RBP17_MOUSE
ID RBP17_MOUSE Reviewed; 1088 AA.
AC Q99NF8; Q9D4E3;
DT 02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Ran-binding protein 17;
GN Name=Ranbp17;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=11071879; DOI=10.1006/bbrc.2000.3788;
RA Koch P., Bohlmann I., Schaefer M., Hansen-Hagge T.E., Kiyoi H., Wilda M.,
RA Hameister H., Bartram C.R., Janssen J.W.G.;
RT "Identification of a novel putative Ran-binding protein and its close
RT homologue.";
RL Biochem. Biophys. Res. Commun. 278:241-249(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May function as a nuclear transport receptor. {ECO:0000250}.
CC -!- SUBUNIT: Binds to nucleoporins and the GTP-bound form of Ran.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Nucleus, nuclear pore complex {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in primary spermatocytes and very
CC weakly in pancreas. {ECO:0000269|PubMed:11071879}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; AJ271458; CAC28935.1; -; mRNA.
DR EMBL; AK016583; BAB30322.1; -; mRNA.
DR CCDS; CCDS24534.1; -.
DR RefSeq; NP_075635.1; NM_023146.2.
DR AlphaFoldDB; Q99NF8; -.
DR SMR; Q99NF8; -.
DR STRING; 10090.ENSMUSP00000099879; -.
DR iPTMnet; Q99NF8; -.
DR PhosphoSitePlus; Q99NF8; -.
DR MaxQB; Q99NF8; -.
DR PaxDb; Q99NF8; -.
DR PRIDE; Q99NF8; -.
DR ProteomicsDB; 253184; -.
DR Antibodypedia; 28854; 137 antibodies from 24 providers.
DR DNASU; 66011; -.
DR Ensembl; ENSMUST00000102815; ENSMUSP00000099879; ENSMUSG00000040594.
DR GeneID; 66011; -.
DR KEGG; mmu:66011; -.
DR UCSC; uc007ikh.2; mouse.
DR CTD; 64901; -.
DR MGI; MGI:1929706; Ranbp17.
DR VEuPathDB; HostDB:ENSMUSG00000040594; -.
DR eggNOG; KOG1410; Eukaryota.
DR GeneTree; ENSGT00940000153139; -.
DR HOGENOM; CLU_005409_0_0_1; -.
DR InParanoid; Q99NF8; -.
DR OMA; DGNTEPC; -.
DR OrthoDB; 198413at2759; -.
DR PhylomeDB; Q99NF8; -.
DR TreeFam; TF314248; -.
DR BioGRID-ORCS; 66011; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Ranbp17; mouse.
DR PRO; PR:Q99NF8; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q99NF8; protein.
DR Bgee; ENSMUSG00000040594; Expressed in spermatocyte and 86 other tissues.
DR ExpressionAtlas; Q99NF8; baseline and differential.
DR Genevisible; Q99NF8; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; TAS:MGI.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006913; P:nucleocytoplasmic transport; TAS:MGI.
DR GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR044189; XPO4/7-like.
DR PANTHER; PTHR12596; PTHR12596; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; mRNA transport; Nuclear pore complex; Nucleus;
KW Phosphoprotein; Protein transport; Reference proteome; Translocation;
KW Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9UIA9"
FT CHAIN 2..1088
FT /note="Ran-binding protein 17"
FT /id="PRO_0000204719"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9UIA9"
FT MOD_RES 569
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UIA9"
FT CONFLICT 128
FT /note="V -> I (in Ref. 2; BAB30322)"
FT /evidence="ECO:0000305"
FT CONFLICT 469
FT /note="Q -> K (in Ref. 2; BAB30322)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1088 AA; 124054 MW; 69D73355E358B6E3 CRC64;
MALHFQSLAE LEVLCTHLYV GTDLTERIEA EKALLELIDS PECLSKCQLL LEQGTTSYAQ
LLAATCLSKL VTRINPLPIE QRIDIRNYIL NYVASQPKLA PFVIQALIQV IAKLTKLGWF
EVQKDEFVFR EIIADVKKFL QGTVEHCIIG VIILCELTQE MNLVDYSRPS AKHRKIATSF
RDTSLKDILV LACSLLKQVL AKPLNLQDQD QQSLVMQVLK LVLSCLNFDF LGSSADESAD
DLCTVQIPTT WRTIFLEPET LDLFFNLYHS LPPLLSQLAL SCLVQFASTR RSLFSSPERA
KYLGNLIKGV KRILENPQGL SDPGNYHEFC RFLARLKTNY QLGELVLVKE YAEVIGLIAN
FTITSLQHWE FAPNSVHYLL TLWQRMVASV PFVKSAEPHL LDTYAPEITK AFITSRLESV
AIVVRDNLED PLDDTATVFQ QLEQLCTVSR CEYEKTCTLL VQLFDQNAQN YQKLLHAAPG
LAVDMAIQEG RLAWLIYLVG TVVGGRLTYT STDEHDAMDG ELSCRVFQLI SLMDTRLPHC
TNEKIELAVL WFLDQFRKTY VGDQLQRTSK VYARMSEVLG ITDDNHVLET FMTKIVTNLK
YWGRCEPVIS RTLQFLSDLS VGYILLKKLV KIDAVKFMLK NHTSEHFPFL GISETYNVGD
FRCRTTFYTA LTRLLMVDLG EDEDEFENFM LPLTVSFETV LQIFNNNFKQ EEVKRMLIGL
ARDLRGIAFA LNTKTSYTML FDWIYPAYLP VLQRAIERWY GEPACTTPIL KLLAELMQNR
SQRLNFDVSS PNGILLFREA SKMICTYGNQ ILSLGSLSKD KIYPMKLKGI SICYSALKSA
LCGNYVSFGV FKLYGDNHFD NVLQAFVKML LSVSHSDLLQ YRKLSQSYYP LLECLTQDHM
SFITNLEPPV LLYVLTSLSE GLTTLDTVVS SSCCTSLDYM VTYLFKHIAK EGKKPLRSRE
AMQAGQRLLH FMQQNPDVLQ QMMSVLMNTI VFEDCRNQWS VSRPLLGLIL LNEKYFSELR
ASLINSQPLP KQEVLGQCFR NLMEGVEQNL SVKNRDRFTQ NLSVFRRDVA EALRSDGHTD
LSSLDMMS
