RBPJL_MOUSE
ID RBPJL_MOUSE Reviewed; 515 AA.
AC O08674;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Recombining binding protein suppressor of hairless-like protein;
DE AltName: Full=Transcription factor RBP-L;
GN Name=Rbpjl; Synonyms=Rbpl, Rbpsuhl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP INTERACTION WITH EBNA2.
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=9111338; DOI=10.1128/mcb.17.5.2679;
RA Minoguchi S., Taniguchi Y., Kato H., Okazaki T., Strobl L.J.,
RA Zimber-Strobl U., Bornkamm G.W., Honjo T.;
RT "RBP-L, a transcription factor related to RBP-Jkappa.";
RL Mol. Cell. Biol. 17:2679-2687(1997).
CC -!- FUNCTION: Putative transcription factor, which cooperates with EBNA2 to
CC activate transcription.
CC -!- SUBUNIT: Interacts weakly with EBNA2. Does not interact with any Notch
CC proteins. {ECO:0000269|PubMed:9111338}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9111338}.
CC -!- TISSUE SPECIFICITY: Highly expressed in lung. Also detected in spleen,
CC and brain. {ECO:0000269|PubMed:9111338}.
CC -!- SIMILARITY: Belongs to the Su(H) family. {ECO:0000305}.
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DR EMBL; Y10926; CAA71856.1; -; mRNA.
DR CCDS; CCDS17035.1; -.
DR RefSeq; NP_033062.1; NM_009036.1.
DR AlphaFoldDB; O08674; -.
DR SMR; O08674; -.
DR BioGRID; 202836; 13.
DR CORUM; O08674; -.
DR IntAct; O08674; 1.
DR STRING; 10090.ENSMUSP00000017151; -.
DR PhosphoSitePlus; O08674; -.
DR EPD; O08674; -.
DR PaxDb; O08674; -.
DR PeptideAtlas; O08674; -.
DR PRIDE; O08674; -.
DR ProteomicsDB; 255050; -.
DR Antibodypedia; 3481; 167 antibodies from 26 providers.
DR DNASU; 19668; -.
DR Ensembl; ENSMUST00000017151; ENSMUSP00000017151; ENSMUSG00000017007.
DR GeneID; 19668; -.
DR KEGG; mmu:19668; -.
DR UCSC; uc008nup.1; mouse.
DR CTD; 11317; -.
DR MGI; MGI:1196616; Rbpjl.
DR VEuPathDB; HostDB:ENSMUSG00000017007; -.
DR eggNOG; KOG3743; Eukaryota.
DR GeneTree; ENSGT00390000005197; -.
DR HOGENOM; CLU_022207_2_0_1; -.
DR InParanoid; O08674; -.
DR OMA; LACAREP; -.
DR OrthoDB; 444988at2759; -.
DR PhylomeDB; O08674; -.
DR TreeFam; TF314117; -.
DR BioGRID-ORCS; 19668; 3 hits in 72 CRISPR screens.
DR PRO; PR:O08674; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; O08674; protein.
DR Bgee; ENSMUSG00000017007; Expressed in metanephros induced blastemal cells and 36 other tissues.
DR ExpressionAtlas; O08674; baseline and differential.
DR Genevisible; O08674; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI.
DR CDD; cd01176; IPT_RBP-Jkappa; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 2.60.40.1450; -; 1.
DR InterPro; IPR015350; Beta-trefoil_DNA-bd_dom.
DR InterPro; IPR036358; BTD_sf.
DR InterPro; IPR040159; CLS_fam.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR015351; RBP-J/Cbf11/Cbf12_DNA-bd.
DR InterPro; IPR037095; RBP-J/Cbf11_DNA-bd_sf.
DR InterPro; IPR038007; RBP-Jkappa_IPT.
DR PANTHER; PTHR10665; PTHR10665; 1.
DR Pfam; PF09270; BTD; 1.
DR Pfam; PF09271; LAG1-DNAbind; 1.
DR Pfam; PF20144; TIG_SUH; 1.
DR SMART; SM01268; BTD; 1.
DR SMART; SM01267; LAG1_DNAbind; 1.
DR SUPFAM; SSF110217; SSF110217; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..515
FT /note="Recombining binding protein suppressor of hairless-
FT like protein"
FT /id="PRO_0000208571"
FT DOMAIN 384..474
FT /note="IPT/TIG"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..86
FT /note="DNA-binding"
FT /evidence="ECO:0000250|UniProtKB:Q06330"
FT REGION 191..196
FT /note="DNA-binding"
FT /evidence="ECO:0000250|UniProtKB:Q06330"
FT REGION 218..223
FT /note="DNA-binding"
FT /evidence="ECO:0000250|UniProtKB:Q06330"
FT COMPBIAS 23..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 56780 MW; 7DEBBEA37EAAEAF4 CRC64;
MDPRETTDPS LPPGPLTHLS LPDSSEVRLQ SDGPSLLGSW TRSPPEHAII LREGVRTCLQ
QRCEQTVWIL HAKVAQKSYG NEKRFFCPPP CVYLAGPGWR VKPMQDQALQ SAETGPTVCG
YMGLDGASGS APETQKLNFE EQPDSREFGC AKTLYISDAD KRKHFRLVLR LVLRGGQELG
TFHSRLIKVI SKPSQKKQSL KNTDLCISSG SKVSLFNRLR SQTVSTRYLS VEDGAFVASA
RQWAAFTLHL ADGHCSQGDF PPQEGYIRYG SLVQLVCTVT GITLPPMIIR KVAKQCALLD
VDEPISQLHK CAFQFPSDTP GGAGTYLCLA TEKVVRFQAS LCPKEANRAL LNDSSCWTII
GTESVEFTFS TSLACTREPV TPVPLISTLE LSGGGDVATL ELHGENFHAG LKVWFGDVEA
ETMYRSPRSL VCVVPDVAAF GSDWRWLRTP ITVPVSLLRA DALFYPSPFS FTYTPEYSAL
PRLPNAQEPA PDADTLLESI HHEFTRTNFH LFCPT
