RBPJL_HUMAN
ID RBPJL_HUMAN Reviewed; 517 AA.
AC Q9UBG7; O95723; Q5QPU9; Q5QPV0; Q9ULV9;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Recombining binding protein suppressor of hairless-like protein;
DE AltName: Full=Transcription factor RBP-L;
GN Name=RBPJL; Synonyms=RBPL, RBPSUHL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Saito T., Miyajima N.;
RT "Human mRNA for transcription factor RBP-L.";
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Isaka S., Koyama K., Nakamura Y., Okamura S., Azuma C., Kimura T.;
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative transcription factor, which cooperates with EBNA2 to
CC activate transcription. {ECO:0000250}.
CC -!- SUBUNIT: Interacts weakly with EBNA2. Does not interact with any Notch
CC proteins (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q9UBG7; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12346485, EBI-16439278;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UBG7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UBG7-2; Sequence=VSP_039150;
CC -!- SIMILARITY: Belongs to the Su(H) family. {ECO:0000305}.
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DR EMBL; AB027710; BAA87051.1; -; mRNA.
DR EMBL; AB024964; BAA88232.1; -; mRNA.
DR EMBL; AB026048; BAA86121.1; -; mRNA.
DR EMBL; AL021578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW75864.1; -; Genomic_DNA.
DR CCDS; CCDS13349.1; -. [Q9UBG7-1]
DR CCDS; CCDS63283.1; -. [Q9UBG7-2]
DR RefSeq; NP_001268377.1; NM_001281448.1.
DR RefSeq; NP_001268378.1; NM_001281449.1. [Q9UBG7-2]
DR RefSeq; NP_055091.2; NM_014276.3. [Q9UBG7-1]
DR AlphaFoldDB; Q9UBG7; -.
DR SMR; Q9UBG7; -.
DR BioGRID; 116448; 121.
DR DIP; DIP-60277N; -.
DR IntAct; Q9UBG7; 2.
DR STRING; 9606.ENSP00000341243; -.
DR GlyGen; Q9UBG7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9UBG7; -.
DR PhosphoSitePlus; Q9UBG7; -.
DR BioMuta; RBPJL; -.
DR DMDM; 296452986; -.
DR jPOST; Q9UBG7; -.
DR MassIVE; Q9UBG7; -.
DR MaxQB; Q9UBG7; -.
DR PaxDb; Q9UBG7; -.
DR PeptideAtlas; Q9UBG7; -.
DR PRIDE; Q9UBG7; -.
DR ProteomicsDB; 83966; -. [Q9UBG7-1]
DR ProteomicsDB; 83967; -. [Q9UBG7-2]
DR Antibodypedia; 3481; 167 antibodies from 26 providers.
DR DNASU; 11317; -.
DR Ensembl; ENST00000343694.8; ENSP00000341243.3; ENSG00000124232.11. [Q9UBG7-1]
DR Ensembl; ENST00000372743.5; ENSP00000361828.1; ENSG00000124232.11. [Q9UBG7-2]
DR GeneID; 11317; -.
DR KEGG; hsa:11317; -.
DR MANE-Select; ENST00000343694.8; ENSP00000341243.3; NM_014276.4; NP_055091.2.
DR UCSC; uc002xns.5; human. [Q9UBG7-1]
DR CTD; 11317; -.
DR DisGeNET; 11317; -.
DR GeneCards; RBPJL; -.
DR HGNC; HGNC:13761; RBPJL.
DR HPA; ENSG00000124232; Tissue enriched (pancreas).
DR MIM; 616104; gene.
DR neXtProt; NX_Q9UBG7; -.
DR OpenTargets; ENSG00000124232; -.
DR PharmGKB; PA162400876; -.
DR VEuPathDB; HostDB:ENSG00000124232; -.
DR eggNOG; KOG3743; Eukaryota.
DR GeneTree; ENSGT00390000005197; -.
DR HOGENOM; CLU_022207_0_0_1; -.
