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RBPS2_MOUSE
ID   RBPS2_MOUSE             Reviewed;         206 AA.
AC   Q8VC52;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=RNA-binding protein with multiple splicing 2;
GN   Name=Rbpms2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=NOD; TISSUE=Lung, and Spleen;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP   METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA   Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of mouse liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
CC   -!- FUNCTION: RNA-binding protein involved in the regulation of smooth
CC       muscle cell differentiation and proliferation in the gastrointestinal
CC       system (By similarity). Binds NOG mRNA, the major inhibitor of the bone
CC       morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA
CC       levels, thereby contributing to the negative regulation of BMP
CC       signaling pathway and promoting reversible dedifferentiation and
CC       proliferation of smooth muscle cells (By similarity).
CC       {ECO:0000250|UniProtKB:Q6ZRY4, ECO:0000250|UniProtKB:Q9W6I1}.
CC   -!- SUBUNIT: Homodimer. Interacts with EEF2.
CC       {ECO:0000250|UniProtKB:Q6ZRY4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6ZRY4}.
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DR   EMBL; AK144659; BAE25995.1; -; mRNA.
DR   EMBL; AK156633; BAE33785.1; -; mRNA.
DR   EMBL; BC021788; AAH21788.1; -; mRNA.
DR   CCDS; CCDS23296.1; -.
DR   RefSeq; NP_082306.2; NM_028030.3.
DR   RefSeq; XP_006511518.1; XM_006511455.2.
DR   RefSeq; XP_006511519.1; XM_006511456.3.
DR   RefSeq; XP_006511520.1; XM_006511457.2.
DR   RefSeq; XP_006511521.1; XM_006511458.3.
DR   AlphaFoldDB; Q8VC52; -.
DR   BMRB; Q8VC52; -.
DR   SMR; Q8VC52; -.
DR   STRING; 10090.ENSMUSP00000057600; -.
DR   iPTMnet; Q8VC52; -.
DR   PhosphoSitePlus; Q8VC52; -.
DR   jPOST; Q8VC52; -.
DR   MaxQB; Q8VC52; -.
DR   PaxDb; Q8VC52; -.
DR   PeptideAtlas; Q8VC52; -.
DR   PRIDE; Q8VC52; -.
DR   ProteomicsDB; 254900; -.
DR   Antibodypedia; 25848; 91 antibodies from 17 providers.
DR   DNASU; 71973; -.
DR   Ensembl; ENSMUST00000055844; ENSMUSP00000057600; ENSMUSG00000032387.
DR   GeneID; 71973; -.
DR   KEGG; mmu:71973; -.
DR   UCSC; uc009qdt.1; mouse.
DR   CTD; 348093; -.
DR   MGI; MGI:1919223; Rbpms2.
DR   VEuPathDB; HostDB:ENSMUSG00000032387; -.
DR   eggNOG; KOG1457; Eukaryota.
DR   GeneTree; ENSGT00940000158086; -.
DR   InParanoid; Q8VC52; -.
DR   OMA; MRWFPSS; -.
DR   OrthoDB; 1368991at2759; -.
DR   PhylomeDB; Q8VC52; -.
DR   TreeFam; TF351070; -.
DR   BioGRID-ORCS; 71973; 3 hits in 73 CRISPR screens.
DR   ChiTaRS; Rbpms2; mouse.
DR   PRO; PR:Q8VC52; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q8VC52; protein.
DR   Bgee; ENSMUSG00000032387; Expressed in animal zygote and 217 other tissues.
DR   ExpressionAtlas; Q8VC52; baseline and differential.
DR   Genevisible; Q8VC52; MM.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0003729; F:mRNA binding; ISO:MGI.
DR   GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR   GO; GO:0048557; P:embryonic digestive tract morphogenesis; ISS:UniProtKB.
DR   GO; GO:0030514; P:negative regulation of BMP signaling pathway; ISS:UniProtKB.
DR   GO; GO:0051151; P:negative regulation of smooth muscle cell differentiation; ISS:UniProtKB.
DR   GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB.
DR   CDD; cd12683; RRM_RBPMS2; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034787; RBPMS2_RRM.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Developmental protein; Reference proteome;
KW   RNA-binding.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0007744|PubMed:17242355"
FT   CHAIN           2..206
FT                   /note="RNA-binding protein with multiple splicing 2"
FT                   /id="PRO_0000274910"
FT   DOMAIN          25..102
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          35..45
FT                   /note="Important for homodimerization"
FT                   /evidence="ECO:0000250|UniProtKB:Q6ZRY4"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0007744|PubMed:17242355"
SQ   SEQUENCE   206 AA;  22463 MW;  E90703F99B97ACD2 CRC64;
     MSNLKPDVEH CTGAGTGSPL EEEVRTLFVS GLPVDIKPRE LYLLFRPFKG YEGSLIKLTS
     RQPVGFVIFD SRAGAEAAKN ALNGIRFDPE NPQTLRLEFA KANTKMAKSK LIATPNPTSV
     HPALGAHLIA RDPYDLMGTA LIPASPEAWA PYPLYTTELT PAISHTTFTY PAATAAAAAA
     ATLHAQVRWY PSSDTTQQGW KYRQFC
 
 
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