RBP4A_XENLA
ID RBP4A_XENLA Reviewed; 425 AA.
AC O93377; Q6AZU0;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Histone-binding protein RBBP4-A;
DE AltName: Full=Retinoblastoma-binding protein 4-A;
DE Short=RBBP-4-A;
DE AltName: Full=Retinoblastoma-binding protein p48-A;
GN Name=rbbp4-a; Synonyms=rbap48-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH HDAC1-B; HISTONE H4
RP AND SIN3A, AND SUBCELLULAR LOCATION.
RX PubMed=10454532; DOI=10.1128/mcb.19.9.5847;
RA Vermaak D., Wade P.A., Jones P.L., Shi Y.-B., Wolffe A.P.;
RT "Functional analysis of the SIN3-histone deacetylase RPD3-RbAp48-histone H4
RT connection in the Xenopus oocyte.";
RL Mol. Cell. Biol. 19:5847-5860(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP INTERACTION WITH HDAC1; HDAC2; NCOR1 AND SIN3A.
RX PubMed=11254656; DOI=10.1074/jbc.c000879200;
RA Jones P.L., Sachs L.M., Rouse N., Wade P.A., Shi Y.-B.;
RT "Multiple N-CoR complexes contain distinct histone deacetylases.";
RL J. Biol. Chem. 276:8807-8811(2001).
CC -!- FUNCTION: Core histone-binding subunit that may target chromatin
CC assembly factors, chromatin remodeling factors and histone deacetylases
CC to their histone substrates in a manner that is regulated by
CC nucleosomal DNA. {ECO:0000269|PubMed:10454532}.
CC -!- SUBUNIT: Component of the DREAM complex (By similarity). Binds directly
CC to histone H4, probably via helix 1 of the histone fold, a region that
CC is not accessible when histone H4 is in chromatin (PubMed:10454532).
CC Probably forms a large corepressor complex that contains ncor1, sin3a,
CC hdac1-A and/or hdac1-B, hdac2, rbbp4-A and/or rbbp4-B and possibly
CC rbbp7 (PubMed:11254656). {ECO:0000250|UniProtKB:Q09028,
CC ECO:0000269|PubMed:10454532, ECO:0000269|PubMed:11254656}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q09028}.
CC Chromosome, telomere {ECO:0000250|UniProtKB:Q09028}.
CC -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC {ECO:0000305}.
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DR EMBL; AF073787; AAC26046.1; -; mRNA.
DR EMBL; BC077257; AAH77257.1; -; mRNA.
DR RefSeq; NP_001083811.1; NM_001090342.1.
DR AlphaFoldDB; O93377; -.
DR SMR; O93377; -.
DR BioGRID; 100456; 2.
DR IntAct; O93377; 1.
DR DNASU; 399131; -.
DR GeneID; 399131; -.
DR KEGG; xla:399131; -.
DR CTD; 399131; -.
DR Xenbase; XB-GENE-482006; rbbp4.L.
DR OrthoDB; 831322at2759; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR Bgee; 399131; Expressed in ovary and 19 other tissues.
DR GO; GO:0033186; C:CAF-1 complex; ISS:UniProtKB.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0031497; P:chromatin assembly; ISS:UniProtKB.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR022052; Histone-bd_RBBP4_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12265; CAF1C_H4-bd; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cell cycle; Chromatin regulator; Chromosome; DNA replication;
KW Nucleus; Reference proteome; Repeat; Repressor; Telomere; Transcription;
KW Transcription regulation; WD repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..425
FT /note="Histone-binding protein RBBP4-A"
FT /id="PRO_0000051190"
FT REPEAT 122..162
FT /note="WD 1"
FT REPEAT 175..215
FT /note="WD 2"
FT REPEAT 225..265
FT /note="WD 3"
FT REPEAT 271..311
FT /note="WD 4"
FT REPEAT 315..355
FT /note="WD 5"
FT REPEAT 372..412
FT /note="WD 6"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250"
FT CONFLICT 122..124
FT /note="THD -> NHE (in Ref. 2; AAH77257)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="N -> D (in Ref. 2; AAH77257)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 425 AA; 47569 MW; 2454C9A19457F5FC CRC64;
MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL SDVTRPDGKD
FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS EKGEFGGFGS VSGKIEIEIK
ITHDGEVNRA RYMPQNPCII ATKTPTSDVL VFDYTKHPSK PDPSGECNPN LRLRGHQKEG
YGLSWNPNLS GNLLSASDDH TICLWDISAV PKEGKVVDAK TIFTGHTAVV EDVSWHLLHE
SLFGSVADDQ KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL
WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI GEEQSPEDAE
DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ VWQMAENIYN DEDTEGGVDP
EGQGS
