RBP1_PLAVB
ID RBP1_PLAVB Reviewed; 2833 AA.
AC Q00798;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 3.
DT 02-JUN-2021, entry version 65.
DE RecName: Full=Reticulocyte-binding protein 1;
DE Flags: Precursor;
GN Name=RBP1;
OS Plasmodium vivax (strain Belem).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=31273;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1617731; DOI=10.1016/0092-8674(92)90642-p;
RA Galinski M.R., Medina C.C., Ingravallo P., Barnwell J.W.;
RT "A reticulocyte-binding protein complex of Plasmodium vivax merozoites.";
RL Cell 69:1213-1226(1992).
RN [2]
RP SEQUENCE REVISION TO 987-996; 1070; 1238-1240; 1524; 1559-1567; 1764; 1821;
RP 1902 AND 2061-2063.
RA Tran T.M., Galinski M.R.;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in reticulocyte adhesion. Specifically binds to
CC human reticulocyte cells.
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
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DR EMBL; M88097; AAA29743.3; -; Genomic_DNA.
DR SMR; Q00798; -.
DR PRIDE; Q00798; -.
DR GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR GO; GO:0098609; P:cell-cell adhesion; IDA:UniProtKB.
PE 3: Inferred from homology;
KW Malaria; Membrane; Receptor; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..2833
FT /note="Reticulocyte-binding protein 1"
FT /id="PRO_0000024576"
FT REGION 75..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2619..2755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 2563..2565
FT /note="Cell attachment site"
FT /evidence="ECO:0000255"
FT COMPBIAS 117..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2623..2654
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2655..2670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2671..2709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2833 AA; 326161 MW; E4DF3ED1CE7504B3 CRC64;
MKRGICLAAL LCLFNYLGAG HGENAEEDIR NSEGKVNFFS LDSNLKKNKK SKHNRVKRRN
AKISNFLSQK AYVKETDNAS GKDAEGSRPS HDSSFVNLNG HVDGKSLSYS VHVKESTPHS
TTRESTEKGK ENEKIQGVLS SFVQSQEGGE SDDLEGMYNS IVDMSEKLKE NDKYNLVFDM
EIDFVDLQFF NLILELIPKD SQYHTYYEET LKQQVTEYTN SLKTLMDSCI SEKDQMIILE
YEINYAKRKS IETETLGDKE TKLSAVSQAY AKHLESYKGV LKPKLNDIKN NAFSVLKDSY
CKDNCGEYVQ KYNTMRKNFI SSSDQYKMEA YVYIPKSIND YTVLDKILSE SNELGIDIQE
TVNSLKLLGE EISEVSHLYV INSTLIDDAA KKLESINEED ESAEIDLQKF EDNSKALANN
YCIFQYIKTL NEPIKKAYES KVIKSNELLS TIIDTLGKSA TALQESTFDQ EECNKIKTEA
EKVKDDAEDI CEKNEQIYYE IPESEDETID DKINDLQDLI DQMKEYKDEI VNNSEFISNR
YKNIYENLKE TYETELNDIG KLENDTSKVN FYLMQIRKIN TEKTKIDESL QTVEKFYKEI
