RBP16_DROME
ID RBP16_DROME Reviewed; 1098 AA.
AC Q9GQN0; Q5BI24; Q9VXL6; Q9VXL7;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Ran-binding protein 16;
GN Name=Ranbp16; ORFNames=CG33180;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Goerlich D., Hartmann E.;
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function as a nuclear transport receptor. {ECO:0000250}.
CC -!- SUBUNIT: Binds to nucleoporins and the GTP-bound form of Ran.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UIA9}. Nucleus
CC {ECO:0000250|UniProtKB:Q9UIA9}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; AF222744; AAG44254.1; -; mRNA.
DR EMBL; AE014298; AAF48541.3; -; Genomic_DNA.
DR EMBL; BT021400; AAX33548.1; -; mRNA.
DR RefSeq; NP_001285308.1; NM_001298379.1.
DR RefSeq; NP_788913.2; NM_176740.4.
DR AlphaFoldDB; Q9GQN0; -.
DR SMR; Q9GQN0; -.
DR IntAct; Q9GQN0; 2.
DR STRING; 7227.FBpp0292664; -.
DR PaxDb; Q9GQN0; -.
DR EnsemblMetazoa; FBtr0074162; FBpp0089083; FBgn0053180.
DR EnsemblMetazoa; FBtr0340311; FBpp0309272; FBgn0053180.
DR GeneID; 118436; -.
DR KEGG; dme:Dmel_CG33180; -.
DR UCSC; CG33180-RB; d. melanogaster.
DR CTD; 118436; -.
DR FlyBase; FBgn0053180; Ranbp16.
DR VEuPathDB; VectorBase:FBgn0053180; -.
DR eggNOG; KOG1410; Eukaryota.
DR InParanoid; Q9GQN0; -.
DR PhylomeDB; Q9GQN0; -.
DR BioGRID-ORCS; 118436; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Ranbp16; fly.
DR GenomeRNAi; 118436; -.
DR PRO; PR:Q9GQN0; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0053180; Expressed in embryonic/larval hemocyte (Drosophila) and 25 other tissues.
DR ExpressionAtlas; Q9GQN0; baseline and differential.
DR Genevisible; Q9GQN0; DM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005643; C:nuclear pore; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005049; F:nuclear export signal receptor activity; ISS:UniProtKB.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006611; P:protein export from nucleus; ISS:UniProtKB.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR044189; XPO4/7-like.
DR InterPro; IPR040021; XPO7.
DR PANTHER; PTHR12596; PTHR12596; 1.
DR PANTHER; PTHR12596:SF11; PTHR12596:SF11; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT CHAIN 1..1098
FT /note="Ran-binding protein 16"
FT /id="PRO_0000204715"
SQ SEQUENCE 1098 AA; 125533 MW; C8A3885CB3FDAEF5 CRC64;
MDIQQLEVLC KQLYEATDIR IRSEAEKALV TFVSSQDALP KCQLLLQRAD SSYAQLLAAS
TLTKLIQGLS LQERIDIRSY ALNYLATVPN LQHFVVQALV SLLAKLTKYG WFDSYKEEMV
FQNLLEDVKK FLQGSVEHCT IGVQILSQLV CEMNSVVEMD VQVSFSKMRK IATSFRDQQL
LETFLLSCSL LVSARDNSKN ISFMDESQQA LISHVLRLTK NCLSFDFIGS STDESADDMN
NVQIPTAWRP AFLDSNTLKL FFDLYQILPN GLASYSISCL VQITSVRRSL FNNSERTKFL
THLVEGVKDI LTTLHGLSDP DNYHEFCRLL ARLKSNYQLG ELIAVPCYPE AIQLIAKFTV
ESLHLWLFAP NSVHYLLTLW QRMVASVPYV KSPDPHLLGT YTPEVIKAYI ESRLDAVPVI
IRDNLDDPLD DFCMVQQQLE QLSVIERCEY NKTCNLLVQH FDQKAREYEN LLQTPNANSI
DITIHELQLT WLVYIIGSAI VGRLTVATSD EHDTMDAELV IRVLQLMTLT DARLPQAGCE
KLELAILSFL DQVRKMHSSE QAQKANLNKR LSEVFGLTDE QMLLSFINRK IITNLKFWGR
SESIITKTLM LLSELSVHFN SVRKLARLEE VQFMLTHHTS EHFPFLGTNS SLSEMRCRTM
FYTSLGRLLM FDLGEDEERF YNFLEPLTNQ FESLGSVMMD NNIFSNEEAK KVIIGLARDL
RGLALPLNAR IQYTMLFEWL YYADYLPILL RAMDLWAHDP AVTTPILKLF AELVHCRTQR
LAGNVSSPMG ILLFREASKL ICIYGNRILH QEVPRERLYP MRLKGIAICF LILKNSLGGN
YVNCGVFKLY GDDTLDSVLN IIAKLILTIE QRDLIEYPKL STAYYNLLNC LSQDHVSYLA
ALEPAAFVYI LKSLTKGLAA LDSATYISCC TILDSIVSYI FKQLQMKVST FPNKKLRSLN
QENVQFLKVV EMNSELLQSM MSSLLNNVLQ EDCRNQWSMS RPLLVLILLY EDYYRSLKDR
IICAQPIEKQ QTMAQWFDDL MVGIERNVSS KNKEKFTQNM STFRRDVVNL PKSTAAFSCD
RPMCDGGFEP SEPESSPH
