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RBP17_HUMAN
ID   RBP17_HUMAN             Reviewed;        1088 AA.
AC   Q9H2T7; Q8IU74;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 159.
DE   RecName: Full=Ran-binding protein 17;
GN   Name=RANBP17;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=11071879; DOI=10.1006/bbrc.2000.3788;
RA   Koch P., Bohlmann I., Schaefer M., Hansen-Hagge T.E., Kiyoi H., Wilda M.,
RA   Hameister H., Bartram C.R., Janssen J.W.G.;
RT   "Identification of a novel putative Ran-binding protein and its close
RT   homologue.";
RL   Biochem. Biophys. Res. Commun. 278:241-249(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Cervix carcinoma;
RX   PubMed=11024021; DOI=10.1074/jbc.m006242200;
RA   Kutay U., Hartmann E., Treichel N., Calado A., Carmo-Fonseca M., Prehn S.,
RA   Kraft R., Goerlich D., Bischoff F.R.;
RT   "Identification of two novel RanGTP-binding proteins belonging to the
RT   importin beta superfamily.";
RL   J. Biol. Chem. 275:40163-40168(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RA   Hansen-Hagge T.E., Schaefer M., Kiyoi H., Bohlmann I., Koch P., Morris S.,
RA   Bartram C.R., Janssen J.W.;
RT   "Identification of a gene located at the chromosomal breakpoint
RT   t(5;14)(q33-q34;q11), a recurring chromosomal aberration in a subset of
RT   human acute leukemias.";
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-1088 (ISOFORM 1).
RC   TISSUE=Thyroid;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: May function as a nuclear transport receptor. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to nucleoporins and the GTP-bound form of Ran.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Nucleus, nuclear pore complex {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9H2T7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9H2T7-2; Sequence=VSP_056669, VSP_056670;
CC   -!- TISSUE SPECIFICITY: Highly expressed in testis, moderately in pancreas
CC       and weakly in other tissues studied. {ECO:0000269|PubMed:11071879}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB55427.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF222747; AAG44255.1; -; mRNA.
DR   EMBL; AJ288952; CAC81806.1; -; mRNA.
DR   EMBL; AJ288953; CAC81807.1; -; mRNA.
DR   EMBL; AJ288955; CAC81809.1; -; mRNA.
DR   EMBL; AC008514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC018753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC021077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471062; EAW61456.1; -; Genomic_DNA.
DR   EMBL; CH471062; EAW61457.1; -; Genomic_DNA.
DR   EMBL; CH471062; EAW61461.1; -; Genomic_DNA.
DR   EMBL; CH471062; EAW61463.1; -; Genomic_DNA.
DR   EMBL; AK027880; BAB55427.1; ALT_INIT; mRNA.
DR   CCDS; CCDS34287.1; -. [Q9H2T7-1]
DR   RefSeq; NP_075048.1; NM_022897.4. [Q9H2T7-1]
DR   AlphaFoldDB; Q9H2T7; -.
DR   SMR; Q9H2T7; -.
DR   BioGRID; 122341; 16.
DR   IntAct; Q9H2T7; 1.
DR   STRING; 9606.ENSP00000427975; -.
DR   TCDB; 1.I.1.1.3; the nuclear pore complex (npc) family.
DR   iPTMnet; Q9H2T7; -.
DR   PhosphoSitePlus; Q9H2T7; -.
DR   BioMuta; RANBP17; -.
DR   DMDM; 17368945; -.
DR   EPD; Q9H2T7; -.
DR   jPOST; Q9H2T7; -.
DR   MassIVE; Q9H2T7; -.
DR   MaxQB; Q9H2T7; -.
DR   PaxDb; Q9H2T7; -.
DR   PeptideAtlas; Q9H2T7; -.
DR   PRIDE; Q9H2T7; -.
DR   ProteomicsDB; 70515; -.
DR   ProteomicsDB; 80590; -. [Q9H2T7-1]
DR   Antibodypedia; 28854; 137 antibodies from 24 providers.
DR   DNASU; 64901; -.
DR   Ensembl; ENST00000389118.8; ENSP00000373770.4; ENSG00000204764.14. [Q9H2T7-2]
DR   Ensembl; ENST00000519256.5; ENSP00000429298.1; ENSG00000204764.14. [Q9H2T7-2]
DR   Ensembl; ENST00000519949.5; ENSP00000430444.1; ENSG00000204764.14. [Q9H2T7-2]
DR   Ensembl; ENST00000522533.5; ENSP00000430599.1; ENSG00000204764.14. [Q9H2T7-2]
DR   Ensembl; ENST00000523189.6; ENSP00000427975.1; ENSG00000204764.14. [Q9H2T7-1]
DR   GeneID; 64901; -.
DR   KEGG; hsa:64901; -.
DR   MANE-Select; ENST00000523189.6; ENSP00000427975.1; NM_022897.5; NP_075048.1.
DR   UCSC; uc003mba.4; human. [Q9H2T7-1]
DR   CTD; 64901; -.
DR   DisGeNET; 64901; -.
DR   GeneCards; RANBP17; -.
DR   HGNC; HGNC:14428; RANBP17.
