9_10; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR013144; CRA_dom.
DR InterPro; IPR024964; CTLH/CRA.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035782; SPRY_RanBP9/10.
DR Pfam; PF10607; CLTH; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00757; CRA; 1.
DR SMART; SM00668; CTLH; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50896; LISH; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..604
FT /note="Ran-binding protein 10"
FT /id="PRO_0000305239"
FT DOMAIN 23..210
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT DOMAIN 241..273
FT /note="LisH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT DOMAIN 279..336
FT /note="CTLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00058"
FT REGION 342..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 475
FT /note="V -> VGNGVA (in Ref. 1; CAN87952/CAN88227)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 604 AA; 66486 MW; 9E2516A0CC6656E8 CRC64;
MAELGAGSLL TGDPAFNYQE HELNERLKRL YPAVNEEETP LPRSWSPKDK YSYIGLSQNN
LRVHYKGHGK NHKDAASVRA THPIPAACGI YYFEVKIVSK GRDGYMGIGL SAQGVNMNRL
PGWDKHSYGY HGDDGHSFCS SGTGQPYGPT FTTGDVIGCC VNLINNTCFY TKNGHSLGVA
FTDLPPNLYP TVGLQTPGEI VDANFGQQPF VFDIEDYMSE WRAKIHSMIA RFPIGERLGD
WQAVLQNMVS SYLVHHGYCA TAMAFARATE TMIQEDQTSI KNRQRIQKLV LAGRVGEAID
ATQQLYPGLL EHNPNLLFML KCRQFVEMVN GTDSEVRCFS VRSPKSQDSY PGSPNMSPRH
GATNPHLHST GADSPTCSNG VTPPNKNKSH NKYTGISSAS SSPSSSPSSV NYSESNSTDS
TKSQPHSATS NQETSDSEME IEAEHYSNGV TESSTRIMNG TYKHQEILQA DDNSVDDTCS
SRQLCGGNQA ATERMIQFGR ELQTLSEQLC RQYGKNATHK KMLQDAFSLL AYSDPWNCPV
GQQLDPMQRE AICSALNSAI LESQNLPKQP PLMLALGQAT ECVQLMARVR SGSCSFARVD
NFLH