ID   RBP2_PLAVB              Reviewed;        2867 AA.
AC   Q00799; Q9N2M3;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 2.
DT   02-JUN-2021, entry version 69.
DE   RecName: Full=Reticulocyte-binding protein 2;
DE   AltName: Full=PvRBP-2;
DE   Flags: Precursor;
GN   Name=RBP-2; Synonyms=RBP2;
OS   Plasmodium vivax (strain Belem).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=31273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION TO 2438-2439.
RX   PubMed=10838229; DOI=10.1016/s0166-6851(00)00219-x;
RA   Galinski M.R., Xu M., Barnwell J.W.;
RT   "Plasmodium vivax reticulocyte binding protein-2 (PvRBP-2) shares
RT   structural features with PvRBP-1 and the Plasmodium yoelii 235 kDa rhoptry
RT   protein family.";
RL   Mol. Biochem. Parasitol. 108:257-262(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1189-2439.
RX   PubMed=1617731; DOI=10.1016/0092-8674(92)90642-p;
RA   Galinski M.R., Medina C.C., Ingravallo P., Barnwell J.W.;
RT   "A reticulocyte-binding protein complex of Plasmodium vivax merozoites.";
RL   Cell 69:1213-1226(1992).
CC   -!- FUNCTION: Involved in reticulocyte adhesion. Specifically binds to
CC       human reticulocyte cells.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; AF184623; AAF76525.1; -; Genomic_DNA.
DR   SMR; Q00799; -.
DR   PRIDE; Q00799; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0098609; P:cell-cell adhesion; IDA:UniProtKB.
PE   3: Inferred from homology;
KW   Cell membrane; Malaria; Membrane; Receptor; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..2867
FT                   /note="Reticulocyte-binding protein 2"
FT                   /id="PRO_0000024577"
FT   TOPO_DOM        22..2805
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2806..2826
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        2827..2867
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          2758..2761
FT                   /note="1"
FT   REPEAT          2762..2765
FT                   /note="2"
FT   REPEAT          2766..2769
FT                   /note="3"
FT   REPEAT          2770..2773
FT                   /note="4"
FT   REPEAT          2774..2777
FT                   /note="5"
FT   REPEAT          2778..2781
FT                   /note="6"
FT   REPEAT          2782..2785
FT                   /note="7"
FT   REGION          52..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2650..2682
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2712..2799
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2758..2785
FT                   /note="7 X 4 AA tandem repeats of H-D-D-T"
FT   COMPBIAS        2650..2671
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2720..2743
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2758..2799
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2867 AA;  331436 MW;  6E7D8CA71AFBFFD3 CRC64;
     MEKNVLWVIF YNFLVILLAS CNDSNRSKSN SLKSESKSLP TYANLMRNGQ DKYNNAKTED
     NIGNQINNDN NHNGYNDNRI NSEYPKTSHL QHSPSLVHLN DHKFTTKPSR HSYVQRNSIY
     KRNTNNNMEN TNNELHVVPN FFIQEKKAAP QKPSVQNTPT ATQIVYNNLD YLNAFDDTNN
     IISAFKPHHP IIYYFKQLEH FANSYYDLRN KIKDYFALPM KQASDVVEKN VKDCLQNINE