DR   HPA; ENSG00000204764; Tissue enhanced (brain).
DR   MIM; 606141; gene.
DR   neXtProt; NX_Q9H2T7; -.
DR   OpenTargets; ENSG00000204764; -.
DR   PharmGKB; PA34208; -.
DR   VEuPathDB; HostDB:ENSG00000204764; -.
DR   eggNOG; KOG1410; Eukaryota.
DR   GeneTree; ENSGT00940000153139; -.
DR   HOGENOM; CLU_005409_0_0_1; -.
DR   InParanoid; Q9H2T7; -.
DR   OMA; DGNTEPC; -.
DR   OrthoDB; 198413at2759; -.
DR   PhylomeDB; Q9H2T7; -.
DR   TreeFam; TF314248; -.
DR   PathwayCommons; Q9H2T7; -.
DR   SignaLink; Q9H2T7; -.
DR   SIGNOR; Q9H2T7; -.
DR   BioGRID-ORCS; 64901; 7 hits in 1069 CRISPR screens.
DR   ChiTaRS; RANBP17; human.
DR   GenomeRNAi; 64901; -.
DR   Pharos; Q9H2T7; Tbio.
DR   PRO; PR:Q9H2T7; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q9H2T7; protein.
DR   Bgee; ENSG00000204764; Expressed in calcaneal tendon and 119 other tissues.
DR   ExpressionAtlas; Q9H2T7; baseline and differential.
DR   Genevisible; Q9H2T7; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; NAS:UniProtKB.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; NAS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR044189; XPO4/7-like.
DR   PANTHER; PTHR12596; PTHR12596; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Alternative splicing; Cytoplasm; mRNA transport;
KW   Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport;
KW   Reference proteome; Translocation; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UIA9"
FT   CHAIN           2..1088
FT                   /note="Ran-binding protein 17"
FT                   /id="PRO_0000204718"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UIA9"
FT   MOD_RES         569
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UIA9"
FT   VAR_SEQ         571..576
FT                   /note="VYARMS -> KTDIFL (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.3"
FT                   /id="VSP_056669"
FT   VAR_SEQ         577..1088
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.3"
FT                   /id="VSP_056670"
FT   CONFLICT        107
FT                   /note="L -> H (in Ref. 6; BAB55427)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        199
FT                   /note="V -> A (in Ref. 6; BAB55427)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1088 AA;  124375 MW;  A95D5599388EAEFB CRC64;
     MALHFQSLAE LEVLCTHLYI GTDLTQRIEA EKALLELIDS PECLSKCQLL LEQGTTSYAQ
     LLAATCLSKL VSRVSPLPVE QRMDIRNYIL NYVASQPKLA PFVIQALIQV IAKITKLGWF
     EVQKDQFVFR EIIADVKKFL QGTVEHCIIG VIILSELTQE MNLVDYSRPS AKHRKIATSF
     RDTSLKDVLV LACSLLKEVF AKPLNLQDQC QQNLVMQVLK LVLNCLNFDF IGSSADESAD
     DLCTVQIPTT WRTIFLEPET LDLFFNLYHS LPPLLSQLAL SCLVQFASTR RSLFNSPERA
     KYLGNLIKGV KRILENPQGL SDPGNYHEFC RFLARLKTNY QLGELVMVKE YPEVIRLIAN
     FTITSLQHWE FAPNSVHYLL TLWQRMVASV PFVKSTEPHL LDTYAPEITK AFITSRLDSV
     AIVVRDHLDD PLDDTATVFQ QLEQLCTVSR CEYEKTCALL VQLFDQNAQN YQKLLHPYSG
     VTVDITIQEG RLAWLVYLVG TVVGGRLTYT STDEHDAMDG ELSCRVFQLI SLMDTGLPRC
     CNEKIELAIL WFLDQFRKTY VGDQLQRTSK VYARMSEVLG ITDDNHVLET FMTKIVTNLK
     YWGRYEPVIS RTLQFLNDLS VGYILLKKLV KIDAVKFMLK NHTSEHFPFL GISDNHSLSD
     FRCRTTFYTA LTRLLMVDLG EDEDEFENFM LPLTVAFETV LQIFNNNFKQ EDVKRMLIGL
     ARDLRGIAFA LNTKTSYTML FDWMYPTYLP LLQNAVERWY GEPTCTTPIL KLMAELMQNR
     SQRLNFDVSS PNGILLFREA SKMVCTYGNQ ILSLGSLSKD QIYPMKLKGI SICYSALKSA
     LCGNYVSFGV FKLYGDNHFD NVLQAFVKML LSVSHSDLLQ YRKLSQSYYP LLECLTQDHM
     SFIINLEPPV LMYVLTSISE GLTTLDTVVS SSCCTSLDYI VTYLFKHIAK EGKKPLRCRE
     ATQAGQRLLH FMQQNPDVLQ QMMSVLMNTI VFEDCRNQWS VSRPLLGLIL LNEKYFSELR
     ASLINSQPLP KQEVLAQCFR NLMEGVEQNL SVKNRDRFTQ NLSVFRRDVA EALRSDGNTE
     PCSLDMMS
 
 
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