DR InParanoid; Q9UBG7; -.
DR OMA; LACAREP; -.
DR OrthoDB; 444988at2759; -.
DR PhylomeDB; Q9UBG7; -.
DR TreeFam; TF314117; -.
DR PathwayCommons; Q9UBG7; -.
DR SignaLink; Q9UBG7; -.
DR BioGRID-ORCS; 11317; 13 hits in 1070 CRISPR screens.
DR ChiTaRS; RBPJL; human.
DR GenomeRNAi; 11317; -.
DR Pharos; Q9UBG7; Tbio.
DR PRO; PR:Q9UBG7; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9UBG7; protein.
DR Bgee; ENSG00000124232; Expressed in body of pancreas and 97 other tissues.
DR ExpressionAtlas; Q9UBG7; baseline and differential.
DR Genevisible; Q9UBG7; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR CDD; cd01176; IPT_RBP-Jkappa; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 2.60.40.1450; -; 1.
DR InterPro; IPR015350; Beta-trefoil_DNA-bd_dom.
DR InterPro; IPR036358; BTD_sf.
DR InterPro; IPR040159; CLS_fam.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR015351; RBP-J/Cbf11/Cbf12_DNA-bd.
DR InterPro; IPR037095; RBP-J/Cbf11_DNA-bd_sf.
DR InterPro; IPR038007; RBP-Jkappa_IPT.
DR PANTHER; PTHR10665; PTHR10665; 1.
DR Pfam; PF09270; BTD; 1.
DR Pfam; PF09271; LAG1-DNAbind; 1.
DR Pfam; PF20144; TIG_SUH; 1.
DR SMART; SM01268; BTD; 1.
DR SMART; SM01267; LAG1_DNAbind; 1.
DR SUPFAM; SSF110217; SSF110217; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..517
FT /note="Recombining binding protein suppressor of hairless-
FT like protein"
FT /id="PRO_0000208570"
FT DOMAIN 387..512
FT /note="IPT/TIG"
FT REGION 26..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..88
FT /note="DNA-binding"
FT /evidence="ECO:0000250|UniProtKB:Q06330"
FT REGION 193..198
FT /note="DNA-binding"
FT /evidence="ECO:0000250|UniProtKB:Q06330"
FT REGION 220..225
FT /note="DNA-binding"
FT /evidence="ECO:0000250|UniProtKB:Q06330"
FT VAR_SEQ 427
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1, ECO:0000303|Ref.2"
FT /id="VSP_039150"
FT CONFLICT 428..431
FT /note="SPRS -> YGVEPAV (in Ref. 2; BAA86121/BAA88232)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 517 AA; 56751 MW; 1DB1505A800F7788 CRC64;
MDPAGAADPS VPPNPLTHLS LQDRSEMQLQ SEADRRSLPG TWTRSSPEHT TILRGGVRRC
LQQQCEQTVR ILHAKVAQKS YGNEKRFFCP PPCVYLSGPG WRVKPGQDQA HQAGETGPTV
CGYMGLDSAS GSATETQKLN FEQQPDSREF GCAKTLYISD ADKRKHFRLV LRLVLRGGRE
LGTFHSRLIK VISKPSQKKQ SLKNTDLCIS SGSKVSLFNR LRSQTVSTRY LSVEDGAFVA
SARQWAAFTL HLADGHSAQG DFPPREGYVR YGSLVQLVCT VTGITLPPMI IRKVAKQCAL
LDVDEPISQL HKCAFQFPGS PPGGGGTYLC LATEKVVQFQ ASPCPKEANR ALLNDSSCWT
IIGTESVEFS FSTSLACTLE PVTPVPLIST LELSGGGDVA TLELHGENFH AGLKVWFGDV
EAETMYRSPR SLVCVVPDVA AFCSDWRWLR APITIPMSLV RADGLFYPSA FSFTYTPEYS
VRPGHPGVPE PATDADALLE SIHQEFTRTN FHLFIQT