     SRILMTQLEN PQNYNDISDK YDEKVKEYKK KIEDMQICLK DSYIKNFKAI MSANLKMNLA
     LNGIYIHWWY LTCSTKTYDD IVKEYAIEIN DFDEKKSISF MDNMKKIHKS AIDTLKKMKA
     ELNTSLDSKR TEFIIGEIGH MIEKFNLHLT KIRYASAFIK SIPLQKVESD IYRVELKTLF
     YVAAKHYADF KFSLEHLKMF ENLSKSKEKM LYSTFEKLEG DLLNKINTLM GSEQSTSDLT
     SIIADSEKII KSAESLINSS SEEIAKYALD SNEKINEIKK NYDQNILKVR EFINKSNGLI
     TSVKGTSQLS ESDKQQIETK IEEIKKKKKD ILERGKEFIN IMNEIKKKKK SNSSNSSTNS
     KEFTDKLKEL ETEFEGLNKT VKGYLQEIED IKVKENEDRS LKNQIEQHLK YTSDNRDNVK
     TLISKNDEIQ KYIEKIEKLI NDAPSGKDKF TTEKTNLQNK VKKIIDEFHK EDLQLLLNSL
     SKFYEEHQKL YNEASTIEKI KDLHQKTKEE YEKLEKMKFS NFGQILDKLN TELDNLKTLE
     KNIVEEQTNY INKVMSDSLT NLTAEVDNLR SALDGYRADE TELKTYKNRI NERKEKFLST
     LKEQEDDIPD GKNIYEEYNN HKNVMVNKEH KISSDINQCN ENIIKAEKNL ETFNTLVQTL
     DAHTGKKDQK VHDLLQKFKT NLEKLNLNEL ESGFKSLNGS ASTTNKQIEN IRKNIDTIKS
     LNFAKNSSES SKLSLENIIK NKADLIKKLD QHTQEIEKHT FIENEEMSPL LSVIKKEKNR
     VESDMSEELI KQLNTKINAI LEYYNKSKDR FNGDDETNLE ELDDFKKQCQ DAQQEIKKLT
     TNYNVLDNGI NVIIKEQHEK VIILSENHIT EKDKKINEKI QQNVNSLNEM KTKLGLLKIN
     EDIKNSRDTT IKSKIQEFEK KVQTIFGSID VANKKIDAIK KEHDVNKDEF DKEKVKDTSF
     DEKKKSIEKA YEKMGNTLKE LEKMDDEKNI EKEVEEAQIQ YKRIFIDHDV NLMNDEVEKS
     KIVMEKIELY KKEIDEIKQK TNEYKQGDTS NFYYTEQYNS ATQSKAKIEQ FINIATTKKG
     TSDTSQDINE LESIKEEVHK NLQLVKQESN SMEEMRKQIL SMKDLLILNN SETIAKEISN
     NTQNALGFRE NAKTKLNKTD ELLQRVAAMI EEAKAHKNNI DIALEDAQID TEVSKIEQIN
     REIMNKKDEI KSYLSEIKEY KDKCTTEISN SKRGKDKIEF LEKFKPNEES NSNKVNINEI
     NENIRNSEQY LKDIEDAEKQ ASTKVELFHK HETTISNIFK ESEILGVETK SQKKINKAED
     IMKEIERHNS EIQTQVKGFQ ENLNKLNEPH NYDNAEDELN NDKSTNAKVL IETNLESVKH
     NLSEITNIKQ GGEKIYSKAK DIMQKIKATS ENTAEKTLEK VKDDQSNYVN YLNQITTERN
     LIVTEKNRLN GIDSTITNIE GALKESKGNY EIGFLEKLEE IGKNRKLKVD ITKKSINSTV
     GNFSSLFNNF DLNQYDFNKN INDYENKMGE IYNEFEGSLN KISENLRNAS ENTSDYNSAK
     TLRLEAQKEK VNLLNKEEEA NKYLRDVKKV ESFRFIFNMK ESLDKINEMI KKEQLTVNEG
     HGNVKQLVEN IKELVDENNL SDILKQATGK NEEIQKITHS TLKNKAKTIL GHVDTSAKYV
     GIKITPELAL TELLGDAKLK TAQELKFESK NNVVLETENM SKNTNELDVH KNIQDAYKVA
     LEILAHSDEI DTKQKDSSKL IEMGNQIYLK VVLINQYKNK ISSIKSKEEA VSVKIGNVSK
     KHSELSKITC SDKSYDNIIA LEKQTELQNL RNSFTQEKTN TNSDSKLEKI KTDFESLKNA
     LKTLEGEVNA LKASSDNHEH VQSKSEPVNP ALSEIEKEET DIDSLNTALD ELLKKGRTCE
     VSRYKLIKDT VTKEISDDTE LINTIEKNVK AYLAYIKKNY EDTVQDVLTL NEHFNTKQVS
     NHEPTNFDKS NKSSEELTKA VTDSKTIISK LKGVIIEVNE NTEMNTIESS AKEIEALYNE
     LKNKKTSLNE IYQTSNEVKL QEMKSNADKY IDVSKIFNTV LDTQKSNIVT NQHSINNVKD
     KLKGKLQELI DADSSFTLES IKKFNEIYSH IKTNIGELEQ LQQTNKSEHD NVAKHKEKIV
     HLINRVESLK GDVKNHDDDQ YMKKLNASLL NDNIKNTNSI NISDEELKKL LKKVEENDQL
     CKNNNTQNFI SDIMKRVEDL NRRFTENLPE KEKLHQIENN YNEISSIFSE INLQDVDEFV
     AKIHKQIDAE KASVNNVREA EKIRTAIQNV TSYDTEIISR LSEMNNVLER ITTRKTKMDQ
     LLKSLSPDNT SLNLNARTHV RKSEDIIKQL NSHIGEITEL NTYAHEVMTY LENELNKLLK
     QLEIERAKLE TKTSPSGMKA KEEKVPPKET ENRAQDNLAS VPQKTLEDNT QQMPENSVQD
     NLASVPQKTL EDNTHQMPEN RVQEDSISAP QEQVEYSTLA VPENDETTEE ESEHDDAHDD
     THDDTHDDTH DDTHDDTHDD THDDTHDESQ TGRDSTAKEA IGKTRLAGAV IIAMSVLSGF
     IIIVFKDKDE EEKDHNEHGY NEAFGEHDEY NMHDKEEVIE VCFNEED