LDSKEKIYEL KIEFEKSVTE INRLQDGESA RDLHEEQIKE ILDKMAKKVH YLKELLSLKG
KSSVYFTEMN ELLNTASYDN MEGFSAKKEK ADNDINALYN SVYREDINAL IEEVEKFVTE
NKESTLEMLK DEEMEEKLQD AKETFAKLNF VSDDKLTDVY TKMSAEVTNA EGIKKEIAQK
QFENVHKKMK EFSDAFSTKF EALQNSMQQY NQEGDAIEKH KQNRSEKEEE YFKNESVEED
LSREETEEQE YTKHKNNFSR RKGEISAEIT NMREVINKIE SQLNYYGVIE KYFSLIGDQN
EVSTAKALKE KIVSDSLRDK IDQYETEFKE KTSAVENTVS TIQSLSKAID SLKRLNGSIN
NCKKYNTDID LLRSKIKTLR EEVQKEIAET EGDKVVGENT TALLLKSLRD KMGKINEKLN
DGRLNSLDTK KEDLLKFYSE SKSKIHLSKD QKGPQDPLNR IDEWEDIKRE VDELNVNYQV
ISENKVTLFK NNSVTYIEAM HSHINTVAHG ITSNKNEILK SVKEVEDKLN LVEQNEDYKK
VKNPENEKQL EAIRGSMSKL KEVINKHVSE MTQLESTANT LKSNAKGKEN EHDLEELNKT
KGQMRDIYEK LKKIAEELKE GTVNELKDAN EKANKVELEF ERNIIGHVLE RITVEKDKAG
KVVEEMNSLK TKIEKLIQET SDDSQNELVT TSITKHLENA KGYEDVIKRN EEDSIQLREK
AKSLETLDEM KKLVQQVNMN LQSAIQGNAG ISKELNELKG VIELLISTNY SSILEYVKKN
SSESVRFSQL ANGEFTKAEG EEKNASARLA EAEKLKEQIV KDLDYSDIDD KVKKIEGIKR
EILKMKESAL TFWEESEKFK QMCSSHMENA KEGKKKIEYL KNNGDGGKAN ITDSQMEEVG
NYVSKAEHAF HTVEAQVDKT KAFYESIVAY VTKMDNLFNE SLMKEVKVKC EKKNDEAEQI
FGQIKTVDGR IKARVSENER KISELKEKAK VEKKESSQLN DVSTKSLLQI DNCRQQLDSV
LSNIGRVKQN ALQYFDSADK SMKSVLPISE LGAEKSLDKV KAAKESYEKN LETVQNEMSR
INVEEGSLTD IDKKITDIEN DLLKMKKQYE EGLLQKIKEN ADKRKSNFEL VGSEINALLD
PSTSIFIKLK LKEYDMTGDL KNYAVKMNEI HGEFTKSYNL IETHLSNATD YSVTFEKAQS
LRELAEKEEE HLRRREEEAI KLLNDIKKVE SLKLLKEMMK KVSAEYEGMK RDHTSVSQLV
QDMKTIVDEL KTLNDISECS SVLNNVVSIV KKVKESKHAD YKRDANSMYE SMVTLANYFL
SDEAKISSGM EFNAEMKSNF KTDLELEIFS VISNSNELLK KIEQDSNDVI QKERESEQLA
KDATDIYNVI KLKNEFNEKL EEAKNKEEVV SEKVREALKR LSQVEGIRCH FENFHRLLDN
TEELENLKKM VTIYRDKKSE APKESGLQEM ENEMNTYSNS ITQLEGIVVS AGESKEDIEK
LERSNEEMRN ISEKISTIDS KVIEMNSTID ELYKLGKNCQ AHWISLISYT ANMKTSKKLI
MINKEKENTE KCVDYIKDNS SSTDGYVETL KGFYGSKLTF SSASEIVQNA DTYSVNFAKH
EKESLNAIRD IKKELYLFHQ NSDISIVEGG VQNMLALYDK LNEEKREMDE LYRNISETKL
KQMEHSTDVF KPMIELHKGM NETNNKSLLE KEKKLKSVND HMHSMEAEMI KNGLKYTPES
VQNINNIYSV IEAEVKTLEE IDRDYGDNYQ IVEEHKKQFS ILIDRTNALM DDIEIFKKEN
NYNLMEVNTE TIHRVNDYIE KITNKLVQAK TEYEQILENI KQNDDMLQNI FLKKVSIIEY
FENVKKKKES ILNDLYEQER LLKIGEHLDE IKRNVTETLS SYEIDQKMEM MSKNLLEKKS
KMMNYTSIYE LEREANEINR DAKQIKDDDT ILNSVLEAAI QKRGDMDAIF SQMSADRNPN
EYKSAEKYMN EANEIIRQLE VKLREIGQLV QDSESILSEM NSKKSAIEKE KTARALRTSE
NNRREEEERA RVQEMSMNND PTQSETTHSE GSIGEGKESD SDETGLTHDA GADEDSTSSA
KGAHELEEEE TTAPMEETEM NDNTLLGYDT TRSDEPDMHT ENTQDGTYQD TSNSSDEADI
LNGKFNFNNV KYAGAFVLLC TSAVIGAIIA HKKDDQEELN NGVEDDKVFE VKKSMHPENK
EEIIDDSFVD IEY
